Association of TNF-α, TNFRSF1A and TNFRSF1B Gene Polymorphisms with the Risk of Sporadic Breast Cancer in Northeast Chinese Han Women

Xu, Fei; Zhou, Guiqin; Han, Shaoli; Yuan, Weiguang; Chen, Shuang; Fu, Zhenkun; Li, Dalin; Zhang, Hua; Li, Dianjun; Pang, Da

doi:10.1371/journal.pone.0101138

Cited by 35 publications

(37 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Both SNPs have previously been implicated in numerous complex human diseases including sporadic breast cancer (Xu et al 2014), inflammatory demyelinating disease (Park et al 2013) and ankylosing spondylitis (Davidson et al 2011). We based our SNP selection on the following criteria: (1) SNPs should have been validated by both the HapMap project and the 1000 genomes project in Caucasian populations; (2) SNPs should have a high minor allele frequency (MAF) (i.e.…”

Section: Snp Selectionmentioning

confidence: 99%

TNF receptors 1 and 2 exert distinct region‐specific effects on striatal and hippocampal grey matter volumes (VBM) in healthy adults

Stacey

Redlich²,

Büschel³

et al. 2016

Genes Brain and Behavior

View full text Add to dashboard Cite

Tumour necrosis factor alpha (TNFα) has been implicated in the pathophysiology of neurodegenerative and neuropsychiatric disease, with research highlighting a role for TNFα in hippocampal and striatal regulation. TNFα signals are primarily transduced by TNF receptors 1 and 2 (TNFR1 and TNFR2), encoded by TNFRSF1A and TNFRSF1B, which exert opposing effects on cell survival (TNFR1, neurodegenerative; TNFR2, neuroprotective). We therefore sought to explore the respective roles of TNFR1 and TNFR2 in the regulation of hippocampal and striatal morphology in an imaging genetics study. Voxel-based morphometry was used to analyse the associations between TNFRSF1A (rs4149576 and rs4149577) and TNFRSF1B (rs1061624) genotypes and grey matter structure. The final samples comprised a total of 505 subjects (mean age = 33.29, SD = 11.55 years; 285 females and 220 males) for morphometric analyses of rs1061624 and rs4149576, and 493 subjects for rs4149577 (mean age = 33.20, SD = 11.56 years; 281 females and 212 males). Analyses of TNFRSF1A single nucleotide polymorphisms (SNPs) rs4149576 and rs4149577 showed highly significant genotypic associations with striatal volume but not the hippocampus. Specifically, for rs4149576, G homozygotes were associated with reduced caudate nucleus volumes relative to A homozygotes and heterozygotes, whereas for rs4149577, reduced caudate volumes were observed in C homozygotes relative to T homozygotes and heterozygotes. Analysis of the TNFRSF1B SNP rs1061624 yielded a significant association with hippocampal but not with striatal volume, whereby G homozygotes were associated with increased volumes relative to A homozygotes and heterozygotes. Our findings indicate a role for TNFR1 in regulating striatal but not hippocampal morphology, as well as a complementary role for TNFR2 in hippocampal but not in striatal morphology.

show abstract

Section: Snp Selectionmentioning

confidence: 99%

TNF receptors 1 and 2 exert distinct region‐specific effects on striatal and hippocampal grey matter volumes (VBM) in healthy adults

Stacey

Redlich²,

Büschel³

et al. 2016

Genes Brain and Behavior

View full text Add to dashboard Cite

show abstract

“…Five of these loci were previously reported to have variable association with the risk of single primary colorectal cancer; rs1061624 of TNFRSF1B, rs1059234 of P21, and rs9344 of CCND1 were found to reduce the risk of colorectal cancer and exert protective effects, while rs28362491 of NFKB1 and rs3212986 of ERCC1 increased the risk of colorectal cancer. Among the other 30 loci, five (rs7566, rs887574, rs13035, rs1799757, and rs5343) are reported for the first time in this study, while 25 were associated with malignant tumor development and the response to chemoradiotherapy (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33), inflammatory bowel disease (34), autoimmune diseases (35,36), vitiligo (37), insulin resistance (38), coronary heart disease, stroke, and other types of cardiovascular and cerebrovascular disease (39,40).…”

Section: Discussionmentioning

confidence: 73%

Polymorphisms of cancer-related genes and risk of multipleprimary malignancies involving colorectal cancer

Cao¹,

Yu²,

Wu³

et al. 2017

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim: This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of cancer-related genes and the risk of multiple primary malignancies involving colorectal cancer. Materials and methods:We collected tissue samples from 22 multiple primary cancer patients with primary colorectal cancer and performed genotyping assay for 116 SNP loci from 62 genes encoding peptides functioning in various signaling pathways using the DNA MassARRAY system. The chi-square test was used to compare the differences in base frequencies between patients and a control Chinese population from HapMap through the NCBI database.Results: No significant differences in frequencies were detected for 81 SNPs (P > 0.05), while serious frequency differences were observed for 35 SNPs from 31 genes (P < 0.05), which included ERCC6 (rs2228526), ERCC1 (rs3212986), CASP8 (rs3834129, rs3769818), and others presented. Five of these SNPs were previously reported to be associated with the pathogenesis of colorectal cancer. Conclusion:The 35 SNPs from 31 genes may be associated with the risk of multiple primary malignancies involving colorectal cancer.

show abstract

“…[9–15] Characteristics of the included studies are shown in Table 1. All studies used healthy volunteers or blood donors as control subjects.…”

Section: Resultsmentioning

confidence: 99%

Tumor necrosis factor alpha-238G/A polymorphism and risk of breast cancer

Zhang

Zhao²,

Yuan³

et al. 2017

Medicine

View full text Add to dashboard Cite

Background:The association between the tumor necrosis factor-alpha gene (TNF-a) -238G/A polymorphism and the breast cancer has been analyzed in several studies, but the results have been inconclusive. We then performed a meta-analysis to get a precise estimation of the association.Methods:Eight case–control studies with a total of 37,257 cases and 39,564 controls were identified by searching the ISI Web of Knowledge database and the PubMed database up to August 2014.Results:Overall, no association was found between TNF-alpha-238G/A polymorphism and breast cancer in any of genetic model (additive model OR = 1.06, 95%CI: 0.94–1.21, Pheterogeneity = .02; homozygous model OR = 1.04, 95%CI: 0.83–1.30, Pheterogeneity = .98; dominant model OR = 1.06, 95%CI: 0.92–1.21, Pheterogeneity = .01; recessive model OR = 1.04, 95%CI: 0.83–1.30, Pheterogeneity = .98). Furthermore, no significant association was identified when stratified by ethnicity (Caucasian, Asian).Conclusion:This meta-analysis indicated that the TNF-alpha-238G/A polymorphism is not associated with breast cancer risk in the overall population.

show abstract

Association of TNF-α, TNFRSF1A and TNFRSF1B Gene Polymorphisms with the Risk of Sporadic Breast Cancer in Northeast Chinese Han Women

Cited by 35 publications

References 40 publications

TNF receptors 1 and 2 exert distinct region‐specific effects on striatal and hippocampal grey matter volumes (VBM) in healthy adults

TNF receptors 1 and 2 exert distinct region‐specific effects on striatal and hippocampal grey matter volumes (VBM) in healthy adults

Polymorphisms of cancer-related genes and risk of multipleprimary malignancies involving colorectal cancer

Tumor necrosis factor alpha-238G/A polymorphism and risk of breast cancer

Contact Info

Product

Resources

About