Association of vitamin D status with coronary artery disease in postmenopausal women

Xu, Rui; Li, Yanyan; Ma, Lingling; Yang, Haiming

doi:10.1097/md.0000000000019544

Cited by 9 publications

(2 citation statements)

References 22 publications

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“…The association between vitamin D deficiency and CAD has been investigated in several studies [ 25 , 26 , 27 ]. In 1978, a Danish report initially found that vitamin D levels were significantly lower in patients with stable angina or acute myocardial infarction (AMI) than in controls [ 28 ].…”

Section: Vitamin D and Coronary Artery Diseasementioning

confidence: 99%

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

et al. 2021

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Vitamin D deficiency is a prevalent condition, occurring in about 30–50% of the population, observed across all ethnicities and among all age groups. Besides the established role of vitamin D in calcium homeostasis, its deficiency is emerging as a new risk factor for cardiovascular disease (CVD). In particular, several epidemiological and clinical studies have reported a close association between low vitamin D levels and major CVDs, such as coronary artery disease, heart failure, and atrial fibrillation. Moreover, in all these clinical settings, vitamin deficiency seems to predispose to increased morbidity, mortality, and recurrent cardiovascular events. Despite this growing evidence, interventional trials with supplementation of vitamin D in patients at risk of or with established CVD are still controversial. In this review, we aimed to summarize the currently available evidence supporting the link between vitamin D deficiency and major CVDs in terms of its prevalence, clinical relevance, prognostic impact, and potential therapeutic implications.

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Section: Vitamin D and Coronary Artery Diseasementioning

confidence: 99%

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

et al. 2021

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“…It has been shown in previous studies that in patients with type 2 diabetes, there is a strong association between low levels of vitamin D and coronary artery disease, cerebrovascular disease, and peripheral vascular disease [13,14]. In high-risk diabetics with a UACR > 30 mg/24 hours, low levels of vitamin D are associated with asymptomatic CAD [15].…”

Section: Introductionmentioning

confidence: 95%

The Association Between Vitamin D Deficiency and Angiographic Results in Type 2 Diabetic Patients with Increased Urinary Albumin Excretion Ratio

Mehrpooya,

gharibzadeh,

Ebrahimi

et al. 2024

Preprint

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Background: The association between vitamin D deficiency, proteinuria, and diabetic nephropathy has been shown. This study will examine the relationship between vitamin D deficiency and angiographic coronary artery disease (CAD) severity in patients with type 2 diabetes mellitus (T2DM) increased Urinary Albumin/Creatinine Ratio (UACR). Method: Patients with diabetes referred for coronary angiography were included in this study. Their baseline information was recorded, and the blood and urine samples were sent for laboratory evaluation. Patients then underwent angiography. Results: The study included 129 patients. The mean age of the patients was 59.35 ±9.2 years old. A coronary angiography revealed that 62.8% of them had coronary artery involvement. Patients with CAD were divided into three groups: Single-vessel disease (SVD), two-vessel disease (2VD), and three-vessel disease (3VD), and their distribution was 20%, 17%, and 24%, respectively. Only 17.1% of patients had sufficient vitamin D levels, and 40% had vitamin D deficiency. There was a significant relationship between vitamin D deficiency and proteinuria, coronary artery involvement, and its severity. In patients with very severe vitamin D deficiency (vitamin D level <10), 77.8% of them had an elevated Urine Albumin/Creatinine ratio (UACR). Conclusion: Vitamin D deficiency is associated with increased proteinuria, the number of involved coronary vessels, and the severity of coronary artery stenosis. Therefore, it is recommended therapeutic and preventive role of vitamin D in improving and reducing renal and cardiovascular disease be investigated.

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The Importance of Inflammatory State in Vitamin Supplementation Studies

Nikooyeh

Neyestani

2022

Biomarkers in Disease: Methods, Discoveries and Applications

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Association of vitamin D status with coronary artery disease in postmenopausal women

Cited by 9 publications

References 22 publications

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

The Association Between Vitamin D Deficiency and Angiographic Results in Type 2 Diabetic Patients with Increased Urinary Albumin Excretion Ratio

The Importance of Inflammatory State in Vitamin Supplementation Studies

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