Association of weight-adjusted-waist index with incident hypertension: The Rural Chinese Cohort Study

Li, Quanman; Qie, Ranran; Qin, Pei; Zhang, Dongdong; Guo, Chunmei; Zhou, Qionggui; Tian, Gang; Liu, Dechen; Chen, Xu; Liu, Leilei; Liu, Feiyan; Cheng, Cheng; Han, Minghui; Huang, Shengbing; Wu, Xiaoyan; Zhao, Yang; Ren, Yongcheng; Zhang, Ming; Lu, Jie

doi:10.1016/j.numecd.2020.05.033

Cited by 69 publications

(51 citation statements)

References 22 publications

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“…and albuminuria. It has been reported that WWI is a newly developed obesity index that has been explored in various fields, particularly related to cardiovascular diseases (9,10,12). We confirmed that WWI had a strong correlation with albuminuria, and the linear positive correlation we found between WWI and albuminuria remained stable in the fully adjusted model.…”

Section: Discussionsupporting

confidence: 83%

“…Similar gender differences were also observed in several studies (34,35). For the non-linear correlation observed in the female groups, we further concluded that the inflection point of WWI was 10.93, which means that the correlation between WWI and albuminuria is meaningful when the WWI of women reaches this threshold, which was similar to the obesity thresholds used in other studies (9,36). In addition, Mexican Americans were considered to have a higher likelihood of albuminuria, which is consistent with previous findings suggesting the role of genetic and unmeasured sociocultural factors (37,38).…”

Section: Bmi Wcsupporting

confidence: 80%

“…Therefore, WWI can draw out the benefits of WC and weaken the correlation with BMI, thus reflecting mainly weight-independent centripetal obesity. Several studies have demonstrated the positive association between WWI with new-onset hypertension, diabetes, and even the all-cause and cardiovascular mortality (9)(10)(11). Kim et al confirmed that WWI could be an indicator of fat and muscle composition changes related to aging commonly applicable to all race/ethnic groups (12).…”

Section: Introductionmentioning

confidence: 99%

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The association between weight-adjusted-waist index and increased urinary albumin excretion in adults: A population-based study

et al. 2022

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AimsThe negative effect of obesity on kidney health has been reported. The association between weight-adjusted-waist index (WWI, a newly developed adiposity index) and albuminuria has not been reported earlier.MethodsThis cross-sectional study was conducted among adults with complete data about WWI and urinary albumin-to-creatinine ratio (ACR) in 2005–2018 National Health and Nutrition Examination Survey (NHANES). WWI was calculated as waist circumference (WC) divided by the square root of weight. Weighted multivariable logistic regression and generalized additive model were employed to explore the independent relationship between WWI with albuminuria and its non-linearity. A two-piecewise linear regression model was used to calculate the threshold effect. Subgroup analysis and interaction tests were also performed.ResultsA total of 36,921 participants were enrolled with a prevalence of albuminuria of 9.32%. The prevalence of albuminuria increased with the higher WWI tertiles (Tertile 1: 5.31%, Tertile 2: 8.23%, Tertile 3: 15.65%). WWI was positively associated with a higher likelihood of albuminuria (OR = 1.28, 95% CI: 1.15–1.43), and this relationship remains stable in subgroups (all P for trend > 0.05). Non-linear positive relationships were detected in females with a breakpoint of 10.93. A positive association between WWI and albuminuria (OR = 1.39, 95% CI: 1.20–1.61) was observed on the right of the breakpoint, while the association on the left was of no statistical significance. WWI showed a stronger correlation with albuminuria (OR = 1.28) than other markers of obesity including body mass index (BMI, OR = 1.02) and WC (OR = 1.01).ConclusionWeight-adjusted-waist index levels were positively related to an increased likelihood of albuminuria in United States adults and showed a stronger relationship than BMI and WC. Our findings indicated that WWI may serve as a simple anthropometric index to predict albuminuria.

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Section: Discussionsupporting

confidence: 83%

Section: Bmi Wcsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

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The association between weight-adjusted-waist index and increased urinary albumin excretion in adults: A population-based study

et al. 2022

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“…WWI is a new obesity index based on weight and WC, which has a good predictive ability for cardiometabolic morbidity and mortality in the Korean population ( 23 ). Li et al recently reported in a rural Chinese cohort study that the highest WWI category was significantly associated with an increased risk of HTN ( 44 ). A recent study on WWI reflecting fat and muscle mass in the opposite direction in older adults showed that WWI was positively correlated with fat mass and negatively correlated with muscle mass ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Association of the Weight-Adjusted-Waist Index With Risk of All-Cause Mortality: A 10-Year Follow-Up Study

et al. 2022

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BackgroundTo explore the relationship between weight-adjusted-waist index (WWI) and the risk of all-cause mortality in one urban community-dwelling population in China.MethodsThis is a prospective cohort study with a sample of 1,863 older adults aged 60 years or over in Beijing who completed baseline examinations in 2009–2010 and a 10-year follow-up in 2020. WWI was calculated as waist circumference (cm) divided by the square root of weight (kg). Cox regression analysis was performed to investigate the significance of the association of WWI with all-cause mortality. The area under the receiver operating characteristic (ROC) curves were used to compare the ability of each obesity index to predict mortality.ResultsDuring a median follow-up of 10.8 years (1.0 to 11.3 years), 339 deaths occurred. After adjusted for covariates, the hazard ratios (HRs) for all-cause mortality progressively increased across the tertile of WWI. Compared with the lowest WWI category (tertile1 <10.68 cm/√kg), with WWI 10.68 to 11.24cm/√kg, and≥11.25 cm/√kg, the HRs (95% confidence intervals (CIs)) for all-cause mortality were 1.58 (1.12–2.22), and 2.66 (1.80–3.92), respectively. In stratified analyses, the relationship between WWI and the risk of all-cause mortality persisted. The area under ROC for WWI was higher for all-cause mortality than BMI, WHtR, and WC.ConclusionWWI was associated with a higher risk for all-cause mortality, and the association was more robust with the highest WWI category.

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“…In 2018, Park et al proposed a new anthropometric index, the weight-adjusted-waist index (WWI), which was positively correlated with fat mass but negatively correlated with muscle mass ( 14 , 15 ). Moreover, several studies have demonstrated that WWI is associated with an elevated risk of incident hypertension and cardiovascular mortality ( 16 , 17 ). However, to our knowledge, no previous study has investigated the relationship between WWI and AAC.…”

Section: Introductionmentioning

confidence: 99%

Association between the weight-adjusted-waist index and abdominal aortic calcification in United States adults: Results from the national health and nutrition examination survey 2013–2014

Xie

Yuan

2022

Front. Cardiovasc. Med.

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BackgroundAbdominal aortic calcification (AAC) is recognized as a strong predictor of cardiovascular disease (CVD) events. This study aimed to evaluate the association between weight-adjusted-waist index (WWI) and AAC in United States adults aged ≥ 40 years.Materials and methodsData were derived from the 2013–2014 National Health and Nutrition Examination Survey (NHANES). WWI was calculated as waist circumference divided by the square root of weight. AAC scores were quantified by the Kauppila scoring system, and severe AAC was defined as an AAC score ≥ 6. Weighted multivariable regression analysis and subgroup analysis were performed to evaluate the relationship between WWI with AAC scores and severe AAC. The restricted cubic spline model was used for the dose-response analysis.ResultsA total of 2,772 participants were included with the mean WWI of 11.17 ± 0.73 cm/√kg and mean AAC score of 1.48 ± 3.27. The prevalence of severe AAC was 9.64%. WWI was positively associated with higher AAC scores [β = 0.95, 95% confidence interval (CI): 0.65–1.25, P < 0.001] and increased risk of severe AAC [odds ratio (OR) = 1.82; 95% CI: 1.20–2.75; P = 0.005]. A nearly linear relationship between the WWI and the odds of severe AAC was found after adjustment for multiple potential covariates (P for non-linear = 0.625). Subgroup analysis indicated that the association between WWI and AAC was similar in different population settings.ConclusionHigher WWI was associated with higher AAC score and increased risk of severe AAC in United States adults. Further studies are needed to confirm this relationship.

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Association of weight-adjusted-waist index with incident hypertension: The Rural Chinese Cohort Study

Cited by 69 publications

References 22 publications

The association between weight-adjusted-waist index and increased urinary albumin excretion in adults: A population-based study

The association between weight-adjusted-waist index and increased urinary albumin excretion in adults: A population-based study

Association of the Weight-Adjusted-Waist Index With Risk of All-Cause Mortality: A 10-Year Follow-Up Study

Association between the weight-adjusted-waist index and abdominal aortic calcification in United States adults: Results from the national health and nutrition examination survey 2013–2014

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