2011
DOI: 10.1016/j.brainres.2010.12.072
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Association study of calcitonin gene-related polypeptide-alpha (CALCA) gene polymorphism with migraine

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Cited by 26 publications
(24 citation statements)
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“…Since it had been shown that silent SNPs also have the capacity to be functionally relevant (Duan et al, 2003;Menon et al, 2010), the 2880A N G variant, which causes an alteration from the preferred codon usage for threonine in NCOA3, was also chosen for this analysis. Burwinkel et al (2005) stated that the two rare variants were not linked to each other, which we have subsequently validated using the 2LD computer programme.…”
Section: Discussionmentioning
confidence: 99%
“…Since it had been shown that silent SNPs also have the capacity to be functionally relevant (Duan et al, 2003;Menon et al, 2010), the 2880A N G variant, which causes an alteration from the preferred codon usage for threonine in NCOA3, was also chosen for this analysis. Burwinkel et al (2005) stated that the two rare variants were not linked to each other, which we have subsequently validated using the 2LD computer programme.…”
Section: Discussionmentioning
confidence: 99%
“…RUNNING HEAD: Common Oxytocin Receptor Gene Variant 13 enhancer elements that amplify mRNA levels (Maeda et al, 2010;Menon et al, 2011;Sribudiani et al, 2011;Wang et al, 2011), methylation of CpG sites located nearby (Xue et al, 2011), and binding to functionally relevant sites outside of gene promoters (Stevens et al, 2004;Wang et al, 2005) among others (for review, see Ebstein et al, 2012).…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…The gene polymorphisms of CGRP (Insertion/Deletion (I/D) [14], rs1553005, rs145837941) and RAMP1 (rs3754701, rs7590387) [15] were studied. The polymorphism of each gene was determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP) methods.…”
Section: Genotypingmentioning
confidence: 99%
“…In addition, exposure to µ opioids such as morphine also increased CGRP in cultured dorsal root ganglion cells [12,13]. Therefore, increasing CGRP through medication overuse seems to aggravate migraines.. On the other hand, Menson et al [14] showed no significant association between the intronic 16 bp deletion in the CALCA gene and migraine. Sutherland et al [15] also reported that CALCA polymorphisms (rs3781719, rs145837941) and CGRP receptor (receptor activity-modifying protein 1: RAMP1, rs3754701, rs7590387) are not involved in the pathogenesis of migraine.…”
Section: Introductionmentioning
confidence: 98%