Association of vascular parkinsonism with impaired neuronal integrity in the striatum

Ihara, Masafumi; Tomimoto, Hidekazu; Ishizu, Koji; Yoshida, Hiroo; Sawamoto, Nobukatsu; Hashikawa, Kazuo; Fukuyama, Hidenao

doi:10.1007/s00702-006-0610-7

Cited by 25 publications

(14 citation statements)

References 29 publications

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“…The results showed that the patients with dementia exhibited decreased binding of flumazenil in the prefrontal cortex and the anterior insular cortex compared with those without dementia . Furthermore, the patients with parkinsonism showed decreased binding in the basal ganglia and premotor cortex, thereby indicating impairment of the neural network function in the corresponding territory …”

Section: Introductionmentioning

confidence: 97%

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White matter integrity and cognitive dysfunction: Radiological and neuropsychological correlations

Tomimoto

2015

Geriatrics Gerontology Int

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Cerebral white matter (WM) is comprised of nerve fibers interconnecting neurons in the cerebral cortex or the deep structures. With advancing age, WM frequently shows hyperintense lesions in T2-weighted or fluid-attenuated inversion recovery images in both the periventricular and deep WM. Patients with these WM lesions might manifest a variety of symptoms, such as parkinsonism, cognitive impairment, depression and apathy, when these WM lesions become sufficiently confluent and diffuse. However, there are inconsistencies with respect to their clinical significance, because patients with extensive WM lesions might remain asymptomatic. The present review focuses on the pathological mechanism underlying why the loss of integrity of nerve fibers in the WM induces neuropsychological symptoms. Geriatr Gerontol Int 2015; 15 (Suppl. 1): 3-9.

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Section: Introductionmentioning

confidence: 97%

“…Neuronal viability was decreased in the prefrontal and anterior insular cortex of patients with dementia, and in the striatum of patients with parkinsonism. Reproduced from I hara et al . with permission.…”

Section: Introductionmentioning

confidence: 99%

White matter integrity and cognitive dysfunction: Radiological and neuropsychological correlations

Tomimoto

2015

Geriatrics Gerontology Int

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“…Deficits in the GABAergic system are associated with various motor and cognitive disorders such as Huntington disease (Pinborg et al, 2001), primary dystonia (Garibotto et al, 2011), ischemic stroke (Heiss et al, 2004), vascular parkinsonism (Ihara et al, 2007), epilepsy (Galanopoulou, 2010), schizophrenia (Lewis et al, 2005), autism (Fatemi et al, 2009) and major depressive disorder (Luscher and Shen, 2011;Luscher et al, 2011a). However, pharmacological therapies to extrinsically enhance or reduce the GABAergic system are not always sufficient in ameliorating symptoms (Doggett, 2004;Kalia et al, 2013;Frank, 2014;Pilleri and Antonini, 2015;Walker et al, 2015).…”

Section: Pmentioning

confidence: 99%

Neurofeedback Control of the Human GABAergic System Using Non-invasive Brain Stimulation

et al. 2018

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Neurofeedback has been a powerful method for self-regulating brain activities to elicit potential ability of human mind. GABA is a major inhibitory neurotransmitter in the central nervous system. Transcranial magnetic stimulation (TMS) is a tool that can evaluate the GABAergic system within the primary motor cortex (M1) using paired-pulse stimuli, short intracortical inhibition (SICI). Herein we investigated whether neurofeedback learning using SICI enabled us to control the GABAergic system within the M1 area. Forty-five healthy subjects were randomly divided into two groups: those receiving SICI neurofeedback learning or those receiving no neurofeedback (control) learning. During both learning periods, subjects made attempts to change the size of a circle, which was altered according to the degree of SICI in the SICI neurofeedback learning group, and which was altered independent of the degree of SICI in the control learning group. Results demonstrated that the SICI neurofeedback learning group showed a significant enhancement in SICI. Moreover, this group showed a significant reduction in choice reaction time compared to the control group. Our findings indicate that humans can intrinsically control the intracortical GABAergic system within M1 and can thus improve motor behaviors by SICI neurofeedback learning. SICI neurofeedback learning is a novel and promising approach to control our neural system and potentially represents a new therapy for patients with abnormal motor symptoms caused by CNS disorders.

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“…Approximately 50% of atypical parkinsonism patients have FOG [31,32] . Most patients exhibit bilateral bradykinesia and rigidity, characterized predominantly by a shuffling gait [33,34] .…”

Section: Gait Disordermentioning

confidence: 99%

The clinical manifestations and pathophysiology of cerebral small vessel disease

Zhang

Wang

2010

Neurosci. Bull.

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Small vessel disease (SVD) is responsible for brain chronic circular disorder, and accounts for 20%-30% cases of ischemic stroke as well as cerebral hemorrhage, and to a great extent, encephalopathy. Binswanger's disease and multiple small strokes, which are common in older people, are also closely associated with SVD. These disorders often cause decline in cognition, vascular dementia, impairment in gait and balance, mood depression, and urinary incontinence, and often brings great social and economic burdens. SVD-related encephalopathy increases the incidences of fall, disability and death in elderly people. With the aging of the society, more attention should be paid to the importance of early diagnosis and prophylactic treatment of SVD. Here the clinical manifestations and pathophysiology of SVD are reviewed.

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Association of vascular parkinsonism with impaired neuronal integrity in the striatum

Cited by 25 publications

References 29 publications

White matter integrity and cognitive dysfunction: Radiological and neuropsychological correlations

White matter integrity and cognitive dysfunction: Radiological and neuropsychological correlations

Neurofeedback Control of the Human GABAergic System Using Non-invasive Brain Stimulation

The clinical manifestations and pathophysiology of cerebral small vessel disease

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