Association of Vascular Endothelial Growth Factor Polymorphisms with Nonproliferative and Proliferative Diabetic Retinopathy

Abstract

VEGF polymorphisms might be a useful predictive marker for the development and progression of DR at an earlier stage of diabetes.

Association Between the VEGF Gene Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis of 4216 Individuals

“…The meta-analysis showed that -634C/G polymorphism C allele and genotypes CC vs CG + GG and CG vs CC + GG had no statistically significant association with DR. The result further verified most former results [13][14][15][16][17][18][19][20][21] . Meta-analysis is a summary analysis method that can combine various similar research results.…”

“…Thus, VEGF5'-untranslated region-634C/G polymorphism is an independent risk factor in DR. However, further studies on the association yielded similar [9][10][11][12] and opposite results [13][14][15][16][17][18][19][20][21] . Even in one country without ethnic diversity, different results were obtained.…”

“…Therefore, the degree of gene VEGF-634C/G polymorphism and its association with DR were systematically analyzed using evidence-based medicine at allele and genotype levels in the present study. A total of 14 case-control studies were retrieved from various populations: three cases each from China [10,11,20] , India [12,13,17] , and Japan [8,9,18] ; two cases from Portland [14,16] ; and one case each from Slovenia [15] , Finland [19] , and Korea [20] . The meta-analysis showed that -634C/G polymorphism C allele and genotypes CC vs CG + GG and CG vs CC + GG had no statistically significant association with DR.…”

Polymorphism of Vascular Endothelial Growth Factor Regio Promoter C(-634)g as a Risk Factor of Balinese Type-2 Diabetic Retinopathy

“…Research by Freathy, et al (2006) in UK, Nakamura, et al (2009) in Japan, and Chun, et al (2010) in Korea results in insignificant risk factor of DR. [4][5][6] This study aims to support DR pathogenesis theory through the role of genetic factor of VEGF C(-634)G polymorphism gene on promoter region to induce DR. Specifically this study observed VEGF C(-634)G Balinese variances gene and VEGF levels for evaluating risk factor of DR.…”

Two Polymorphisms (Rs699947, Rs2010963) in the VEGFA Gene and Diabetic Retinopathy: An Updated Meta-Analysis

“…To date, many studies have investigated the associations between polymorphisms in the VEGFA gene and DR. -634G/C (+405G/C or rs2010963) polymorphism in the 5′-untranslated region and-2578C/A (−2549I/D (in high linkage disequilibrium with -2578C/A) or rs699947) polymorphism in the promoter region of the VEGFA gene are most frequently investigated. However, the results have been inconsistent [5][6][7][8][9][10][11][12][13][14][15][16]. To date, three relevant meta-analyses [17][18][19] have published.…”