Association Study of Arcuate Nucleus Neuropeptide Y Neuron Receptor Gene Variation And Serum Npy Levels in Clozapine Treated Patients With Schizophrenia

Klemettilä, Jari-Pekka; Kampman, Olli; Solismaa, Anssi; Lyytikäinen, Leo-Pekka; Seppälä, Niko; Viikki, Merja; Hämäläinen, Mari; Moilanen, Eeva; Mononen, Nina; Lehtimäki, Terho; Leìnonen, Esa

doi:10.1016/j.eurpsy.2016.07.004

Cited by 8 publications

(1 citation statement)

References 70 publications

(90 reference statements)

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“…however, the well-defined hypothesis and focus only on specific genes reduces the need for a larger sample. A similar statistical approach was used in three of our earlier reports, which included the same patient sample (18,29,30). Limitations of this study include the reliance upon self-assessment of the severity of constipation and anticholinergic symptoms by each patient using the LUNSERS questionnaire.…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms Associated With Constipation and Anticholinergic Symptoms in Patients Receiving Clozapine

Solismaa¹,

Kampman²,

Lyytikäinen³

et al. 2018

J Clin Psychopharmacol

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Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms Associated With Constipation and Anticholinergic Symptoms in Patients Receiving Clozapine

Solismaa¹,

Kampman²,

Lyytikäinen³

et al. 2018

J Clin Psychopharmacol

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Genetic variants impacting metabolic outcomes among people on clozapine: a systematic review and meta-analysis

et al. 2017

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Clozapine is the gold standard medication for treatment refractory schizophrenia, but unfortunately, its use is also associated with many adverse metabolic side effects. There may be a strong genetic component to the development of these adverse effects. We undertook a systematic review to examine the evidence for genetic variation being associated with secondary metabolic outcomes in patients with schizophrenia on clozapine, under both longitudinal and cross-sectional study designs. We limited studies to those examining patients definitely taking clozapine, unlike prior reviews that have examined metabolic effects of patients taking a range of antipsychotic medications. We found associations with outcomes such as increases in BMI and metabolic syndrome for variants in genes such as LEP and HTR2C. Meta-analysis of rs381328 in HTR2C revealed that the presence of the T allele led to a 0.63 kg/m (95% CI - 1.06 to - 0.19; p = 0.005) decrease in BMI compared to the C allele. Study and population heterogeneity and lack of statistical power among reviewed articles mean that evidence is lacking to warrant prophylactic genotyping of patients commencing clozapine to predict those at increased risk of developing adverse metabolic effects. Further efforts to establish collaborative consortia, consensus around study design and replication studies in independent populations should be encouraged.

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Identification of key pathways and genes responsible for aggressive behavior

Uddin

Hussain

Rauf

et al. 2020

Computational Biology and Chemistry

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Association Study of Arcuate Nucleus Neuropeptide Y Neuron Receptor Gene Variation And Serum Npy Levels in Clozapine Treated Patients With Schizophrenia

Abstract: Serum NPY level does not seem to be a feasible biomarker of AIWG. Serum NPY level alterations are not significantly associated with the candidate gene polymorphisms studied.

Cited by 8 publications

References 70 publications

Genetic Polymorphisms Associated With Constipation and Anticholinergic Symptoms in Patients Receiving Clozapine

Genetic Polymorphisms Associated With Constipation and Anticholinergic Symptoms in Patients Receiving Clozapine

Genetic variants impacting metabolic outcomes among people on clozapine: a systematic review and meta-analysis

Identification of key pathways and genes responsible for aggressive behavior

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