Association of vitamin D receptor gene polymorphisms with clinical outcomes of dengue virus infection

Alagarasu, Kalichamy; Honap, Tanvi P.; Mulay, A.P.; Bachal, Rupali; Shah, P.S.; Cecilia, D.

doi:10.1016/j.humimm.2012.08.007

Cited by 63 publications

(39 citation statements)

References 29 publications

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“…The known influence of VDR on the immune response [6,7,8] may have contributed to or even accounted for the impact of the VDR rs2228570 polymorphism on allergy. Previous observations revealed an influence of the FokI VDR polymorphism on prevalance and/or clinical course of asthma [27,28], immune type 1 diabetes [77], multiple sclerosis [31], systemic lupus erythematosus [78], graft rejection [79], ulcerative colitis [40], aggressive periodontitis [30] and dengue hemorrhagic fever [80]. …”

Section: Discussionmentioning

confidence: 99%

Impact of Vitamin D Receptor VDR rs2228570 Polymorphism in Oldest Old

Glocke

Läng

Schaeffeler

et al. 2013

Kidney Blood Press Res

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Background: Calcitriol, a key player in the regulation of mineral metabolism, influences, directly or by increasing plasma Ca²⁺ and phosphate levels, a multitude of physiological functions, such as bone mineralization, cell proliferation, immune response, carbohydrate metabolism, blood pressure, platelet reactivity, gastric acid secretion, cognitive function and mood. Calcitriol is mainly effective by stimulation of the Vitamin D receptor VDR. The responsiveness of VDR may be affected by gene variants, such as the FokI polymorphism (rs2228570). The GG gene variant is expected to be more active than the GA or AA gene variant. The present study explored the impact of VDR rs2228570 on survival and health of oldest old individuals (> 90 years). Methods: 101 individuals > 90 years were examined and genotyped. As a result, the prevalence of GG, GA & AA was 36 (10 ♂, 26♀), 52 (24 ♂, 28♀) and 13 (4 ♂, 9♀), respectively, a prevalence not significantly different from the frequency in public available dbSNP and a population (n = 208) of young volunteers (average age 49 years). Results: As compared to carriers of GG, carriers of AA and/or GA displayed significantly (p<0.05) lower diastolic blood pressure (significant only in ♂), higher instrumental activity of daily life (IADL) score and more frequent hospital visits (significant only in ♂), significantly lower prevalence of depression (significant in ♀+♂), renal disease (significant only in ♀), allergy, peptic ulcer and urolithiasis (significant only in ♂), as well as significantly higher prevalence of transitoric ischemic attacks. In a younger population a German version of the NEO-FFI, allowing reliable and valid assessment of personality, revealed decreased neuroticism (significant only in ♂) and increased extraversion in AA carriers. Conclusion: The Vitamin D receptor gene variant VDR rs2228570 has only little impact on life span but may affect a variety of pathophysiologically relevant functions including mood.

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Section: Discussionmentioning

confidence: 99%

Impact of Vitamin D Receptor VDR rs2228570 Polymorphism in Oldest Old

Glocke

Läng

Schaeffeler

et al. 2013

Kidney Blood Press Res

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“…In another study in Pune, India, Alagarasu and others 32 assessed the frequencies of various vitamin D-receptor gene polymorphisms in DF and DHF patients as well as healthy controls. All dengue patients and DF patients were found to have a significantly lower frequency of the haplotype G-C-T (corrected P-value [Pc] = 0.0135) and a higher frequency of the haplotype G-A-T (Pc = 0.000085) compared with healthy controls.…”

Section: Vitamin D Why Vitamin D?mentioning

confidence: 99%

Micronutrients and Dengue

Ahmed

Finkelstein

Stewart

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Dengue virus infection is the most widespread mosquito-borne viral infection in humans and has emerged as a serious global health challenge. In the absence of effective treatment and vaccine, host factors including nutritional status, which may alter disease progression, need investigation. The interplay between nutrition and other infections is well-established, and modulation of nutritional status often presents a simple low-cost method of interrupting transmission, reducing susceptibility, and/or ameliorating disease severity. This review examines the evidence on the role of micronutrients in dengue virus infection. We found critical issues and often inconsistent results across studies; this finding along with the lack of sufficient literature in this field have limited our ability to make any recommendations. However, vitamins D and E have shown promise in small supplementation trials. In summary, the role of micronutrients in dengue virus infection is an exciting research area and needs to be examined in well-designed studies with larger samples.

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“…While there was a non significant difference as regard other parameters ( VDR, a nuclear receptor that binds to the active form of vitamin D. VDR functions is influenced by gene polymorphisms, among which a start codon polymorphism (rs2228570) is the most frequently investigated polymorphisms in the VDR gene [15][16][17].…”

Section: Discussionmentioning

confidence: 99%