Association study of APOE, LPL and NOS3 polymorphisms with the risk of common cardio pathology in children and pregnant women

Abstract

Polymorphisms of APOE (E2/E3/E4), LPL (1595C>G) and NOS3 (-786T>C) in groups of pregnant women with and without preeclampsia, in donors, in children with hypertension, children with obesity and metabolic syndrome, and in control children were studied by PCR /RF LP analysis. Statistically significant increase of T/C genotype frequency of NOS3 in pregnant women with preeclampsia as well as in women with physiological pregnancy compared to this one in nonpregnant women of donors group was assessed (56%, 59% and 37%, respectively, F<0.03).