Cigarette Smoking and the Risk of Incident Gout in a Prospective Cohort Study

Teng, Gim Gee; Pan, An; Yuan, Jian‐Min; Koh, Woon‐Puay

doi:10.1002/acr.22821

Cited by 43 publications

(35 citation statements)

References 39 publications

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“…The explanation here could be similar to that for alcohol usage -it is possible that after diagnosis, patients quit smoking. However, there are studies that have demonstrated similar results to our observation regarding active smoking (Gee Teng et al, 2016). In analyses of male cohorts, ex-smoking was found to be associated with higher concentrations of serum urate and higher prevalence of hyperuricemia compared to current smoking .…”

Section: Discussionsupporting

confidence: 88%

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Risk Factor Analysis for Gout in the Latvian Population

Nagle

Luksa

Moisejevs

et al. 2020

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Communicated by Aivars LejnieksGout (Gr. podagra) is a multifactorial pathology, which means that both genetic and environmental factors play a role in the aetiology of the disease. For these reasons, revealing risk factors could be of very high importance in prevention and treatment of gout. In the present study, we found that a major role in gout predisposition is played by specific alleles in the ABCG2 gene. The study used survey data for 43 gout patients and 99 healthy control individuals who were genotyped for rs2231142. It was found that allelic variant rs2231142 in the ABCG2 gene had the strongest association with gout. Among other co-factors studied, sex, and increased body mass index were associated with gout.

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Section: Discussionsupporting

confidence: 88%

“…In analyses of male cohorts, ex-smoking was found to be associated with higher concentrations of serum urate and higher prevalence of hyperuricemia compared to current smoking . Active smoking has also been associated with lower risk of gout in men in an Asian cohort (Gee Teng et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Risk Factor Analysis for Gout in the Latvian Population

Nagle

Luksa

Moisejevs

et al. 2020

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…In the Framingham study, a high BMI has been observed in patients with gout 23. In addition to obesity, life style factors, including alcohol intake and smoking, were prevalent in the gout group 24–26. Associations between these factors and CRC have been well documented in epidemiological studies 27 28.…”

Section: Discussionmentioning

confidence: 97%

Association of gout and colorectal cancer in Taiwan: a nationwide population-based cohort study

et al. 2019

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ObjectivesThis study aimed to determine colorectal cancer (CRC) risks among patients with gout through a follow-up study on a nationwide population-based cohort that included patients with gout and the general population in Taiwan.ParticipantFrom the Taiwan National Health Insurance Research Database, we identified 28 061 patients who were newly diagnosed with gout between 2000 and 2010 as the study cohort. We randomly selected 84 248 subjects matching in gender, age and baseline year as comparison cohort. The cohorts were followed up until CRC occurrence, withdrawal from the system of National Health Insurance, or Dec. 31, 2013.Primary and secondary outcome measuresCumulative incidences and incidence rate ratios (IRRs) of CRC between two cohorts were examined. The Cox proportional hazards model was used to evaluate risk factors associated with CRC development.ResultsDuring the 13-year follow-up, the incidence rate of CRC development in the gout cohort reached 2.44 per 1000 person-years, which was higher than the 2.13 per 1000 person-years in the control cohort (IRR=1.15; 95% CI 1.04 to 1.26). After adjusting for age, gender, urbanisation status and comorbidities, including hypertension, diabetes and hyperlipidaemia, gout showed no significant association with increased risk of CRC occurrence (adjusted HR=1.03; 95% CI 0.93 to 1.14).ConclusionsSimilar risks of CRC incidence were observed in patients with and without gout in Taiwan. Allopurinol and colchicine are commonly used as urate-lowering drug and anti-inflammation medication in Taiwan and had been shown to reduce the risk of CRC incidence. Thus, further pharmaco-epidemiological studies should be carried out to specifically assess the role of allopurinol in the relationship between gout and CRC.

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“…37,59 Some evidence has demonstrated that smoking reduced serum UA levels. 36,60,61 So smoking may be a potential confounder for the relationship between serum UA and schizophrenia risk. Considering the confounding effects, we removed those SNPs associated with smoking as well as associated with UA and schizophrenia, and the causal relationship between Figure 2 Genetic risk score GRS UA for schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

<p>Assessment Causality in Associations Between Serum Uric Acid and Risk of Schizophrenia: A Two-Sample Bidirectional Mendelian Randomization Study</p>

Luo¹,

Wen²,

Li³

et al. 2020

CLEP

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Although increasing lines of evidence showed associations between serum uric acid (UA) levels and schizophrenia, the causality and the direction of the associations remain uncertain. Thus, we aimed to assess whether the relationships between serum UA levels and schizophrenia are causal and to determine the direction of the association. Patients and Methods: Two-sample bidirectional Mendelian randomization (MR) analyses and various sensitivity analyses were performed utilizing the summary data from genome-wide association studies within the Global Urate Genetics Consortium and the Psychiatric Genomics Consortium. Secondary MR analyses in both directions were conducted within summary data using genetic risk scores (GRSs) as instrumental variables. Results: Three MR methods provided no causal relationship between serum UA and schizophrenia. Furthermore, GRS approach showed similar results in the three MR methods after adjustment for heterogeneity. By contrast, inverse variance weighted method, weighted median and GRS approach suggested a causal effect of schizophrenia risk on serum UA after adjustment for heterogeneity (per 10-symmetric percentage increase in schizophrenia risk, beta: −0.039, standard error (SE): 0.013, P = 0.003; beta: −0.036, SE: 0.018, P = 0.043; beta: −0.039, SE: 0.013, P = 0.002; respectively). Moreover, in both directions' analyses, the heterogeneity and sensitivity tests suggested no strong evidence of bias due to pleiotropy. Conclusion: Schizophrenia may causally affect serum UA levels, whereas the causal role of serum UA concentrations in schizophrenia was not supported by our MR analyses. These findings suggest that UA may be a useful potential biomarker for monitoring treatment or diagnosis of schizophrenia rather than a therapeutic target for schizophrenia.

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Cigarette Smoking and the Risk of Incident Gout in a Prospective Cohort Study

Cited by 43 publications

References 39 publications

Risk Factor Analysis for Gout in the Latvian Population

Risk Factor Analysis for Gout in the Latvian Population

Association of gout and colorectal cancer in Taiwan: a nationwide population-based cohort study

<p>Assessment Causality in Associations Between Serum Uric Acid and Risk of Schizophrenia: A Two-Sample Bidirectional Mendelian Randomization Study</p>

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