Association of two apolipoprotein A‐I gene <i>Msp</i>I polymorphisms with high density lipoprotein (HDL)‐cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early‐onset type 2 diabetes

Qing, Yan; Thomas, G. Neil; Ng, Maggie; Critchley, J. A. J. H.; Cockram, Clive S.; Chan, Juliana C.N.; Tomlinson, Brian

doi:10.1046/j.1365-2265.2003.01865.x

Cited by 16 publications

(14 citation statements)

References 39 publications

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“…The evaluation of two or three risk variants revealed a significant influence of variants of the APOA1, CETP and SCARB1 genes on HDL-C levels. This finding is in agreement with studies of APOA1 and CETP genes in other populations 8,[33][34][35][36][37] . However, for the Gly2Ser SNP of the SCARB1 gene, the few studies conducted so far associated the presence of the 2Gly allele with a decrease in HDL-C levels.…”

Section: Discussionsupporting

confidence: 83%

Influência de combinações genéticas nos níveis de HDL-c em uma população do sul do Brasil

Andrade¹,

Fiegenbaum²,

Almeida³

et al. 2010

Arq. Bras. Cardiol.

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Section: Discussionsupporting

confidence: 83%

Influência de combinações genéticas nos níveis de HDL-c em uma população do sul do Brasil

Andrade¹,

Fiegenbaum²,

Almeida³

et al. 2010

Arq. Bras. Cardiol.

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“…In addition, it has been suggested that ?83T allele was also associated with higher transcription rate of APOA1, although ?83C/T polymorphism is located in the first intron [14]. Likewise, -75A and ?83T alleles have also been associated with higher HDL levels in some populations [13,14,19,20], whereas this association was not found in others [15,16]. Moreover, ?83T allele was associated with lower triglyceride levels in Chinese population [47].…”

Section: Discussionmentioning

confidence: 89%

“…In addition, GT haplotype carriers presented decreased risk to develop obesity comparing to GC haplotype, suggesting that GT haplotype might be protective against obesity. In Chinese population, ?83T allele was associated with lower BMI in diabetic patients [20].…”

Section: Discussionmentioning

confidence: 99%

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Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

et al. 2009

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Several polymorphisms in apolipoprotein A1 (APOA1) gene have been associated with metabolic diseases. Increased transcription efficiency was observed in -75A allele carriers compared to -75G allele homozygotes. +83C allele was associated with higher body mass index and waist-to-hip ratio in type II diabetes subjects. -75G/A and +83C/T polymorphisms were analyzed by RFLP-PCR in 334 individuals from a Brazilian elderly cohort. APOA1 polymorphisms were associated with age-related morbidities, as well as with triglycerides, total cholesterol, HDL, VLDL, LDL, creatinine, urea, albumin, glycated hemoglobin and fasting glucose serum levels. Allele frequencies were 0.102 and 0.21, respectively, for -75A and +83T. -75G allele showed significant association with hypertension (P = 0.001). An association between +83C allele and obesity was observed (P = 0.040) and this allele also showed an association with hypertension in the presence of cardiovascular disease (P = 0.047). Moreover, +83T allele was associated with lower glycated hemoglobin values (P = 0.026). To our knowledge, there is no data associating this polymorphism with glycated hemoglobin. Furthermore, individuals carrying AT haplotype have lower risk for developing hypertension (P = 0.0002), while GT haplotype carriers present decreased risk to develop obesity comparing to GC haplotype (P = 0.025). APOA1 polymorphisms analysis may be a useful tool to identify risk factors for subjects and families and clarify the physiopathological role of these polymorphisms in age-related diseases, such as hypertension and obesity.

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“…In addition, HDL metabolism is governed by lipoprotein lipase and hepatic lipase in such a way that lipoprotein lipase-mediated hydrolysis of triglyceride-rich lipoproteins enhances the incorporation of lipoprotein surface constituents to HDL [22, 25] and that hepatic lipase stimulates HDL triglyceride hydrolysis [25] and preβ-HDL generation [26]. Consequently, common genetic variations of these proteins involved in the metabolism of HDL may interact with one another, and may also affect the plasma HDL-C levels [27,28,29,30]. In individuals with M823 homozygotes, their HDL-C levels are supposed to be high.…”

Section: Discussionmentioning

confidence: 99%

ATP-Binding Cassette Transporter A1 Gene I823M Polymorphism Affects Plasma High-Density Lipoprotein Cholesterol Level and Modifies the Effect of Low High-Density Lipoprotein Cholesterol on the Risk of Coronary Artery Disease

Tsai¹,

Hwang²,

Chiang³

et al. 2007

Cardiology

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Background: TheI823M polymorphism of the ATP-binding cassette transporter A1 (ABCA1) gene has been reported to affect plasmahigh-density lipoprotein cholesterol (HDL-C) level. Information about its relationship to coronary artery disease (CAD) is limited. Methods and Results: We included 205 patients with angiographically documented CAD and 201 controls from the general population. We found thatI823M polymorphism was a significant source of variation of HDL-C (p = 0.024 after adjustment for age, sex, body mass index, smoking and alcohol drinking). Subjects with M823/M823 homozygotes (n = 103) had a higher HDL-C than those with I823/I823 or I823/M823 genotype (n = 98) (50.5 ± 9.7 vs. 47.6 ± 10.1 mg/dl, p = 0.039). I823M polymorphism was not a predictor of CAD in multivariate analysis (adjusted odds ratio = 1.5 [0.9–2.5], p = 0.145). However, it interacted with low HDL-C level to increase the risk of CAD. The odds ratio of CAD with M823 homozygosity was 5.3 (2.0–20.0) in patients with HDL-C ≤35 mg/dl, but was only 1.0 (0.5–2.0) in those with HDL >40 mg/dl (p = 0.039 for interaction). Conclusions: M823 variant of the ABCA1 gene was associated with a higher HDL-C. Furthermore, I823M polymorphism interacted with low-HDL-C on the risk of CAD. It served as a marker to identify high-risk patients for CAD in subjects with low-HDL-C.

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Association of two apolipoprotein A‐I gene MspI polymorphisms with high density lipoprotein (HDL)‐cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early‐onset type 2 diabetes

Abstract: The -75AA genotype was associated with higher HDL-cholesterol levels in the selected healthy, but not diabetic, subjects. The 83T allele was associated with greater indices of obesity in the diabetic patients, and with higher HDL-cholesterol in heterozygous healthy male subjects.

Cited by 16 publications

References 39 publications

Influência de combinações genéticas nos níveis de HDL-c em uma população do sul do Brasil

Influência de combinações genéticas nos níveis de HDL-c em uma população do sul do Brasil

Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

ATP-Binding Cassette Transporter A1 Gene I823M Polymorphism Affects Plasma High-Density Lipoprotein Cholesterol Level and Modifies the Effect of Low High-Density Lipoprotein Cholesterol on the Risk of Coronary Artery Disease

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