Association of Vision Loss in Glaucoma and Age-Related Macular Degeneration with IADL Disability

Hochberg, Chad; Maul, Eugenio; Chan, Eugene; Landingham, Suzanne van; Ferrucci, Luigi; Friedman, David S.; Ramulu, Pradeep Y.

doi:10.1167/iovs.12-9469

Cited by 90 publications

(90 citation statements)

References 34 publications

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“…9 Several populationbased and clinical studies have evaluated self-reported disability and impaired VRQOL that result from having glaucoma. [10][11][12][13][14][15][16][17] Patients with bilateral glaucoma and greater VF loss have poorer patient-reported VRQOL (pVRQOL) and more difficulties in daily activities including driving, dependence on others, social functioning, mental health, general vision, distance vision, near vision, color vision, and peripheral vision. 12,14,15 Only a few reports discuss the impact of the VF defect location on various pVRQOL domains.…”

mentioning

confidence: 99%

Patient-Reported Vision-Related Quality of Life Differences Between Superior and Inferior Hemifield Visual Field Defects in Primary Open-Angle Glaucoma

Cheng

Guo²,

Chen

et al. 2015

JAMA Ophthalmol

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IMPORTANCE Previous studies have found that glaucoma is associated with impaired patient-reported vision-related quality of life (pVRQOL) but few, to our knowledge, have assessed how the visual field (VF) defect location impacts the pVRQOL. OBJECTIVE To investigate the associations of VF defects in the superior vs inferior hemifields with pVRQOL outcomes in patients with primary open-angle glaucoma. DESIGN, SETTING, AND PARTICIPANTS Prospective cross-sectional study at a tertiary referral center from March 1, 2012, to January 1, 2013, including patients with primary open-angle glaucoma who had a best-corrected visual acuity in the better eye equal to or better than 20/60 and reliable VF tests. The pVRQOL was assessed by a validated Taiwanese version of the 25-item National Eye Institute Visual Function Questionnaire. Reliable VF tests obtained within 3 months of enrollment were transformed to binocular integrated VF (IVF). The IVF was further stratified by VF location (superior vs inferior hemifield). MAIN OUTCOMES AND MEASURESThe association between each domain of the 25-item National Eye Institute Visual Function Questionnaire and superior or inferior hemifield IVF was determined using multivariable linear regression analysis. RESULTSThe analysis included 186 patients with primary open-angle glaucoma with a mean age of 59.1 years (range, 19-86 years) and IVF mean deviation (MD) of −4.84 dB (range, −27.56 to 2.17 dB). In the multivariable linear regression analysis, the MD of the full-field IVF showed positive associations with near activities (β = 0.05; R 2 = 0.20; P < .001), vision-specific role difficulties (β = 0.04; R 2 = 0.19; P = .01), vision-specific dependency (β = 0.04; R 2 = 0.20; P < .001), driving (β = 0.05; R 2 = 0.24; P < .001), peripheral vision (β = 0.03; R 2 = 0.18; P = .02), and composite scores (β = 0.04; R 2 = 0.27; P = .005). Subsequent analysis showed that the MD of the superior hemifield IVF was associated only with near activities (β = 0.04; R 2 = 0.21; P < .001) while the MD of the inferior hemifield IVF was associated with general vision (β = 0.04; R 2 = 0.12; P = .01), vision-specific role difficulties (β = 0.04; R 2 = 0.20; P = .01), and peripheral vision (β = 0.03; R 2 = 0.17; P = .03).CONCLUSIONS AND RELEVANCE Superior hemifield IVF was strongly associated with difficulty with near activities. Inferior hemifield IVF impacted vision-specific role difficulties and general and peripheral vision. The impact of a VF defect on a patient's pVRQOL may depend not only on its severity, but also on its hemifield location.

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confidence: 99%

Patient-Reported Vision-Related Quality of Life Differences Between Superior and Inferior Hemifield Visual Field Defects in Primary Open-Angle Glaucoma

Cheng

Guo²,

Chen

et al. 2015

JAMA Ophthalmol

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“…9,11–14,31–34 Likely downstream effects of mobility problems owing to vision impairment included less travel outside the home, restriction of physical activity, difficulty with some activities of daily living, and a greater frequency of institutionalization 7,10,35 (also P.Y.R., E. Maul, MD, E. Chan, MS, L.F., D.S.F. ; unpublished data; January 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Detailed descriptions of inclusion criteria for each group are described elsewhere. 10,20,21 Briefly, glaucoma suspect control subjects were required to have a medical record diagnosis of glaucoma suspect and minimal VF loss (better-eye mean deviation [MD] better than −3 dB). Subjects with glaucoma were required to have a medical record diagnosis of glaucoma and abnormal right and left eye VFs with MDs worse than −3 dB.…”

Section: Methodsmentioning

confidence: 99%

“…27 Visual field testing was completed in the prior 12 months on a Humphrey Field Analyzer II (Carl Zeiss Meditec) using the 24-2 Swedish Interactive Testing Algorithm, as described elsewhere. 21 Other variables included in multivariable analysis were participants’ age, sex, race/ethnicity, employment status, marital status, education, day of week (weekday vs weekend), and population density for participants’ home location based on 2010 US Census track population.…”

Section: Methodsmentioning

confidence: 99%

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Alteration of Travel Patterns With Vision Loss From Glaucoma and Macular Degeneration

et al. 2013

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“…23 Specifically, the presence of vision loss in AMD and field loss in glaucoma were associated with functional disability. 24 The presence of AMD was an independent risk factor for functional disability and impaired ADL performance, after adjusting for walking disability, hospital admissions, and other comorbidities. 25 In a year-long analysis of over 1000 individuals aged 65 or older living in the community, those with visual impairment were 2.5 times more likely to experience functional decline than unimpaired elderly patients after adjusting for age, sex and cognitive status (95% CI 1.37–4.48).…”

Section: Physical and Functional Disabilitymentioning

confidence: 91%

Eye Care Disparities and Health-Related Consequences in Elderly Patients with Age-Related Eye Disease

Umfress

Brantley

2016

Seminars in Ophthalmology

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The elderly population in the United States (age 65 and older) is growing rapidly, estimated by the U.S. Census Department to reach 83.7 million by 2050.1 Visual impairment increases with age among all racial and ethnic groups.2 In the elderly, the most common culprits for vision loss are cataract, glaucoma, and age-related macular degeneration (AMD).2 In the developed world, vision loss from cataract has been dramatically reduced by increased access to cataract surgery. However, AMD and glaucoma lead to irreversible vision loss without early diagnosis and intervention. In the U.S., cases of AMD are expected to double by 2050, reaching 17.8 million among patients age 50 or older.3 Similarly, cases of glaucoma are expected to reach 5.5 million by 2050, an increase of over 90% from 2014.3 The visually impaired elderly face disparities in access to eye care, and subsequent general medical and psychosocial complications.

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Association of Vision Loss in Glaucoma and Age-Related Macular Degeneration with IADL Disability

Abstract: VA loss in AMD and severe VF loss in glaucoma are associated with self-reported difficulties with IADLs. These limitations become more likely with increasing magnitude of VA or VF loss.

Cited by 90 publications

References 34 publications

Patient-Reported Vision-Related Quality of Life Differences Between Superior and Inferior Hemifield Visual Field Defects in Primary Open-Angle Glaucoma

Patient-Reported Vision-Related Quality of Life Differences Between Superior and Inferior Hemifield Visual Field Defects in Primary Open-Angle Glaucoma

Alteration of Travel Patterns With Vision Loss From Glaucoma and Macular Degeneration

Eye Care Disparities and Health-Related Consequences in Elderly Patients with Age-Related Eye Disease

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