Association of VEGF Gene Polymorphisms with Diabetic Retinopathy: A Meta-Analysis

Abstract

BackgroundStudies on the association of vascular endothelial growth factor (VEGF) gene -460T/C and -2578C/A polymorphisms with diabetic retinopathy (DR) have reported conflicting results. The aim of the present study was to assess the association by using meta-analysis.MethodsA systematic search of electronic databases (PubMed, EMBASE, Elsevier Science Direct, ISI Web of Science, CBM, CNKI and VIP) was carried out until Sept 18, 2013. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were used to assess the strength of the association.ResultsEleven studies (-460T/C: 6 studies including 932 cases and 722 controls; -2578C/A: 6 studies including 1,071 cases and 1,137 controls) were involved in this meta-analysis. Significant association was found for -460T/C polymorphism (C versus T: OR=1.48, 95%CI=1.07–2.05, P=0.02; TC+CC versus TT: OR=1.78, 95%CI=1.02–3.12, P=0.04; CC versus TT+TC: OR=1.76, 95%CI=1.10–2.81, P=0.02), but not for -2578C/A polymorphism (P>0.05). Similar results were found in the subgroup analysis.ConclusionsThis meta-analysis demonstrates that DR is associated with VEGF gene -460T/C polymorphism, but not -2578C/A polymorphism. Further case-control studies based on larger sample size are still needed, especially for -2578C/A polymorphism.

Diabetic macular oedema: clinical risk factors and emerging genetic influences

“…Several meta‐analyses have been conducted in order to confirm significant associations. VEGFA polymorphisms analysed include −634G > C(rs2010963), +5092C/A (rs2146323), −2578C/A (rs699947), −460T/C (rs833061), +936C/T (rs3025039) and −1154G/A (rs1570360) …”

Three Polymorphisms of Vascular Endothelial Growth Factor (+936C > T, −460C > T, and −2578C > A) and Their Susceptibility to Ovarian Cancer

“…21 To the authors' knowledge, there has not been a previous meta-analysis that comprehensively investigates the association between VEGF gene polymorphisms and OC risk. To address this problem, we conducted a comprehensive meta-analysis to assess and confirm the connections between VEGF gene +936C 9 T, j2578C 9 A, and j460C 9 T polymorphisms with OC susceptibility.…”

Developments in Ocular Genetics

“…The PON1 gene is a major anti-atherosclerotic component of high-density lipoprotein (HDL) 28 . Other recent meta-analyses found that the vascular endothelial growth factor ( VEGF ) gene -460T/C and -634G/C polymorphisms are strongly associated with DR, but the -2578C/A polymorphism is not 29,30 . Interestingly, the CC genotype for the VEGF -634G/C polymorphism is also associated with better visual outcome after anti-VEGF treatment for diabetic macular edema 31 .…”