Association of tumor necrosis factor-α gene promoter polymorphisms (-308G/A, -238G/A) with recurrent spontaneous abortion: a meta-analysis

Zhang, Bingzhen; Liu, Tiecheng; Wang, Zhiping

doi:10.1016/j.humimm.2012.01.008

Cited by 13 publications

(12 citation statements)

References 26 publications

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“…Sensitivity analysis also demonstrated that the overall results were reliable and robust, with no single influential study. All in all, the overall analyses found no significant associations in all five genetic models, which is quite opposite to the results of two recent meta-analyses in 2012 and 2016 [49, 50], whereas consistent with the meta-analysis in 2009 [48] and two reviews about the effect of polymorphisms of TNF-α[54, 55]. …”

Section: Discussioncontrasting

confidence: 92%

“…After looking into the previous meta-analyses with great care, we noticed that some data could not be found in the original manuscripts [31, 44–46] were listed out and analyzed in the meta-analyses in 2009 [48] and 2012 [49], and some studies without sufficient data to calculate HWE [28, 31, 45, 46] were included and analyzed in the meta-analysis in 2016 [50] (Table 4). The possibility exists that the suspicious data in the meta-analysis in 2012 may be obtained from authors directly.…”

Section: Discussionmentioning

confidence: 99%

“…However, the results of these studies are inconsistent and often conflicting. Although one meta-analysis of 7 studies in 2009 [48], another one of 12 studies in 2012 [49], and the third one of 10 studies in 2016 [50] have been conducted, their conclusions were conflicting and unreliable due to the inclusion of studies deviating significantly from Hardy-Weinberg equilibrium (HWE) [39, 40], and studies without sufficient data to calculate HWE [44–47]. Meanwhile, a missing study [32] in the previous meta-analyses and a couple of new studies with different results [38, 41, 42] were found by us during the investigation.…”

Section: Introductionmentioning

confidence: 99%

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No Association between TNF-α -308G/A Polymorphism and Idiopathic Recurrent Miscarriage: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Dong

Zhou

et al. 2016

PLoS ONE

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BackgroundConflicting results were reported on the association between the TNF-α -308G/A polymorphism and idiopathic recurrent miscarriage (IRM). Though three meta-analyses have been conducted on this topic, the conclusions were contradictory, and the results may be unreliable as certain crucial conditions were neglected.MethodA complete search was conducted in PubMed, Cochrane Library, and Embase, other sources like Google Scholar, ClinicalTrial.gov and reference lists of relevant articles were also retrieved. All candidate articles were accessed and screened using specific inclusion and exclusion criteria. Statistical analyses were performed on data extracted from eligible studies using the STATA 12.0 software and the TSA 0.9 beta software.ResultsEventually, 12 case-control studies from 11 publications (with 1,807 cases and 2,012 controls) were included in this meta-analysis, and no evidence of any significant association was found in the overall analyses between the TNF-α -308G/A polymorphism and IRM risk. However, significant association was shown in Asian population (four studies from three publications) in the dominant model (AA + GA vs. GG), the allelic model (A vs. G), and the heterozygote model (GA vs. GG).ConclusionsTNF-α -308G/A polymorphism is not associated with IRM risk. Though significant association was found in Asian population, the result needs further confirmation from more studies.

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Section: Discussioncontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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No Association between TNF-α -308G/A Polymorphism and Idiopathic Recurrent Miscarriage: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Dong

Zhou

et al. 2016

PLoS ONE

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“…[15][16][17] A study showed that -238 allele is associated with higher TNF-a production with respect to the -238 G allele, 18 however, this result was not confirmed by other studies. 19,20 The GAEA substitution in position -238 in the TNF-a gene is associated with lower production of TNF-a in patients with ulcerative colitis.…”

mentioning

confidence: 84%

Tumor Necrosis Factor Alpha Gene Polymorphism and Association With Its Serum Level in Iranian Population with Rheumatoid Arthritis

2016

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Objectives: This study aims to determine whether promoter -238 G/A polymorphism in tumor necrosis factor-alpha (TNF-α) gene is associated with susceptibility to rheumatoid arthritis (RA) in Iranian population and serum level of TNF-a. Patients and methods:This case-controlled study was performed on two groups including 90 RA patients (20 males, 70 females; mean age 50.3 years; range 26 to 65 years) and 90 healthy controls (21 males, 69 females; mean age 48.6 years; range 27 to 63 years). We determined the frequency of -238 G/A TNF-a gene polymorphism by polymerase chain reaction restriction fragment length polymorphism. We measured the serum level of TNF-a using enzyme-linked immunosorbent assay method. Also, we determined the association of serum TNF-a level with the polymorphism in RA patients.

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“…Few studies found both -238 and -308 loci significantly important in correlation with diseases [41–43]. Many studies found both -308 and -238 loci nonsignificant when seeking for correlation between clinical manifestations and genetic materials [15, 44–47]. When comparing locus -308 with other loci (-238, -836), the correlation of locus -308 with other diseases such as Guillain-Barré syndrome [48], tuberculosis [49], and ANCA-associated vasculitis [50] has recently been approved.…”

Section: Introductionmentioning

confidence: 99%

The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection

Tayebi

Ashraf

2012

Hepatitis Research and Treatment

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Background and Aims. TNF-α -308 allele promoter polymorphism has been known to be a potential prognostic factor in patients with chronic HBV infection. We tried to determine how TNF-α -308 allele promoter polymorphism would affect the prognosis in patients with chronic HBV infection. Methods. We searched MEDLINE, EMBASE, and reference lists of relevant review articles related to the association between “TNF-α G-308A promoter polymorphism” with “chronic HBV infection”. We only focused on searching -308 locus in published studies. We reviewed 21 original articles about TNF-α -308 allele polymorphism and its effect on prognosis in patients with chronic HBV infection and discussed the results. Results. conflicting results were observed. The results were divided into 3 groups including neutral, negative, and positive associations between TNF-α -308 allele polymorphism and prognosis in patients with chronic HBV infection. We summarized the primary data as a table. Conclusions. Authors concluded that although there is an upward trend in evidence to claim that there is a positive relation between TNF-α G-308A promoter polymorphisms and resolution of chronic HBV infection, due to many biases and limitations observed in reviewed studies, an organized well-designed study is needed for clarifying the real association.

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Association of tumor necrosis factor-α gene promoter polymorphisms (-308G/A, -238G/A) with recurrent spontaneous abortion: a meta-analysis

Cited by 13 publications

References 26 publications

No Association between TNF-α -308G/A Polymorphism and Idiopathic Recurrent Miscarriage: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

No Association between TNF-α -308G/A Polymorphism and Idiopathic Recurrent Miscarriage: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Tumor Necrosis Factor Alpha Gene Polymorphism and Association With Its Serum Level in Iranian Population with Rheumatoid Arthritis

The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection

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