Association of Vitamin D Deficiency with Hyperandrogenism in Females with Polycystic Ovarian Syndrome

Hanif, Fouzia; Ilyas, Nasim; Qamar, Tehmina

doi:10.5455/ijcbr.2018.42.07

Cited by 8 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There was no notable disparity in vitamin D insufficiency between the non-obese and obese cohorts, as the findings indicated that 22 (or 37%) of non-obese women and 19 (or 31%) of obese women experienced a deficiency in vitamin D. The p-value for this difference was 0.054. 18 In women with PCOS, it was discovered that 58.0% of them had a lack of vitamin D. This finding corresponds to the results of a previous study by Kim et al in the Korean population, which found that 57.9% of women with PCOS also had a deficiency in vitamin D. 15 Wehr et al found a lower frequency rate of 31.2% in Austria compared to other rates. 19 The prevalence of vitamin D deficiency did not vary significantly across different age groups, specifically between 17-30 and 31-44 years (57.6% versus 57.1%, respectively; p=0.643), nor among different BMI groups, such as obese versus non-obese individuals (64.8% versus 52.3%, respectively; p=0.045).…”

Section: Discussionsupporting

confidence: 80%

Association of Vitamin D Deficiency in Pakistani Women with Polycystic Ovarian Syndrome

Siddique,

Ahuja,

Baloch

et al. 2023

PJMHS

View full text Add to dashboard Cite

Objective: Females suffering from polycystic ovarian syndrome have an increased likelihood of experiencing a deficiency in vitamin D. Methods: The Obstetrics and Gynecology department at Indus Medical College Tando Muhammad Khan, conducted a cross-sectional study for six months. The study aimed to investigate 160 women aged 17–44 who presented with the polycystic ovarian syndrome. The researchers collected blood samples from the participants and measured their vitamin D levels. If the serum levels of 25-hydroxyvitamin D3 were less than 20ng/ml, the participants were considered vitamin D deficient. The researchers obtained written informed consent from all participants and used SPSS version 20 to enter and analyze the collected data. Results: The study included patients aged between 17 and 44 years old, with an average age of 25.721 ± 7.56 years. The majority of patients (n=118, 73.7%) fell within the 17-30 age range, while 52 patients (26.0%) were between the ages of 32-45. In the study group, 74 patients (46.25%) were classified as obese. However, there was no significant contrast in the occurrence of vitamin D insufficiency among different age brackets (17-30 vs. 31-44 years) or body mass index classifications (overweight vs. non-overweight). Specifically, the percentages were 57.6% vs. 57.1% for age categories and 64.8% vs. 52.3% for body mass index divisions, correspondingly, with p-values of 0.643 and 0.045. Conclusion: Among females with polycystic ovary syndrome (PCOS), the prevalence of insufficient levels of vitamin D was determined to be 58.0%. Nonetheless, there were no significant differences in the occurrence of vitamin D insufficiency across different age and BMI groups. Keywords: Vitamin D deficiency, polycystic ovarian syndrome, obesity

show abstract

Section: Discussionsupporting

confidence: 80%

Association of Vitamin D Deficiency in Pakistani Women with Polycystic Ovarian Syndrome

Siddique,

Ahuja,

Baloch

et al. 2023

PJMHS

View full text Add to dashboard Cite

show abstract

“…re, it has been found to be effective in controlling the secretion of human placental lactogen (HPL), estrogen and progesterone [12]. Vitamin D deficiency is associated with preeclampsia [13], polycystic ovary syndrome [14], endometriosis [15], and miscarriage [16]. In animal models, vitamin D deficiency is reported to cause a reduction in the chances of pregnancy, an increase in pregnancy complications, uterine hypoplasia and infertility [17].…”

Section: Introductionmentioning

confidence: 99%

Calcitriol Effect on Outcomes of in Vitro Fertilization in Infertile Women with Vitamin D Deficiency: A Double-Blind Randomized Clinical Trial

Doryanizadeh

Behbahani

Parsanezhad

et al. 2020

Z Geburtshilfe Neonatol

View full text Add to dashboard Cite

Introduction Recent studies have addressed the role of micronutrients in fertilization, such as vitamin D. The present study aims to explore the effects of using calcitriol, an active form of vitamin D, on IVF results in women with vitamin D deficiency. Method This double-blinded randomized clinical trial was done on 180 infertile women, undergone IVF treatment. Out of them, 95 were found to have vitamin D deficiency (blood serum 25-dihydroxy vitamin D <30 ng/ml). Fifty one women in experimental group were treated with two 0.25 µg calcitriol pills daily during 4 weeks (discontinued 8 hours prior to the embryo transfer) and 44 subjects to the placebo group (mean vitamin D deficiency 27.5 ±1.8 in case group vs. 27.6±1.8 in control group, P>0.05). Final analysis includes outcomes of chemical and clinical pregnancy was done on 74 women (including 36 in case and 38 in control group). Results Our study showed that in the experimental group, chemical pregnancy success was significantly higher than that in the control group, 31.4 vs. 18.2% (P<0.05). However, there were no significant differences between the 2 groups in reaching the clinical pregnancy stage (25.5% in case group vs. 13.6% in control group) and continuation of pregnancy into week 20 (9.8% in case group vs. 11.6% in control group) (P>0.05). Conclusion Calcitriol administration by improving the implantation process can significantly increase the chances of successful IVF cycle results in infertile women with vitamin D deficiency.

show abstract

“…Study participants were assessed for their vitamin D levels. Those having vitamin D deficiency serum concentrations <20ng/ml (Hanif et al, 2019)…”

Section: Methodsmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

View full text Add to dashboard Cite

To compare the effect of vitamin D treatment on total antioxidant capacity (TAOC), paraoxonase 1 (PON1) and anti-müllerian hormone (AMH) in infertile females with and without polycystic ovary syndrome (PCOS) were studied. It was a case-control study involving a total of 180 participants; 114 (63 %) PCOS and 66 (37 %) non-PCOS infertile female subjects from 2020-2022. Study participants received a single injection of vitamin D cholecalciferol (300,000 IU) once in the study period. Serum levels of vitamin D, AMH, TAOC and PON1 were determined before and after treatment. The quantitative variables were calculated by means and standard error of the mean (SE), compared by paired t test; significance at p<0.05. The mean age was comparable in both groups whereas the body mass index (BMI) of PCOS females was higher (p<0.001). Vitamin D and AMH were significantly low in PCOS vs. non-PCOS females (p<0.001). TAOC and PON1 mean levels in both groups were comparable. The biomarker levels improved in both groups after vitamin D treatment more in PCOS females (p<0.001). Vitamin D elicited improvement of oxidative stress in infertile females with and without PCOS, however, the dominant and significant role in PCOS is the one highlighted in our study.

show abstract

Association of Vitamin D Deficiency with Hyperandrogenism in Females with Polycystic Ovarian Syndrome

Cited by 8 publications

References 0 publications

Association of Vitamin D Deficiency in Pakistani Women with Polycystic Ovarian Syndrome

Association of Vitamin D Deficiency in Pakistani Women with Polycystic Ovarian Syndrome

Calcitriol Effect on Outcomes of in Vitro Fertilization in Infertile Women with Vitamin D Deficiency: A Double-Blind Randomized Clinical Trial

Untitled

Contact Info

Product

Resources

About