Association of Vision Loss With Cognition in Older Adults

Chen, Stephanie P.; Bhattacharya, Jay; Pershing, Suzann

doi:10.1001/jamaophthalmol.2017.2838

Cited by 222 publications

(164 citation statements)

References 38 publications

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“…8 Reduced engagement in these cognitively stimulating activities may lead to brain reserve deficits, resulting in decline in cognitive function. [9][10][11][12][13] In this regard, several cross-sectional studies 12,[14][15][16][17] found a significant association between VI and decline in cognitive function. However, longitudinal reports [5][6][7]18 in this area are currently scarce and nonconclusive.…”

Section: Introductionmentioning

confidence: 99%

Association Between Visual Impairment and Decline in Cognitive Function in a Multiethnic Asian Population

et al. 2020

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IMPORTANCE With the rapidly aging population, the burden of visual impairment (VI) and cognitive decline is expected to increase. Previous cross-sectional studies suggest an association between these 2 health outcomes. However, few longitudinal reports have examined this association, and to our knowledge, no studies have been performed in Asian populations. Further investigation on this association may help to better identify individuals at risk of cognitive decline. OBJECTIVE To examine the longitudinal association between VI and decline in cognitive function in a multiethnic Asian population. DESIGN, SETTING, AND PARTICIPANTSIn this longitudinal, population-based, prospective cohort study, Chinese, Indian, and Malay adults 60 years or older at baseline were recruited from the Singapore Epidemiology of Eye Diseases (SEED) study. At baseline, participants from the SEED study were recruited under 3 studies: the Singapore Malay Eye Study (SiMES;, the Singapore

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Section: Introductionmentioning

confidence: 99%

Association Between Visual Impairment and Decline in Cognitive Function in a Multiethnic Asian Population

et al. 2020

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“…Currently, there is not a gold standard cut-off point for the CERAD, DSST and Animal Fluency test to identify low cognitive performance. Therefore, we used the 25th percentile of the score, the lowest quartile, as the cut-off point, which is consistent with methods used in the published literature [41]. Furthermore, considering that age has a significant effect on cognitive performance, the score was further categorized based on age (60 to < 70 years, 70 to < 80 years, and ≥ 80 years).…”

Section: Cognitive Performance Assessmentmentioning

confidence: 99%

Association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in older adults: National Health and nutrition examination Survey (NHANES) 2011–2014

Dong

et al. 2020

Nutr J

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Background: Current evidence on the association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance is inconsistent. Therefore, the aim is to explore the association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in the U.S. noninstitutionalized population of older adults.Methods: We used data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Intakes of ω-3 and ω-6 fatty acids were obtained through two 24-h dietary recalls and were adjusted by energy. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer's disease (CERAD) Word Learning sub-test, Animal Fluency test and Digit Symbol Substitution Test (DSST). For each cognitive test, people who scored lower than the lowest quartile in each age group were defined as having low cognitive performance. Binary logistic regression and restricted cubic spline models were applied to evaluate the association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance. Results: A total of 2496 participants aged 60 years or older were included. In the full-adjusted model, the odds ratios (ORs) with 95% confidence interval (CI) of CERAD test score, Animal Fluency test score and DSST test score were 0.58 (0.38-0.88), 0.68 (0.47-0.99) and 0.59 (0.37-0.92) for the highest versus lowest tertile of dietary ω-3 fatty acids intake, respectively; the ORs with 95% CI of CERAD test score, Animal Fluency test score and DSST test score were 0.48 (0.31-0.75), 0.60 (0.40-0.92) and 0.50 (0.34-0.75) for the highest versus lowest tertile of dietary ω-6 fatty acids intake, respectively. The association between ω-6: ω-3 ratio and cognitive performance was not statistically significant in three tests. In dose-response relationship analysis, L-shaped associations were apparent for ω-3 and ω-6 fatty acids intake with CERAD test score, Animal Fluency test score and DSST test score. Conclusions:Dietary ω-3 and ω-6 fatty acids intake might be inversely associated with low cognitive performance.

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“…Aging, Demographics and Memory Study (ADAMS) found evidence of an independent association between untreated poor vision and dementia. 19 Other epidemiological studies conducted in the United States, the Netherlands, Australia, and Mexico have also suggested an association between age-related eye conditions and cognitive decline, [20][21][22][23][24][25][26] but these studies have focused on cognitive decline rather than dementia, [22][23][24][25] had small sample sizes, 19 were not conducted in the United Kingdom, or analyzed only individuals aged 65 and older. [21][22][23][24][25] The current study cross-sectionally and longitudinally investigated whether self-rated impaired vision was independently associated with dementia in a representative sample of adults aged 50 and older in England.…”

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confidence: 99%

Vision Impairment and Risk of Dementia: Findings from the English Longitudinal Study of Ageing

Davies‐Kershaw

Hackett

Cadar

et al. 2018

J American Geriatrics Society

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Our study confirms and extends findings from other countries, demonstrating cross-sectional associations between moderate and poor self-rated vision and dementia in England in all participants aged 50 and older and longitudinally over an 11-year period in those aged 50 to 69. These results help establish vision loss as a risk factor for dementia, although it is unclear why. Research is needed to determine whether screening and treatment for vision loss may slow cognitive decline.

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Association of Vision Loss With Cognition in Older Adults

Abstract: IMPORTANCE Visual dysfunction and poor cognition are highly prevalent among older adults; however, the relationship is not well defined.OBJECTIVE To evaluate the association of measured and self-reported visual impairment (VI) with cognition in older US adults.

Cited by 222 publications

References 38 publications

Association Between Visual Impairment and Decline in Cognitive Function in a Multiethnic Asian Population

Association Between Visual Impairment and Decline in Cognitive Function in a Multiethnic Asian Population

Association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in older adults: National Health and nutrition examination Survey (NHANES) 2011–2014

Vision Impairment and Risk of Dementia: Findings from the English Longitudinal Study of Ageing

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