Association of White Blood Cell Count and Clustered Components of Metabolic Syndrome in Japanese Men

Nagasawa, Natsuko; Koji, Takehiko; Yatsuya, Hiroshi; Hori, Yoko; Ishikawa, Miyuki; Murata, Chiyoe; Zhang, Huiming; Wada, Keiko; Otsuka, Rei; Mabuchi, Tomoko; Kondo, Takaaki; Toyoshima, Hideaki

doi:10.1253/circj.68.892

Cited by 82 publications

(78 citation statements)

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“…Ethnic background, including genetic and environmental factors, may also affect the associations of RBC with MS, as shown in the differences in some RBC-related hematological variable levels [5] and in the prevalence of MS or its related-cardiovascular diseases [6]. Regarding other hematological variables, positive associations between WBCCs and MS have been reported [1,7,8], while associations between platelet counts and MS remain controversial [2,9]. The effects of some molecules such as proinflammatory cytokines on WBCCs are known [8].…”

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confidence: 99%

“…Regarding other hematological variables, positive associations between WBCCs and MS have been reported [1,7,8], while associations between platelet counts and MS remain controversial [2,9]. The effects of some molecules such as proinflammatory cytokines on WBCCs are known [8]. The mechanisms of the associations of RBC with MS may become clearer by the consideration of not only RBC but also various hematological variables including WBCCs and platelets.…”

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confidence: 99%

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Increased Red Blood Cells in Patients with Metabolic Syndrome

2006

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We read with great interest the recently published study by Kim et al. [1] on the relationship of red blood cell counts (RBCCs) to metabolic syndrome (MS), and its sex differences. They indicate that RBCCs are not associated with MS components in men and women. Until now, a few studies have reported a positive association of RBCCs, hemoglobin (Hb) and hematocrit with MS [2] or insulin resistance syndrome [3,4], with no mention of sex differences. These reports have provoked debate on red blood cell (RBC)-related variables as potential markers related to MS.Kim et al.[1] speculate that prior study populations may incompletely exclude patients with hematological problems, and propose reevaluation in only healthy subjects without Hb-related disorders. Thus, we investigated the associations of RBCCs and Hb with MS in a subjectively healthy Japanese population (n = 469, age = 49.4 ± 9.3 [SD], [range = 30-83] years). Subjects with Hb values from 12 to 16 g/dl and white blood cell counts (WBCCs) from 3,500 to 11,000/mm 3 were enrolled. None of the subjects were on medication, nor had apparent cardiovascular, pulmonary, hepatic, renal, malignant, infectious or hematological disorders. MS was defined by the presence of ≥3 components according to NCEP ATP III criteria with minor modifications such as obesity based on BMI values of ≥25, similar to the Kim study [1]. RBCCs and Hb were measured with an autoanalyzer. All analyses were performed using the general linear model, two-way ANOVA and multiple regression analysis, adjusted for age, sex and smoking status (non-, ex-and current smoking). P<0.05 was considered significant.The respective RBCCs and Hb levels were significantly higher in the presence of MS for each sex (p for trend<0.001), with significantly higher levels in men than women (p for trend<0 . 14.9 ± 0.73 g/dL without MS, 13.8 ± 1.11 in women with MS vs. 13.3 ± 0.77 without MS. The respective variables had a significantly increasing trend according to increases in MS components in each sex, with significantly higher levels in men than women (Table 1) Our study supports the hypothesis that RBC-related variables, RBCCs in particular, are indicators related to MS and its components (whereas the variable levels differed between sexes), contrary to the Kim study for Korean people [1]. This discrepancy may be explained by differences in study populations. In addition to ethnic differences, our study focused more on subjects without Hb-related disorders compared to those of the Kim study. Although the detailed mechanisms remain unclear on the associations of RBC with MS, insulinrelated effects on RBC have been suggested [1]. Ethnic background, including genetic and environmental factors, may also affect the associations of RBC with MS, as shown in the differences in some RBC-related hematological variable levels [5] and in the prevalence of MS or its related-cardiovascular diseases [6]. Regarding other hematological variables, positive associations between WBCCs and MS have been reported [1,7,8], while associations ...

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Increased Red Blood Cells in Patients with Metabolic Syndrome

2006

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“…Both cytokines increase hepatic lipogenesis 36,37) and elicit a systemic acutephase response 38) . Furthermore, various aspects of the acute-phase response, such as C-reactive-protein 33) , fibrinogen 23) , plasminogen activator inhibitor 1 levels 39,40) , and white blood cell count [41][42][43] , have recently been found to correlate positively with MS. Fibrinogen, on binding to its integrin receptor on the surface of leukocytes, also facilitates a chemotactic response that supposedly plays a vital role in the process of inflammation 44) . Insulin resistance is considered to be the basis of MS. Evaluated by insulin concentration and HOMA, it was related to fibrinogen in females in univariate analysis in our study.…”

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Associations of Fibrinogen with Metabolic Syndrome in Rural Chinese Population

Jia

et al. 2010

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Aim: Metabolic syndrome (MS) comprises a constellation of various metabolic abnormalities, but insulin resistance is considered the basis of the syndrome. The relationship of plasma fibrinogen with MS and insulin resistance remains inconclusive. The aim of this study was to assess whether plasma fibrinogen levels were associated with MS and insulin resistance in a rural population of China. Methods: Participants were selected using a multi-stage random-sampling method. A standardized interview was conducted by trained personnel, and "metabolic syndrome" was defined according to the Chinese Diabetes Association. Insulin resistance was assessed by fasting insulin and HOMA-IR. Associations of fibrinogen levels with components of MS and insulin resistance were determined using correlation analysis and multiple linear regression analyses.

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“…In the last decade WBCC has been found to be related with obesity and the metabolic syndrome in adults (1,2) as well as in children and adolescents (3)(4)(5) . The aim of the present work was to analyse the relationships between WBCC and obesity and features of the metabolic syndrome in a cohort of European adolescents participating in the HELENA-CSS (Healthy Lifestyle in Europe by Nutrition in Adolescence-CrossSectional Study).…”

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White blood cell count is associated with features of the metabolic syndrome in European adolescents. The HELENA Study

et al. 2013

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White blood cell count (WBCC) is used as a diagnostic tool for acute inflammatory and infectious states, but it has also been associated with other pathological conditions. In the last decade WBCC has been found to be related with obesity and the metabolic syndrome in adults (1,2) as well as in children and adolescents (3)(4)(5) . The aim of the present work was to analyse the relationships between WBCC and obesity and features of the metabolic syndrome in a cohort of European adolescents participating in the HELENA-CSS (Healthy Lifestyle in Europe by Nutrition in Adolescence-CrossSectional Study).Blood samples were collected after an overnight fast from 1,089 participants aged 12.5-17.5 years. After applying exclusion criteria (having fever and/or having received any medical treatment 24 hours prior to extraction), data were analysed from 952 adolescents (47.3% males). The sample was divided into four categories according to WBCC quartiles. Height, weight, body mass index (BMI), body fat mass and percentage, waist circumference, blood pressure (SBP and DBP), serum glucose, lipids, insulin, and indices of insulin resistance (HOMA-IR) and sensitivity (QUICKY-IS) were compared between groups by analysis of covariance (ANCOVA), adjusting for country, gender and age. Non-normally distributed variables were previously log-transformed.According to our data, adolescents with higher WBCC presented significantly higher weight (P < 0.01), BMI, body fat, waist circumference (all P < 0.001), DBP (P < 0.01), serum triglycerides (P < 0.001), total cholesterol/HDL-cholesterol and LDL/HDL-cholesterol ratios (P < 0.01), serum insulin and HOMA-IR index (both P < 0.001), and significantly lower values of serum HDL-cholesterol and QUICKY-IS index (both P < 0.001).These results support a significant positive association between WBCC and obesity and metabolic syndrome, and suggest that WBCC can be a useful marker to assess cardio-metabolic risk in European adolescents.

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Association of White Blood Cell Count and Clustered Components of Metabolic Syndrome in Japanese Men

Cited by 82 publications

References 37 publications

Increased Red Blood Cells in Patients with Metabolic Syndrome

Increased Red Blood Cells in Patients with Metabolic Syndrome

Associations of Fibrinogen with Metabolic Syndrome in Rural Chinese Population

White blood cell count is associated with features of the metabolic syndrome in European adolescents. The HELENA Study

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