Association study of VDR gene with rheumatoid arthritis in the French population

Vitamin D Receptor Gene Polymorphisms in Rheumatoid Arthritis

“…[21] In two reports, an association was found between BsmI polymorphism of the VDR gene and RA severity. [8][9][10] Our results agree with the results of Gomez-Vaquero et al [10] that reported no association between the VDR genotypes/alleles and the presence or absence of erosions and RF. Masi et al [22] found no relationship between RA and FokI genotype, but their results suggest that FokI polymorphism may lead to higher risk for loose bone mass.…”

“…An earlier study suggested discordance between TaqI, BsmI polymorphisms and RA but a positive correlation between FokI (F allele and F/F genotype) and RA. [9] In summary, in several studies, similar to our findings, no significant associations have been found between RA and VDR polymorphisms except for FokI polymorphism which was significantly associated with RA in a French population. [9] These results reflect that TaqI, FokI, BsmI and ApaI polymorphisms in the VDR gene may not be responsible for the primary …”

“…The results have been controversial due to ethnicities and geographic variations. [8][9][10][11][12] In addition, the age groups of the subjects and the sample sizes of these studies may account for the contradictory results. The present study evaluated for the first time the possible association of VDR polymorphisms among a group of Turkish RA patients.…”

“…There are controversial results in various reports due to ethnicities, extensive geographic variations and possibly study designs. [8][9][10][11][12] There is no data on frequencies of VDR polymorphisms in Turkish patients with RA. In this study, we aimed to investigate the association of BsmI, TaqI, and FokI polymorphisms in the VDR gene in RA patients with rheumatoid factor (RF) positivity and erosive disease of RA.…”

Dietary manipulation in musculoskeletal conditions

“…While the role of vitamin D in calcium homeostasis and maintenance of skeletal health is well recognised, it is less well known that vitamin D or its metabolites have important effects on muscle function and the immune system [105]. Receptors for 1,25(OH) 2 D (VDR) are present in more than 30 different tissues [104] while VDR polymorphisms have been found to be associated with the occurrence [106], time of onset [107], severity [108] and accelerated bone loss [109] in RA and with risk of early knee OA [110] and presence of osteophytes [111]. Evidence for the importance of vitamin D in RA and OA is assessed below.…”