Association of well-characterized lung cancer lncRNA polymorphisms with lung cancer susceptibility and platinum-based chemotherapy response

Gong, Weiguo; Yin, Ji‐Ye; Li, Xiangping; Fang, Chao; Xiao, Di; Zhang, Wei; Zhou, Hong‐Hao; Li, Xi; Liu, Zhao‐Qian

doi:10.1007/s13277-015-4497-5

Cited by 156 publications

(134 citation statements)

References 33 publications

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“…Liu et al found a borderline significant association between rs619586 in MALAT1 and decreased hepatocellular carcinoma risk [45]. Another study carried out by Gong et al did not found any association between rs619586 genotype and lung cancer risk, but patients with rs619586 A allele had more chance of response to platinum-based chemotherapy [40]. In this study, we did not investigate the rs619586 of MALAT1 because the dbSNP database suggested it is a low-frequency SNP.…”

Section: Discussionmentioning

confidence: 87%

“…Large studies have reported that genetic polymorphisms on certain genes may affect the susceptibility of lung cancer [36, 37], sensitivity of chemo- or radiotherapy [38–40], and length of survival or prognosis [41–44]. Liu et al found a borderline significant association between rs619586 in MALAT1 and decreased hepatocellular carcinoma risk [45].…”

Section: Discussionmentioning

confidence: 99%

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A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis

Wang¹,

Xiang²,

Wu³

et al. 2017

BMC Cancer

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BackgroundRecently studies have demonstrated that the long non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) may participate in the development and progression of lung cancer. In this study, we hypothesized that genetic variant of this lncRNA may affect the prognosis of lung cancer patients.MethodsWe conducted a follow-up study for 538 patients with non–small cell lung carcinoma (NSCLC), including 140 early-staged (stage I and II) and 398 advanced staged (stage III and IV) patients. The genetic variant rs3200401 in MALAT1 was then genotyped among this population by using TaqMan assay. The association of this variant with overall survival of these patients was further analyzed.ResultsIt was shown that among the advanced lung adenoma patients, subjects carrying rs3200401 CT and CT + TT genotypes had significantly longer median survival time (MST = 29.9, 28.9 vs. 19.3 month, Long-rank P = 0.019 and 0.024, respectively) and decreased death risks [crude HR (95% CI) = 0.65 (0.43–0.98) and 0.64 (0.44–0.95), P = 0.040 and 0.025, respectively], when compared to subjects wtih the MALAT1 rs3200401 CC genotype. However, the beneficial effect of rs3200401 was not seen among early NSCLC and advanced lung squamous cell carcinoma patients. We further tested the TCGA data, and found that a higher expression of MALAT1 was associated with metastatic of advanced lung adenocarcinoma but not with lung squamous cell carcinoma.ConclusionsThe rs3200401 T allele located on the lncRNA MALAT1 was associated with a better survival for advanced lung adenocarcinoma patients, which may offer a novel prognostic biomarker for this patient subgroup. However, these results need to be validated in larger populations of lung cancer and the biological function of this variant still warrants further investigation.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-017-3151-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis

Wang¹,

Xiang²,

Wu³

et al. 2017

BMC Cancer

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“…All were case-control studies and were comprised of individuals of Asian ( n = 7) and Turkish descent ( n = 3). In addition, the studies covered diverse tumor types: gastric cancer ( n = 4) [21–24], breast cancer ( n = 3) [17–19], colorectal cancer ( n = 1) [26], lung cancer ( n = 1) [25], and esophageal squamous cell carcinoma ( n = 1) [20]. Quality of the included studies was assessed using the Newcastle Ottawa Scale, and all the studies scored a 7 or above (high-quality).…”

Section: Resultsmentioning

confidence: 99%

“…It is furthermore associated with poor prognosis, and in experimental models, it promotes tumor progression, invasion, and metastasis [12–16]. Finally, HOTAIR single nucleotide polymorphisms (SNPs) have been investigated as potential cancer susceptibility loci and linked to increased risk for human cancers, such as breast [17–19], esophageal squamous cell carcinoma [20], gastric [21–24], lung [25], and colorectal cancers [26]. However, the results remain controversial possibly due to the fact that independent studies are underpowered and biased, especially for small cohorts.…”

Section: Introductionmentioning

confidence: 99%

Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type

Wang

Huang

et al. 2016

Oncotarget

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Polymorphisms in the HOX transcript antisense intergenic RNA (HOTAIR) have been recently associated with susceptibility to different cancers. Here, a meta-analysis was performed to derive a more precise estimation of the involvement of HOTAIR polymorphisms in cancer development. Data from cases (n = 7,772) and controls (n = 9,075) were extracted from eligible studies (n = 10) identified in a comprehensive literature search conducted in PubMed, Embase, and the Web of Science databases through January 20, 2016. Overall, association between polymorphism rs920778 and increased cancer risk was significant in allele contrast (odds ratio (OR) = 1.239, 95% confidence interval (CI) = 1.032 - 1.487) and recessive models (OR = 1.614, 95% CI = 1.082 - 2.406). In subgroup analysis based on ethnicity, a significant association between polymorphism rs920778 and cancer susceptibility was observed in Asians under all models, but was most compelling under recessive (OR = 2.128, 95% CI = 1.417 - 3.197) and homozygous models (OR = 2.764, 95% CI = 2.221 - 3.440). Subgroup analysis by cancer type revealed a significant association between polymorphism rs4759314 and susceptibility to gastric cancer in allele contrast (OR = 1.262, 95% CI = 1.073 - 1.486), dominant (OR = 1.280, 95% CI = 1.060 - 1.547), and heterozygous models (OR = 1.288, 95% CI = 1.057 - 1.570). In conclusion, the results indicated that HOTAIR polymorphism rs920778 was more generally associated with cancer risk, particularly in Asians, while rs4759314 was a risk factor for gastric cancer.

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“…Growing data have revealed that SNPs in some lncRNAs are associated with chemotherapy response and tumorigenesis [22]. For example, the rs145204276 located in the promoter region of GAS5 has been reported to be an endogenous competing RNA of miR-21 [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Association Between the Deletion Allele of Ins/Del Polymorphism (Rs145204276) in the Promoter Region of GAS5 with the Risk of Atherosclerosis

Shen

Qiang

2018

Cell Physiol Biochem

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Background/Aims: LncRNA is a growth arrest-specific transcript 5 (GAS5) with tumor suppressor activities in some cancers, but its role in atherosclerosis is unclear. Methods: Bioinformatics algorithm analysis was utilized to search the target of GAS5 and miR-21, followed by luciferase assay to confirm these targets. Real-time PCR and western-blot were utilized to verify the connection among GAS5, miR-21 and Programmed cell death 4 (PDCD4). MTT assay and flow cytometry analysis were performed to explore the mechanism of GAS5 in the regulation of atherosclerosis. Results: GAS5 directly targets miR-21 and functions as a competing endogenous RNA to suppress miR-21 expression. We also observed that rs145204276 polymorphism, including INS/INS and DEL/DEL, on GAS5 promoter increased transcription activity of GAS5, but the presence of rs145204276 DEL/DEL allele significantly promoted the transcription of GAS5 promoter compared with rs145204276 INS/INS allele. PDCD4 was predicted as a direct target gene of miR-21 with a binding site on PDCD4 3’UTR. It was further confirmed by luciferase assay that miR-21 significantly reduced the luciferase activity of wild-type PDCD4 3’UTR but not that of mutant PDCD4 3’UTR. In addition, high glucose significantly inhibited the growth rate of EC genotyped as DEL/DEL or INS/ INS, and apparently promoted the apoptotic rate of either DEL/DEL or INS/INS genotype ECs. Furthermore, the effect of high glucose was stronger in the INS/INS group, while the expression of GAS5 was dramatically upregulated with the presence of GAS5 DEL/DEL, while GAS5 positively regulated PDCD4 expression via inhibiting miR-21 expression. GAS5 siRNA and miR-21 mimics significantly decreased GAS5 and PDCD4 expressions, and the inhibitory effects of GAS5 siRNA or miR-21 mimics on GAS5 and PDCD4 expressions in the INS/INS group was stronger. Moreover, GAS5 siRNA and miR-21 mimics remarkably triggered cells proliferation and suppressed cell apoptosis, and the inhibition effects of GAS5 siRNA or miR-21 mimics on either cell viability and apoptosis in the INS/INS group was stronger. In this study, we enrolled 1,306 subjects with or without atherosclerosis and found that the INS/DEL or DEL/DEL genotypes significantly decreased the risk of atherosclerosis compared with the ins/ins genotype (adjusted odds ratio: 0.74 and 0.40, respectively). Conclusion: In summary, rs145204276 was associated with the risk of atherosclerosis by affecting the proliferation and apoptosis of endothelial cells via regulating the GAS5/miR-21/PDCD4 signaling pathway.

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Association of well-characterized lung cancer lncRNA polymorphisms with lung cancer susceptibility and platinum-based chemotherapy response

Cited by 156 publications

References 33 publications

A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis

A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis

Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type

Association Between the Deletion Allele of Ins/Del Polymorphism (Rs145204276) in the Promoter Region of GAS5 with the Risk of Atherosclerosis

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