Association of Vitamin D Status and Physical Activity with Lipid Profile in Korean Children and Adolescents: A Population-Based Study

Song, Kyungchul; Park, Gihong; Youngik, Choi; Oh, Jun Suk; Choi, Hyo Seong; Suh, Jin‐Suck; Kwon, Ah Reum; Kim, Ho-Seong; Chae, Hyun Wook

doi:10.3390/children7110241

Cited by 13 publications

(10 citation statements)

References 39 publications

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“…In a meta-analysis of eight prospective cohort study, the group with the lower 20% of serum vitamin D levels was associated with increased cardiovascular mortality and all-cause mortality (34). Vitamin D deficiency is also correlated with dyslipidemia (35) and is thought to be more influential in high-fat diets such as KDT.…”

Section: Discussionmentioning

confidence: 99%

Association of hypercalciuria with vitamin D supplementation in patients undergoing ketogenic dietary therapy

Lee

Song

et al. 2022

Front. Nutr.

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BackgroundKetogenic dietary therapy (KDT) is used as an effective treatment for epilepsy. However, KDT carries the risk of bone health deterioration; therefore, vitamin D supplementation is required. Vitamin D replacement therapy in KDT has not been established because it may be related to hypercalciuria/urolithiasis, which are common adverse effects of KDT. Hence, this study aimed to evaluate the dose-dependent association between vitamin D3 and hypercalciuria/urolithiasis in patients undergoing KDT and dose optimization for renal complications.Materials and methodsOverall, 140 patients with intractable childhood epilepsy started 3:1 KDT (lipid to non-lipid ratio) at the Severance Children’s Hospital from January 2016 to December 2019. Regular visits were recommended after KDT initiation. Participants were assessed for height, weight, serum 25-hydroxyvitamin D (25-OH-D3) level, parathyroid hormone level, and ratio of urinary excretion of calcium and creatinine (Uca/Ucr). Kidney sonography was conducted annually. Patients who already had urolithiasis and were taking hydrochlorothiazide before KDT, failed to maintain KDT for 3 months, did not visit the pediatric endocrine department regularly, did not take prescribed calcium and vitamin D3 properly, or needed hospitalization for > 1°month because of serious medical illness were excluded. Data from patients who started diuretic agents, e.g., hydrochlorothiazide, were excluded from that point because the excretion of calcium in the urine may be altered in these patients.ResultIn total, 49 patients were included in this study. Uca/Ucr ratio significantly decreased with increasing levels of 25-OH-D3 (p = 0.027). The odds ratio for hypercalciuria was 0.945 (95% confidence interval, 0.912–0.979; p = 0.002) per 1.0 ng/mL increment in 25-OH-D3 level. Based on findings of receiver operating characteristic curve analysis and Youden’s J statistic, the cut-off 25-OH-D3 level for preventing hypercalciuria was > 39.1 ng/mL at 6 months. Furthermore, the vitamin D3 supplementation dose cut-off was > 49.5 IU/kg for hypercalciuria prevention.ConclusionAn inverse relationship between Uca/Ucr ratio and 25-OH-D3 level was noted, which means that vitamin D supplementation is helpful for preventing hypercalciuria related to KDT. We suggest that the recommended 25-OH-D3 level is > 40 ng/mL for hypercalciuria prevention and that KDT for children with epilepsy can be optimized by vitamin D3 supplementation at 50 IU/kg.

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Section: Discussionmentioning

confidence: 99%

Association of hypercalciuria with vitamin D supplementation in patients undergoing ketogenic dietary therapy

Lee

Song

et al. 2022

Front. Nutr.

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“…30) Another recent study of nationwide representative data of 2581 non-obese children aged 12-18 years revealed that vitamin D deficiency (serum 25[OH]D ≤20 ng/mL) was associated with low HDL-C levels but not with high TC, TG, and LDL-C levels. 31) Despite the inconsistent results for each lipid profile, most studies showed an overall positive association between serum 25 (OH) D levels and favorable lipid profiles. However, it is unclear whether vitamin D supplementation positively affects lipid profiles.…”

Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

“…The vitamin D-deficient group (serum 25[OH]D <20 ng/mL) showed higher serum TG levels and TG/HDL-C ratio than the normal vitamin D level group [ 30 ]. Another recent study of nationwide representative data of 2,581 nonobese children aged 12–18 years revealed that vitamin D deficiency (serum 25[OH]D ≤20 ng/mL) was associated with low HDL-C levels but not with high TC, TG, and LDL-C levels [ 31 ].…”

Section: Pediatric Health Issues Associated With Lipid Profilesmentioning

confidence: 99%

A new perspective on cholesterol in pediatric health: association of vitamin D metabolism, respiratory diseases, and mental health problems

Hong

2022

Clin Exp Pediatr

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Cholesterol, the main structural molecule of cell membranes, is involved in essential functions of the human body. Dyslipidemia is an established risk factor for cardiovascular diseases (CVDs) that is observed even in childhood. To reduce the risk of CVDs in children, several clinical guidelines have been published for the management of pediatric dyslipidemia.However, pediatric dyslipidemia is also associated with several health problems other than CVDs. This article reviews the current data on dyslipidemia-related pediatric health issues.There is strong evidence that low serum vitamin D levels, asthma, and mental health problems may be associated with dyslipidemia in the pediatric population regardless of body mass index. This review also highlights the need for further large-scale population-based studies in the Korean pediatric population to establish effective strategies for promoting children's health.

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“…Lipid profile and atherogenic index (AI) are important predictors of dyslipidemia, atherosclerosis, and cardiovascular disease. Any changes in normal lipid levels put people at greater risk of developing cardiovascular diseases and abnormal endothelial cell function (5).…”

Section: Introductionmentioning

confidence: 99%

“…According to previous studies, regular aerobic exercise plays a significant role in the prevention and control of these diseases (5). However, little is known about the preventative effect of strength training on the risk factors for cardiovascular diseases such as high blood pressure, cholesterol levels, obesity, and type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Eight Weeks of Incremental Pump Body Training on Some Atherogenic Factors in Obese Women With Dyslipidemia

2022

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Background: Dyslipidemia is one of the main risk factors for coronary artery disease, stroke, and peripheral vascular disease. This study aimed to evaluate the effect of eight weeks of incremental pump body training on some atherogenic factors in obese women with dyslipidemia. Materials and Methods: In this quasi-experimental study, 40 obese female subjects in the age range of 30-50 years suffering from dyslipidemia were randomly divided into two groups of body pump training (n=20) and control (n=20). The body pump training program consisted of eight weeks with a frequency of 3 sessions per week for 45 minutes with overload and 48 hours of rest. Data were analyzed using independent samples t test and paired samples t test. Results: The results showed that eight weeks of body pump training significantly decreased triglyceride, cholesterol, low-density lipoprotein (LDL), and atherogenic index (AI) in obese women with dyslipidemia, while there was a significant increase in high-density lipoprotein (HDL) (P˂0.001). Conclusion: The results of this study show that body pump training can properly prevent the progression of dyslipidemia in people suffering this complication.

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Association of Vitamin D Status and Physical Activity with Lipid Profile in Korean Children and Adolescents: A Population-Based Study

Cited by 13 publications

References 39 publications

Association of hypercalciuria with vitamin D supplementation in patients undergoing ketogenic dietary therapy

Association of hypercalciuria with vitamin D supplementation in patients undergoing ketogenic dietary therapy

A new perspective on cholesterol in pediatric health: association of vitamin D metabolism, respiratory diseases, and mental health problems

The Effect of Eight Weeks of Incremental Pump Body Training on Some Atherogenic Factors in Obese Women With Dyslipidemia

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