Association of Uric Acid with Metabolic Syndrome in Men, Premenopausal Women and Postmenopausal Women

Li, Yongqiang; Chen, Shanying; Shao, Xiaofei; Guo, Jia; Liu, Xinyu; Liu, Ai Qun; Zhang, Ying; Wang, Honglei; Li, Bin; Deng, Kangping; Liu, Qin; Holthöfer, Harry; Zou, Hequn

doi:10.3390/ijerph110302899

Cited by 46 publications

(33 citation statements)

References 36 publications

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“…In line with previous studies [21][22][23] we reported higher serum uric acid level in women with MetS, comparing to those without MetS. Moreover, in a prospective study conducted by Zurlo et al [24] high serum uric acid levels significantly and independently predicted MetS in older women, but not in men, over a 4.4-year follow-up.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Jovanović¹,

Klisić²,

Kavarić³

et al. 2016

Tim Med Glas

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Summary:Aim: The data regarding the prevalence of metabolic syndrome (MetS) among postmenopausal women in Montenegro is limited. Therefore, the aim of this study was to evaluate this prevalence and to examine its association with serum uric acid level, an established cardiometabolic risk factor. Methods: A total of 242 postmenopausal women (aging 43-68) were included. Fasting glucose, lipid parameters, and uric acid were determined with the standard procedure. Blood pressure and anthropometric parameters were obtained. MetS was diagnosed according to the modified US National Cholesterol Education Program Adult Treatment Panel III guidelines. Results: The prevalence of MetS in postmenopausal women was 42.1%. The most prevalent component was abdominal obesity (65.3%), following by hypertension (systolic blood pressure and diastolic blood pressure accounting for 54.1% and 49.2% respectively), hyperglycemia (40.5%), and dyslipidemia (high triglycerides and low HDL-c level accounting for 30.2% and 25.2% respectively). Uric acid levels were significantly higher in postmenopausal women with MetS than in those without MetS (P<0.001). Moreover, a significantly higher number of patients with MetS as compared to subjects without diagnosed MetS across uric acid tertiles was found (χ2=27.02, P<0.001). Conclusion: MetS is highly prevalent among postmenopausal women in Montenegro and correlated with higher uric acid level. Abdominal obesity is the most prevalent feature of the syndrome. This suggests the importance of reducing obesity and lowering uric acid level in prevention of cardiometabolic diseases. Keywords:abdominal obesity, metabolic syndrome, postmenopausal, uric acid Sažetak:Cilj: Nema podataka o prevalenci metaboličkog sindroma (MetS) kod žena u periodu postmenopauze u Crnoj Gori. Stoga je cilj studije bio da se utvrdi ova prevalenca i ispita povezanost MetSa sa mokraćnom kiselinom u serumu, poznatim kardiometaboličkim faktorom rizika. Metode: U studiju su uključene 242 žene u postmenopauzi (starosti 43-68 godina). Glikemija našte, lipidni status i mokraćna kiselina su određivani standardnom procedurom. Mereni su i krvni pritisak i antropometrijski parametri. MetS je dijagnostikovan prema modifikovanim smernicama Američkog nacionalnog programa za edukaciju o holesterolu -Preporuke panela III za lečenje odraslih. Rezultati: Prevalenca MetS-a kod žena u postmenopauzi je iznosila 42,1%. Najučestalija komponenta je bila abdominalna gojaznost (65,3%), potom hipertenzija (sistolna -54,1% i dijastolna -49,2%), hiperglikemija (40,5%), dislipidemija (hipertrigliceridemija -30,2%) i niske vrednosti lipoproteina velike gustine (HDL-holesterol -25,2%). Srednje vrednosti serumske mokraćne kiseline bile su značajno više kod žena sa MetS-om u poređenju sa kontrolnom grupom (P<0,001). Takođe, značajno veći broj ispitanica sa MetS-om je zabeležen u tercilnoj grupi sa najvišom koncentracijom mokraćne kiseline u serumu (χ 2 =27,02; P<0,001). Zaključak: Zabeležena je visoka prevalenca MetS-a kod žena u postmenopauzi u Crnoj Gori, kao ...

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Section: Discussionsupporting

confidence: 91%

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Jovanović¹,

Klisić²,

Kavarić³

et al. 2016

Tim Med Glas

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“…[1–5] Several epidemiologic studies showed that serum urate (SU) levels were lower in cigarette smokers than non-smokers. [6–11] Only one recent publication from the Framingham Heart Study (FHS) cohort has examined the association between smoking and risk of gout and reported a lower risk of gout among smokers, only in men but not in women. [12] However, information on dose and duration of smoking was not available in the FHS.…”

mentioning

confidence: 99%

Cigarette Smoking and the Risk of Incident Gout in a Prospective Cohort Study

Teng

Pan

Yuan

et al. 2016

Arthritis Care & Research

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Objective Cigarette smoking is shown to reduce serum urate. However its impact on risk of gout is unknown. We examined the relationship between cigarette smoking and gout risk prospectively examined in this Asian cohort. Methods We analyzed the data from the Singapore Chinese Health Study, a cohort of 63,257 Chinese aged 45–74 years at recruitment in 1993–98. Information on cigarette smoking and other lifestyle factors was collected through in-person interview at recruitment. This analysis included 53,213 participants who participated in either follow-up 1 (1999–2004) and/or follow-up 2 interviews (2006–2010). Cox proportional hazards models were used to assess the relationship between cigarette smoking and gout risk. Results A total of 2,244 incident cases of physician-diagnosed gout were identified after a mean follow-up of 11.1 years. Among men, compared to never smokers, the risk of gout in current smokers was decreased by 27% [hazard risk (HR)=0.73; 95% confidence interval (CI)=0.63–0.84]. This risk reduction was greater in lean male smokers (HR=0.69; 95% CI=0.57–0.83) than overweight smokers (HR=0.87; 95% CI=0.67–1.13) (p for interaction=0.09). This inverse association with smoking was rapidly attenuated to become null even in former smokers who had recently quit smoking. Conversely, there was no association between smoking and gout risk in women. In a companion cross-sectional study, current smokers had significantly lower levels of serum urate than former and never smokers, and this observation was present in men and not women. Conclusion Current smoking is associated with lower risk of gout in men in this Asian cohort.

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“…Birçok çalışmada yüksek serum ÜA seviyelerinin, KVH risk faktörleri, KVH ve KVH progresyonu ile ilişkili olduğu gösterilmiştir [3][4][5][6]. Serum ÜA ile obezite, dislipidemi, hipertansiyon, bozulmuş glukoz metabolizması gibi KVH risk parametrelerinin ilişkisini açıklamak için birçok sebep ileri sürülmüştür.…”

Section: Discussionunclassified

Uric acid levels in metabolically healthy and unhealthy obese patients

Akbaş¹

2014

Diclemedj

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Objective: In this study, we aimed to investigate the difference of uric acid levels between metabolically healthy and unhealthy obese individuals. Methods:Patients of internal medicine and endocrinology outpatient clinics who admitted with the complaint of overweight were separated into two groups, by diagnostic criteria for metabolic syndrome, as metabolically healthy obese and metabolically unhealthy obese individuals. Total of 193 women aged between 18 to 70 years were enrolled into study.Results: Statistically significant differences were determined regarding waist circumference (p=0.038), HOMA-IR (p<0.001) and uric acid levels (p=0.001) between metabolically healthy obese and metabolically unhealthy obese patients while high-sensitive CRP levels (p>0.05) were not differ between these groups. When patients were separated into two groups according to uric acid median, the rate of metabolic syndrome found to be increased in high uric acid group (p=0.021). A correlation analysis showed that uric acid was significantly associated with number of metabolic syndrome parameters (r=0.270, p<0.001) beyond presence of metabolic syndrome. Conclusion:In the fact of determined relation of uric acid with the insulin resistance and significant difference of uric acid levels between metabolically healthy and nonhealthy obese groups, uric acid can be considered as a cheap, accessible and sensitive parameter for metabolic syndrome and cardiovascular risk factor in obese individuals.Key words: Uric acid, obesity, metabolic syndrome X ÖZET Amaç: Çalışmamızda, metabolik olarak sağlıklı ve sağlık-sız obez bireyler arasında serum ürik asit seviyelerindeki farkların araştırılması amaçlanmıştır.Yöntemler: Çalışmamızda; hastanemiz iç hastalıkları ve endokrinoloji polikliniklerine kilo fazlalığı şikayeti ile baş-vuran hastalarda, metabolik sendrom tanı kriterleri araş-tırılarak, metabolik olarak sağlıklı obezler ve sağlıksız obezler olarak iki grup oluşturuldu. Çalışmaya yaşları 18 ile 70 arasında değişen, toplam 193 kadın katılımcı alındı. Bulgular:Metabolik olarak sağlıklı obezler ve metabolik olarak sağlıksız obezler arasında bel çevresi (p=0,038), HOMA-IR (p<0,001) ve ürik asit seviyeleri (p=0,001) açı-sından istatistiksel olarak anlamlı fark tespit edilirken, yüksek duyarlı c-reaktif protein açısından fark gözlen-medi (p>0,05). Hastalar ürik asit median değerine göre iki gruba ayrıldığında, ürik asit yüksek grupta, metabolik sendrom rastlanma oranının arttığı tespit edildi (p=0,021). Metabolik sendrom ile ilişkisinin yanında, ürik asidin, korelasyon analizinde, metabolik sendrom kriterlerinin sayı-sı ile de anlamlı ilişki tespit edildi (r=0,270, p<0,001).Sonuç: İnsülin direnci ile yakın ilişkisi, metabolik olarak sağlıklı olan ve olmayan obez gruplar arasında fark oluş-turduğu dikkate alındığında, ürik asit, obez bireylerde, bir metabolik sendrom kriteri ve kardiyovasküler hastalık risk belirteci olarak kullanılabilecek ucuz, ulaşılabilir ve duyarlı bir parametredir.Anahtar kelimeler: Ürik asit, obezite, metabolik sendrom X

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Association of Uric Acid with Metabolic Syndrome in Men, Premenopausal Women and Postmenopausal Women

Cited by 46 publications

References 36 publications

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Prevalence of metabolic syndrome among postmenopausal women in Montenegro: Relation to hyperuricemia

Cigarette Smoking and the Risk of Incident Gout in a Prospective Cohort Study

Uric acid levels in metabolically healthy and unhealthy obese patients

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