Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

Jin, Qiuchen; Teng, Fangjun; Cheng, Zhiyong

doi:10.1371/journal.pone.0258138

Cited by 18 publications

(20 citation statements)

References 59 publications

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“…In the present study, it was found that individuals who had the polymorphism in the IL-1B +3954 had an almost twice higher risk of developing peri-implantitis (OR 1.986). This result is in agreement with a meta-analysis performed by Jin et al where the association between IL-1A −889, ILB +3954, IL-1B -511, composite genotype of IL-1A −889 and ILB +3954, and TNF-α −308 and risk of peri-implant disease (PID) was evaluated [29]. The PID included implant failure/loss, marginal bone loss and peri-implantitis.…”

Section: Discussionsupporting

confidence: 91%

“…Some of them do not refer to confounding variables such as periodontal condition, ethnicity and smoking habits. Furthermore, many studies, including published systematic reviews, assess the relationship of these polymorphisms with the peri-implant disease, pooling in the same group patients with bone loss, implant loss, and peri-implantitis [27][28][29]. However, peri-implant tissue health can exist around implants with variable levels of bone support [6].…”

Section: Introductionmentioning

confidence: 99%

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Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

et al. 2022

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Recent studies report that individuals with polymorphisms in the genes that encode for interleukin (IL)-1α and IL-1β (IL-1A and IL1B, respectively) and for IL-1 receptor antagonist (IL-1RN) may be more susceptible in developing peri-implantitis. Therefore, the current systematic review evaluates what is reported about the role of genetics, more specifically of single nucleotide polymorphisms (SNP) on IL-1 and variable number of tandem repeats (VNTR) on IL-1RN, in the development of peri-implantitis. This systematic review was carried out by screening PubMed, B-on, Cochrane and Scopus databases, for articles English, Spanish, and Portuguese, with no limit regarding the publication year. Eight articles were selected for systematic review and four for meta-analytic syntheses. Our results show that although there is a lack of consensus in the literature, there seems to be an association between IL-1A, IL-1B, and IL-1RN polymorphisms with peri-implantitis. The results of the meta-analysis showed that patients who have the polymorphic allele at position +3954 of the IL-1B gene have on average almost twice the risk of developing peri-implantitis (odds ratio = 1.986, 95% confidence interval).

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

et al. 2022

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“…The close association of the four genetic variants IL-1a, IL-1b, TNF-a and IL-1RN with the risk of peri-implantitis development or implant loss has been demonstrated in a large number of worldwide association studies and was also confirmed in meta-analyses [ 72 , 73 ]. It was concluded that functional polymorphisms of IL-a < (C-889 T), IL-b (C + 3954 T and C-511 T) and composite genotype of IL-1 are valuable as predictive markers for peri-implant disease.…”

Section: Discussionmentioning

confidence: 83%

Diagnostic tests for titanium hypersensitivity in implant dentistry: a systematic review of the literature

et al. 2022

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Purpose There are rising concerns about titanium hypersensitivity reaction regarding dental endosseous implants. This review aims to summarize and compare the validity and reliability of the available dermatological and laboratory diagnostic tests regarding titanium hypersensitivity. The following PICO design was used: In Patients with titanium dental implants (P) does epicutaneous testing (ECT) (I), compared to lymphocyte transformation test (LTT) or Memory Lymphocyte Immunostimulation Assay (MELISA) (C) detect hypersensitivity reactions (O)? A literature search was performed including all studies dealing with this topic. Studies regarding orthopedic implants were excluded. Methods Three databases (MEDLINE PubMed, Cochrane Library, SciELO) were screened for suitable studies and an additional manual search was also performed. Literature regarding hypersensitivity reactions in orthopedic implants, hypersensitivity reactions regarding implants not related to dental or maxillofacial surgery, animal studies and in vitro studies were excluded. A quality assessment of all selected full-text articles was performed. Randomized, controlled trials were evaluated with the Cochrane Risk of Bias Tool I. Cohort studies were assessed according to the New Castle–Ottawa Scale and case series according to Moga et al. (Development of a quality appraisal tool for case series studies using a modified Delphi technique. 2012). Results 10 studies were included in the quantitative synthesis and available for the endpoint diagnostics of intolerance reactions to titanium dental implants: 2 clinical studies, 7 cohort studies and 1 case series. The potential for bias (internal validity) for these studies was overall rated as high. Conclusions The study of the available literature regarding ECT and MELISA or LTT in patients with suspected titanium hypersensitivity showed inconsistent results in terms of reliability and validity and thus, those tests should be regarded cautiously. There is strong evidence that titanium hypersensitivity in dental implants is associated with innate immunity: unspecific pro-inflammatory responses due to particle induced hyperreactivity of macrophages or toxicological responses especially towards nanoparticles rather than activation of the adaptive immune system. Therefore, tests detecting allergies do not seem expedient and inflammatory clinical signs should be regarded as leading parameters. Graphical Abstract

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“…A recent meta-analysis found that carriers of positive genotype of IL-1A-889 and IL-1B+3954 had 1.95-fold risk of peri-implant disease (which included implant failure/loss, marginal bone loss and peri-implantitis). The authors concluded that the positive genotype of IL-1 can be used as predictive marker for peri-implant disease ( Jin, Teng & Cheng, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Association between IL-1A and IL-1B gene polymorphisms with peri-implantitis in a Portuguese population—a pilot study

Cardoso

Ribeiro

Palos

et al. 2022

PeerJ

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Background Scientific evidence indicates that biological complications in dental implants tend to be concentrated in a subset of individuals, which seems to imply that the host response may play a determining role in implant success. Over the last few decades, several polymorphisms have been studied. Polymorphisms in the interleukin (IL) 1 gene cluster have been associated with periodontitis. There are some similar features in the sequence of immunopathological events in peri-implant and periodontal infections. We aimed to investigate if individuals carrying the genetic single nucleotide polymorphism (SNP) in the IL-1A (rs1800587) and IL-1B (rs1143634) genes are more susceptible to develop peri-implantitis. Methods A cross-sectional analytic pilot study was conducted in 20 Caucasian Portuguese subjects divided into two groups: 10 subjects with peri-implantitis and 10 subjects with peri-implant health (control group). Samples containing cells from the buccal mucosa were stored at −20 °C and later submitted to the DNA extraction process. Genetic analysis was performed using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Data were analyzed by using descriptive and inferential statistical methodologies. Results For the IL-1A (−889) gene polymorphism, it was observed that the mutated allele was present in a higher percentage in the peri-implantitis group compared to the control group (30% vs 15% respectively, Fisher’s exact test, p = 0.45). For the IL-1B (+3954) gene polymorphism, it was also observed that the altered allele was present in a higher percentage in the disease group compared to the control group (35% vs 10% respectively, Fisher’s exact test, p = 0.13). The positive genotype (at least one allele with nucleotide sequence changed in both genes) was detected in six patients, five belonging to the disease group and one to the health group. Conclusions Regarding IL-1 gene polymorphisms, there was no statistically significant difference between the health and disease group, however a trend should be highlighted, showing a potential link between the IL-1 genotype and peri-implantitis. More studies are needed to clarify the role of genetic polymorphisms in the development of peri-implantitis.

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Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

Cited by 18 publications

References 59 publications

Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

Diagnostic tests for titanium hypersensitivity in implant dentistry: a systematic review of the literature

Association between IL-1A and IL-1B gene polymorphisms with peri-implantitis in a Portuguese population—a pilot study

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