Association of TNFSF15 With Crohn's Disease in Koreans

Yang, Suk‐Kyun; Lim, Jin Hee; Chang, Hyo Won; Lee, Inchul; Li, Yuqing; Li, Jianjun; Song, Kyuyoung

doi:10.1111/j.1572-0241.2007.01752.x

Cited by 81 publications

(72 citation statements)

References 25 publications

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“…[23][24][25][26] TNFSF15 (tumor necrosis factor ligand superfamily, member 15) was the first CD-susceptibility gene identified through a genome-wide association screening of 72 738 single-nucleotide polymorphisms (SNPs) in Japanese population. 10 The association was well replicated by several studies, including our previous study in a Korean cohort, 27 an independent Japanese cohort 28 and a US cohort, 29 and metaanalyses of genome-wide association studies in European populations, 22 although the association was less significant in Europeans than in Japanese or Korean individuals. 29,30 However, reports of an association of TNFSF15 with UC in Caucasians have been inconsistent.…”

Section: Introductionmentioning

confidence: 59%

“…10,16,[27][28][29][30] In fact, the association of TNFSF15 with CD is much stronger in Asians than in Caucasians. 29,30 The association of IL23R with CD is consistently observed in Caucasians, but among Asians, this association has been demonstrated only in Koreans.…”

Section: Discussionmentioning

confidence: 99%

“…Part of this cohort has been studied previously. 27,31 All patients with UC or CD were diagnosed at the IBD Clinic of Asan Medical Center, Seoul, Korea on the basis of conventional, clinical, radiological, endoscopic and histopathological criteria. 32,33 Patients with indeterminate colitis were excluded from the study.…”

Section: Study Subjectsmentioning

confidence: 99%

“…[24][25][26] In a previous report on Korean patients with CD, we replicated findings from studies on Caucasian populations, establishing interleukin 23 receptor (IL23R) and TNFSF15 as CD-susceptibility genes. 27,31 Because some CD candidate genes involved in the Th17 pathway were shown to be shared with UC in Caucasians, in this study we sought to test the association between IL23R or TNFSF15 polymorphisms and UC in Koreans. We found that IL23R, which was reported to be associated with UC as well as CD in Caucasians, was not associated with UC in Koreans.…”

Section: Introductionmentioning

confidence: 99%

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No association between TNFSF15 and IL23R with ulcerative colitis in Koreans

et al. 2011

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Recent genome-wide association studies have shown that some Crohn's disease (CD)-associated loci also contribute to ulcerative colitis (UC) susceptibility. To understand the genetic relationship between the two forms of inflammatory bowel disease, we investigated the well-established CD-susceptibility genes TNFSF15 (tumor necrosis factor ligand superfamily, member 15) and IL23R in Korean patients with UC. Eight TNFSF15 and five IL23R single-nucleotide polymorphisms were genotyped in 654 patients with UC and in 601 healthy controls. There was no association between TNFSF15 or IL23R variants and UC in Korean individuals, in contrast to previous reports of a shared association of the IL23R gene with both CD and UC in Caucasian individuals. Our data suggest that neither TNFSF15 nor IL23R variants contribute to UC susceptibility in Koreans.

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Section: Introductionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Study Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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No association between TNFSF15 and IL23R with ulcerative colitis in Koreans

et al. 2011

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“…Part of this cohort was studied previously. [34][35][36] All patients with CD or UC were diagnosed at the IBD Clinic of Asan Medical Center, Seoul, Korea on the basis of clinical, radiologic, endoscopic and histopathologic criteria. [37][38][39] Patients with indeterminate colitis were excluded from the study.…”

Section: Study Populationmentioning

confidence: 99%

Association of CARD8 with inflammatory bowel disease in Koreans

et al. 2011

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Caspase recruitment domain (CARD)-containing protein 8 (CARD8) is a potential candidate risk gene for inflammatory bowel disease (IBD) because of its role as a component of the NALP3 inflammasome and as an inhibitor of nuclear factor-kappa B. Previous studies examining the association of a CARD8 single-nucleotide polymorphism (SNP) (rs2043211, p.Cys10X) with IBD yielded mixed results in Caucasians that may result from interaction with NALP3 or NOD2 (nucleotide-binding oligomerization domain 2) variants. To understand the genetic association between CARD8/NALP3 and IBD in Koreans, we investigated seven CARD8, four NALP3 and four NOD2 SNPs in 650 Crohn's disease (CD), 660 ulcerative colitis (UC) patients and 688 controls from the Korean population. rs2043211 of CARD8 showed significant association with UC (P¼0.011; odds ratio¼1.50, 95% confidence intervals¼1.12-2.00, P¼0.006 under recessive model). In contrast, an SNP in intron 1, rs1972619, was associated with CD only (P¼0.033). None of the NALP3 or NOD2 SNPs was significantly associated with CD or UC in the Korean populations. The stop allele of rs2043211 was associated with higher serum interleukin-1b levels only in female patients with UC (P¼0.027). Our data suggest that CARD8 variants might have roles in the pathogenesis of CD and UC in Koreans.

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