Association study of the PLXNA4 gene with the risk of Alzheimer’s disease

Abstract

Background:The Plexin-A 4 (PLXNA4) gene has recently been recognized as a functional candidate gene of late-onset Alzheimer's disease (LOAD). The single nucleotide polymorphism (SNP) rs13232207 of PLXNA4 gene has been reported to be associated with Alzheimer's disease (AD) in Japanese cohorts. We sought to clarify whether this novel locus gains the same effect in northern Han Chinese.Methods: To investigate the relationship between SNP rs13232207 and AD sufferers, a case-control study of unrelated individuals was conducted with a total sample size of 2,318 subjects (978 cases and 1,340 age and gender matched healthy controls) in a Northern Han Chinese population. SPSS 22.0 was applied for the statistical process.Results: No significant difference in polymorphic distribution of rs13232207 was observed on LOAD risk independently under dominant (P=0.057), additive (P=0.233) or recessive model (P=0.392). In terms of interaction with apolipoprotein E (APOE), there is also no positive interaction in dominant (P=0.438), additive (P=0.055) or recessive model (P=0.095).Conclusions: Replication of association between the PLXNA4 rs13232207 and AD in a Han ethnic group indicates that this link is not the result of chance.

Dendrobium nobileLindl alkaloid attenuates 6‐OHDA‐induced dopamine neurotoxicity

“…Many studies indicate that the pathological mechanism of DA neuron cell death in PD may be related to neuroinflammation, which indicates that the pathological interaction between DA neurons and neighboring immune cells (i.e., macrophages and lymphocytes) causes degeneration. Activated microglia plays a crucial role in the increased production of proinflammatory cytokines, such as IL-1β, TNF-α, which could lead to the loss of DA neurons [20]. At the same time, those factors are known to trigger activation of microglial, contributing to nigrostriatal pathway injury.…”

Genome-wide association and interaction studies of CSF T-tau/Aβ42 ratio in ADNI cohort

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Discovery of 8-prenylnaringenin from hop (Humulus lupulusL.) as a potent monoacylglycerol lipase inhibitor for treatments of neuroinflammation and Alzheimer's disease

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