Association of white blood cell count with metabolic syndrome in patients undergoing peritoneal dialysis

Park, Sun-Hee; Chang, Tae Ik; Kim, Yon Su; Lee, Jung Eun; Kim, Hyun‐Wook; Chang, Jae Hyun; Park, Sun Young; Kim, Eun Young; Yoo, Tae‐Hyun; Han, Dae Suk; Kang, Shin Wook

doi:10.1016/j.metabol.2009.05.002

Cited by 14 publications

(10 citation statements)

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“…A significant association was noted between high BMI and WCC count. These findings may signify a role between obesity related mediators and blood cells, which has been identified previously [34][35][36]. These findings, when combined with the relationship between CTCs and WCC, may suggest a synergistic role in advanced disease.…”

Section: Plos Onesupporting

confidence: 59%

Platelet cloaking of circulating tumour cells in patients with metastatic prostate cancer: Results from ExPeCT, a randomised controlled trial

et al. 2020

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Background Circulating tumour cells (CTCs) represent a morphologically distinct subset of cancer cells, which aid the metastatic spread. The ExPeCT trial aimed to examine the effectiveness of a structured exercise programme in modulating levels of CTCs and platelet cloaking in patients with metastatic prostate cancer. Methods Participants (n = 61) were randomised into either standard care (control) or exercise arms. Whole blood was collected for all participants at baseline (T0), three months (T3) and six months (T6), and analysed for the presence of CTCs, CTC clusters and platelet cloaking. CTC data was correlated with clinico-pathological information. Results Changes in CTC number were observed within group over time, however no significant difference in CTC number was observed between groups over time. Platelet cloaking was identified in 29.5% of participants. A positive correlation between CTC number and white cell count (WCC) was observed (p = 0.0001), in addition to a positive relationship between CTC clusters and PSA levels (p = 0.0393). Conclusion The presence of platelet cloaking has been observed in this patient population for the first time, in addition to a significant correlation between CTC number and WCC. Trial registration ClincalTrials.gov identifier NCT02453139.

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Section: Plos Onesupporting

confidence: 59%

Platelet cloaking of circulating tumour cells in patients with metastatic prostate cancer: Results from ExPeCT, a randomised controlled trial

et al. 2020

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“…There was no significant correlation between components of MS and total WBC. Our findings contrast with those reported by Park et al [30], where 104 nondiabetic patients undergoing peritoneal dialysis were assessed and MS was defined using the NCEP-ATPIII criteria. …”

Section: Discussioncontrasting

confidence: 99%

Relationship between C-Reactive Protein, White Blood Cell Count and Metabolic Syndrome in Nigerians with Type 2 Diabetes Mellitus

Soyoye¹,

Ikem²,

Kolawole³

et al. 2017

JDM

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Background: Presence of metabolic syndrome (MS) in people with diabetes confers increased cardiovascular and diabetes-specific micro-and macrovascular complications. The pathogenic pathways for metabolic syndrome are still issues for discussion especially in some special groups like those with type 2 diabetes mellitus (T2DM). Recent evidences suggest that inflammation may play a key role in MS. This study assessed the relationship between MS (and its component risks) and markers of inflammation (high-sensitivity C-reactive protein {hs-CRP} and white blood cells {WBC}). Methods: A cross-sectional study involving 108 patients with T2DM. Anthropometric measurements and clinical examination were conducted. Blood sample was collected for hs-CRP, WBC, glycated haemoglobin etc. Metabolic syndrome was defined using the International Diabetes Federation criteria. Ethical approval was granted and informed consent was obtained from participants. Results: Mean age of male and female participants were 58.00 ± 7.01 years and 55.48 ± 8.35 years respectively (p = 0.092). Eighty-two (75.9%) participants had metabolic syndrome. Median values of hs-CRP and total WBC were 0.89mg/L and 5.73 x10 3 /mm 3 respectively. On correlation, hs-CRP showed statistically significant association with waist circumference (r = 0.194; p = 0.044), fasting plasma glucose (r = 0.191; p = 0.048) and serum triglycerides (p = 0.226; r = 0.019). There was no statistically significant association between WBC and the metabolic components. Conclusion: Prevalence of metabolic syndrome is high, and C-reactive protein was associated with waist circumference, fasting plasma glucose and serum triglycerides.How to cite this paper: Soyoye, D.O.,

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“…Currently, several potential routine health check-up based biomarkers, such as Hb [ 17 - 19 ], HCT [ 17 , 18 , 28 ], WBC [ 20 - 27 ], LC [ 23 , 29 ] and NGC [ 23 , 29 ], were identified for predicting MetS/its components. Correlation matrix between 11 biomarkers was illustrated in Additional file 3 : Table S3, which Shows the necessity of EFA.…”

Section: Discussionmentioning

confidence: 99%

“…Among them, BMI, SBP, DBP, TG, HDL-C and FBG were selected based on the traditional definition of MetS. The others were included according to the available results of peer studies: Hb [ 17 - 19 ], HCT [ 17 , 18 , 28 ], WBC [ 20 - 27 ], LC [ 23 , 29 ], NGC [ 23 , 29 ]. All measurements were conducted in the Center for Health Management of Shandong Provincial QianFoShan Hospital and the Health Examination Center of Shandong Provincial Hospital following same and standard procedures.…”

Section: Methodsmentioning

confidence: 99%

A routine biomarker-based risk prediction model for metabolic syndrome in urban Han Chinese population

et al. 2015

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BackgroundMany MetS related biomarkers had been discovered, which provided the possibility for building the MetS prediction model. In this paper we aimed to develop a novel routine biomarker-based risk prediction model for MetS in urban Han Chinese population.MethodsExploring Factor analysis (EFA) was firstly conducted in MetS positive 13,345 males and 3,212 females respectively for extracting synthetic latent predictors (SLPs) from 11 routine biomarkers. Then, depending on the cohort with 5 years follow-up in 1,565 subjects (male 1,020 and female 545), a Cox model for predicting 5 years MetS was built by using SLPs as predictor; Area under the ROC curves (AUC) with 10 fold cross validation was used to evaluate its power. Absolute risk (AR) and relative absolute risk (RAR) were calculated to develop a risk matrix for visualization of risk assessment.ResultsSix SLPs were extracted by EFA from 11 routine health check-up biomarkers. Each of them reflected the specific pathogenesis of MetS, with inflammatory factor (IF) contributed by WBC & LC & NGC, erythrocyte parameter factor (EPF) by Hb & HCT, blood pressure factor (BPF) by SBP & DBP, lipid metabolism factor (LMF) by TG & HDL-C, obesity condition factor (OCF) by BMI, and glucose metabolism factor (GMF) by FBG with the total contribution of 81.55% and 79.65% for males and females respectively. The proposed metabolic syndrome synthetic predictor (MSP) based predict model demonstrated good performance for predicting 5 years MetS with the AUC of 0.802 (95% CI 0.776-0.826) in males and 0.902 (95% CI 0.874-0.925) in females respectively, even after 10 fold cross validation, AUC was still enough high with 0.796 (95% CI 0.770-0.821) in males and 0.897 (95% CI 0.868-0.921) in females. More importantly, the MSP based risk matrix with a series of risk warning index provided a feasible and practical tool for visualization of risk assessment in the prediction of MetS.ConclusionsMetS could be explained by six SLPs in Chinese urban Han population. The proposed MSP based predict model demonstrated good performance for predicting 5 years MetS, and the MetS-based matrix provided a feasible and practical tool.Electronic supplementary materialThe online version of this article (doi:10.1186/s12889-015-1424-z) contains supplementary material, which is available to authorized users.

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Association of white blood cell count with metabolic syndrome in patients undergoing peritoneal dialysis

Cited by 14 publications

References 43 publications

Platelet cloaking of circulating tumour cells in patients with metastatic prostate cancer: Results from ExPeCT, a randomised controlled trial

Platelet cloaking of circulating tumour cells in patients with metastatic prostate cancer: Results from ExPeCT, a randomised controlled trial

Relationship between C-Reactive Protein, White Blood Cell Count and Metabolic Syndrome in Nigerians with Type 2 Diabetes Mellitus

A routine biomarker-based risk prediction model for metabolic syndrome in urban Han Chinese population

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