Association of vitamin D receptor BsmI gene polymorphism with risk of low bone mineral density in post-menopausal women: a meta-analysis

Abstract

ABSTRACT. The vitamin D receptor BsmI gene polymorphism is reportedly associated with low bone mineral density (BMD) in postmenopausal women, but results from previous studies are conflicting. In the present study, we investigated the association between this polymorphism and the risk of low BMD through a metaanalysis of published studies. A literature search of the Pubmed, Embase, and CNKI databases from inception through July 2013 was conducted. The meta-analysis was performed using the STATA 12.0 software. Crude odds ratios with 95% confidence intervals were used to assess the strength of any association. Eleven case-control studies were included for a total of 1468 low BMD cases and 2177 healthy controls. No significant variation in low BMD risk was detected in any of the genetic models. Further stratified analyses were performed to examine the effect of ethnicity. In the subgroup analysis, no significant association was found in Caucasians and in Asians. The meta-analysis results suggest that the BsmI polymorphism is not associated with low BMD risk in postmenopausal women.

A Candidate Gene Association Study of Bone Mineral Density in an Iranian Population

“…Early work from Keen et al (45) and Spector et al (46) using UK Twin cohorts, as well as the work from Ferrari et al (47), led to the identification of common polymorphisms in the VDR as being associated with BMD and an important target for the treatment of osteoporosis. However, there have been conflicting results (48), and more importantly meta-analyses including this genetic variant have not found consistent evidence for its association with BMD variation or osteoporotic fracture risk (8, 49–51). However, one Iranian study has shown a statistically significant association with the VDR SNP rs2228570 and BMD in females, though they did not examine the SNP rs731246.…”

Study of Vitamin D Receptor Gene Polymorphisms in Egyptian Patients with Primary Osteoporosis

“…These observed phenomena produce long-term mineral loss from the skeleton and low BMD. The initial studies by Morrison et al [26][27][28] suggested that the "B" allele of the BsmI RFLP-site is the risk allele associated with low BMD, other studies either could confirm this [29] , did not find any effect [30] , or reported the opposite (31) .…”