Association study between growth hormone receptor (GHR) gene polymorphisms and obesity in Korean population

Yang, Seung-Ae

doi:10.12965//jer.1632844.422

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…As a transmembrane receptor for growth hormone, the GHR gene has been studied on obesity in Korean (Yang, 2016), and rs6898743 showed a significant association with obesity. In addition, this SNP also has an influence on tumor.…”

Section: Discussionmentioning

confidence: 99%

Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer

Wang

Shen

et al. 2020

Molec Gen & Gen Med

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Section: Discussionmentioning

confidence: 99%

Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer

Wang

Shen

et al. 2020

Molec Gen & Gen Med

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“…It has been showed that GHR knockout would result in dwarfism, reduced body weight and obesity [31], and many SNPs in GHR gene were associated with fat deposition in human and chickens [32,33]. In China, a great number of chicken breeds contained a sex-linked mutation in the GHR gene, which is called dw gene as mention above.…”

Section: Discussionmentioning

confidence: 99%

Integrative Analyses of mRNA Expression Profile Reveal the Involvement of IGF2BP1 in Chicken Adipogenesis

Chen

Ren

Liu

et al. 2019

IJMS

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Excessive abdominal fat deposition is an issue with general concern in broiler production, especially for Chinese native chicken breeds. A high-fat diet (HFD) can induce body weight gained and excessive fat deposition, and genes and pathways participate in fat metabolism and adipogenesis would be influenced by HFD. In order to reveal the main genes and pathways involved in chicken abdominal fat deposition, we used HFD and normal diet (ND) to feed a Chinese native chicken breed, respectively. Results showed that HFD can increase abdominal fat deposition and induce adipocyte hypertrophy. Additionally, we used RNA-sequencing to identify the differentially expressed genes (DEGs) between HFD and ND chickens in liver and abdominal fat. By analyzed these DEGs, we found that the many DEGs were enriched in fat metabolism related pathways, such as peroxisome proliferator-activated receptor (PPAR) signaling, fat digestion and absorption, extracellular matrix (ECM)-receptor interaction, and steroid hormone biosynthesis. Notably, the expression of insulin-like growth factor II mRNA binding protein 1 (IGF2BP1), which is a binding protein of IGF2 mRNA, was found to be induced in liver and abdominal fat by HFD. Ectopic expression of IGF2BP1 in chicken liver-related cell line Leghorn strain M chicken hepatoma (LMH) cell revealed that IGF2BP1 can regulate the expression of genes associated with fatty acid metabolism. In chicken preadipocytes (ICP cell line), we found that IGF2BP1 can promote adipocyte proliferation and differentiation, and the lipid droplet content would be increased by overexpression of IGF2BP1. Taken together, this study provides new insights into understanding the genes and pathways involved in abdominal fat deposition of Chinese native broiler, and IGF2BP1 is an important candidate gene for the study of fat metabolism and adipogenesis in chicken.

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“…The expression of GHR has been found to be increased in adipose tissue abdominal depots, compared to gluteal depots, suggesting an effect of growth hormone to specifically reduce abdominal adipose tissue mass [62]. Moreover, growth hormone secretion is usually impaired in obesity [63]. Furthermore, in the inflammasome pathway, inflammasomes play the role of central regulators connecting the induction and the progression of autoinflammatory disease with cellular stress from obesity-induced inflammation, metabolic distress, and other stress signals [64].…”

Section: Discussionmentioning

confidence: 99%

Methylome-Wide Association Study in Peripheral White Blood Cells Focusing on Central Obesity and Inflammation

Arpón

Milagro

Ramos-López

et al. 2019

Genes

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Epigenetic signatures such as DNA methylation may be associated with specific obesity traits in different tissues. The onset and development of some obesity-related complications are often linked to visceral fat accumulation. The aim of this study was to explore DNA methylation levels in peripheral white blood cells to identify epigenetic methylation marks associated with waist circumference (WC). DNA methylation levels were assessed using Infinium Human Methylation 450K and MethylationEPIC beadchip (Illumina) to search for putative associations with WC values of 473 participants from the Methyl Epigenome Network Association (MENA) project. Statistical analysis and Ingenuity Pathway Analysis (IPA) were employed for assessing the relationship between methylation and WC. A total of 669 CpGs were statistically associated with WC (FDR < 0.05, slope ≥ |0.1|). From these CpGs, 375 CpGs evidenced a differential methylation pattern between females with WC ≤ 88 and > 88 cm, and 95 CpGs between males with WC ≤ 102 and > 102 cm. These differentially methylated CpGs are located in genes related to inflammation and obesity according to IPA. Receiver operating characteristic (ROC) curves of the top four significant differentially methylated CpGs separated by sex discriminated individuals with presence or absence of abdominal fat. ROC curves of all the CpGs from females and one CpG from males were validated in an independent sample (n = 161). These methylation results add further insights about the relationships between obesity, adiposity-associated comorbidities, and DNA methylation where inflammation processes may be involved.

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Association study between growth hormone receptor (GHR) gene polymorphisms and obesity in Korean population

Cited by 8 publications

References 27 publications

Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer

Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer

Integrative Analyses of mRNA Expression Profile Reveal the Involvement of IGF2BP1 in Chicken Adipogenesis

Methylome-Wide Association Study in Peripheral White Blood Cells Focusing on Central Obesity and Inflammation

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