Association of UCMA levels in serum and synovial fluid with severity of knee osteoarthritis

Okuyan, Hamza Malik; Terzi̇, Menderes Yusuf; Özcan, Oğuzhan; Kalacı, Aydıner

doi:10.1111/1756-185x.13682

Cited by 13 publications

(17 citation statements)

References 32 publications

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“…This is in line with our observations during DMM-induced OA in mice, showing an increase in Ucma/GRP expressing articular chondrocytes [26]. Ucma/GRP levels in synovial fluid have also been shown to be elevated in OA patients and they positively correlated to disease stage [100]. Together these findings suggest that Ucma/GRP is a potent protector of cartilage during OA and the upregulation of Ucma/GRP in articular cartilage during OA may represent a repair response to damaged cartilage.…”

Section: Ucma/grpsupporting

confidence: 92%

Vitamin K-Dependent Proteins in Skeletal Development and Disease

Stöck

Schett

2021

IJMS

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Vitamin K and Vitamin K-dependent proteins (VKDPs) are best known for their pivotal role in blood coagulation. Of the 14 VKPDs identified in humans to date, 6 play also important roles in skeletal biology and disease. Thus, osteocalcin, also termed bone Gla-protein, is the most abundant non-collagenous protein in bone. Matrix Gla protein and Ucma/GRP on the other hand are highly abundant in cartilage. Furthermore, periostin, protein S, and growth arrest specific 6 protein (GAS 6) are expressed in skeletal tissues. The roles for these VKDPs are diverse but include the control of calcification and turnover of bone and cartilage. Vitamin K plays an important role in osteoporosis and serum osteocalcin levels are recognized as a promising marker for osteoporosis. On the other hand, matrix Gla protein and Ucma/GRP are associated with osteoarthritis. This review focuses on the roles of these three VKDPs, osteocalcin, matrix Gla protein and Ucma/GRP, in skeletal development and disease but will also summarize the roles the other skeletal VKDPs (periostin, protein S and GAS6) in skeletal biology.

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Section: Ucma/grpsupporting

confidence: 92%

Vitamin K-Dependent Proteins in Skeletal Development and Disease

Stöck

Schett

2021

IJMS

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“…In contrast, the serum levels of total COMP were associated with knee but not hip OA suggesting that D-COMP may be joint specific, 44 for yet unclear reasons. Finally, in 2017, Lorenzo et al developed two automated assays against total COMP and COMP neoepitope-S 77 . The ratio of these two assays could distinguish between progressors and nonprogressors for patients with RA.…”

Section: Methodsmentioning

confidence: 99%

Soluble biological markers in osteoarthritis

Rousseau

Chapurlat

Garnero

2021

Therapeutic Advances in Musculoskeletal

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In recent years, markers research has focused on the structural components of cartilage matrix. Specifically, a second generation of degradation markers has been developed against type II collagen neoepitopes generated by specific enzymes. A particular effort has been made to measure the degradation of minor collagens III and X of the cartilage matrix. However, because clinical data, including longitudinal controlled studies, are very scarce, it remains unclear whether they will be useful as an alternative to or in combination with current more established collagen biological markers to assess patients with osteoarthritis (OA). In addition, new approaches using high-throughput technologies allowed to detect new types of markers and improve the knowledge about the metabolic changes linked to OA. The relative advances coming from phenotype research are a first attempt to classify the heterogeneity of OA, and several markers could improve the phenotype characterization. These phenotypes could improve the selection of patients in clinical trials limiting the size of the studies by selecting patients with OA characteristics corresponding to the metabolic pathway targeted by the molecules evaluated. In addition, the inclusion of rapid progressors only in clinical trials would facilitate the demonstration of efficacy of the investigative drug to reduce joint degradation. The combination of selective biochemical markers appears as a promising and cost-effective approach to fulfill this unmet clinical need. Among the various potential roles of biomarkers in OA, their ability to monitor drug efficacy is probably one of the most important, in association with clinical and imaging parameters. Biochemical markers have the unique property to detect changes in joint tissue metabolism within a few weeks.

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“…Osteoarthritis (OA) is the most common degenerative joint disease [1,2]. It is estimated that it affects about 10-20% of the population over 60 years of age [3][4][5][6]. It is characterised by a progressive process, which after years leads to the destruction of joints [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Serum and synovial fluid concentrations of interleukin-18 and interleukin-20 in patients with osteoarthritis of the knee and their correlation with other markers of inflammation and turnover of joint cartilage

et al. 2020

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Introduction: Osteoarthritis (OA) is the most common degenerative joint disease, and its aetiology is not entirely known. The aim of the study was to evaluate the involvement of interleukin-18 (IL-18) and interleukin-20 (IL-20) in the pathogenesis of knee OA and their correlations with other markers of inflammation and destruction of joint cartilage, as well as clinical and radiological changes. Material and methods: The study included 25 patients with knee OA and a control group. The concentration of IL-18, IL-20, IL-6, MMP-1, MMP-3, COMP, PG-AG, and YKL-40 in serum and synovial fluid (SF) were determined. We also evaluated radiological lesions of the knee joint according to the Kellgren-Lawrence (K-L) scale, and clinical severity of the disease according to Western Ontario and McMaster Universities Osteoarthritis Index (WOM-AC) and Lequesne Index. Results: The concentrations of IL-18 and IL-20 were statistically significantly higher in serum of patients with OA than in the control group (106.00 ±189.76 pg/ml vs. 16.73 ±16.99 pg/ml, p < 0.001, 17.69 ±13.45 pg/ml vs. 9.76 ±9.00 pg/ml, p < 0.014). Serum concentration of IL-18 positively correlated with MMP-3 (R = 0.58; p = 0.006) and YKL-40 (R = 0.48; p = 0.002). The degree of radiological advancement of OA (K-L scale) correlated positively with clinical evaluation (WOMAC, R = 0.74, p ≤ 0.001; Lequesne Index, R = 0.57, p = 0.003). Conclusions: The analysis of ROC curves showed that IL-20 as well as COMP, MMP-3, and YKL-40 may be diagnostic markers of knee OA. The observations indicate that IL-18 potentially mediates mainly in intra-articular processes and IL-20 could be primarily responsible for the systemic inflammatory reaction.

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Association of UCMA levels in serum and synovial fluid with severity of knee osteoarthritis

Cited by 13 publications

References 32 publications

Vitamin K-Dependent Proteins in Skeletal Development and Disease

Vitamin K-Dependent Proteins in Skeletal Development and Disease

Soluble biological markers in osteoarthritis

Serum and synovial fluid concentrations of interleukin-18 and interleukin-20 in patients with osteoarthritis of the knee and their correlation with other markers of inflammation and turnover of joint cartilage

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