Association with litter size of new polymorphisms on ESR1 and ESR2 genes in a Chinese-European pig line

Abstract

-The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size in a Chinese-European pig line. We identified five silent single nucleotide polymorphisms (SNP) in the ESR1 cDNA: c

Differential expression profiling of estrogen receptor in the ovaries of two egg duck (Anas platyrhynchos) breeds

“…These results showed similar pattern to that in geese (Kang et al, 2011) and suggest that ESR1 remained stable from newborn to the egg-laying stage and then increased during the different ovarial stages and in sexual maturity of egg ducks because it plays a pivotal role in the ovary (Drummond et al, 1999;Munoz et al, 2007). Previous studies revealed that both ESR1 and ESR2 play the role in the maintenance of ovarian function and in the process of successful reproduction (Knapczyk et al, 2008).…”

ESR1andESR2gene markers are not associated with number of piglets born alive in Italian Large White sows

“…However, a favorable effect of allele A on NBA was observed in Large White pigs (Van Rens et al, 2002;Goliasova and Wolf, 2004;Santana et al, 2006). Other studies were not able to find any association between the ESR1-PvuII polymorphism and litter size (Depuydt et al, 1999;Drögemüller et al, 2001;Linville et al, 2001;Gibson et al, 2002;Isler et al, 2002;Kmiec et al, 2002;Noguera et al, 2003;Muñoz et al, 2007).…”

“…Both genes map on Sus scrofa chromosome 1 (SSC1) and encode proteins involved in numerous physiological mechanisms directly or indirectly affecting reproduction (Muñoz et al, 2004;Distl, 2007). In particular, ESR1 is involved in the development of secondary sex traits, fertility and lactation, whereas ESR2 is essential for ovulation, maturation of the ovarian follicles and growth and development of pery-implantation embryos (Muñoz et al, 2007). The intronic PvuII recognition site polymorphism in the ESR1 gene was the first described marker gene associated with pig litter size (Rothschild et al, 1994(Rothschild et al, , 1996.…”

“…In particular one missense mutation (c.949G>A; p.317Val>Met) in exon 5 has been shown to be associated with litter size (Buske et al, 2006b), but with inconsistencies among different populations (Muñoz et al, 2004(Muñoz et al, , 2007Buske et al, 2006c;Rempel et al, 2010).…”

SNP analysis reveals estrogen receptor 1 (<i>ESR1</i>) gene variants associated with laying traits in quails

“…The role of ESR1 and ESR2 in the reproductive performance of poultry has been increasingly studied in recent years (Tang et al, 2009;Wang et al, 2012). ESR1 gene is one of the candidate genes for detecting polymorphisms associated with the reproductive and laying traits in pigs, chickens and other animals (Goliasova and Wolf, 2004;Humpolicek et al, 2007;Liu et al, 2010;Muñoz et al, 2007;Tang et al, 2009;Wang et al, 2012;Bi et al, 2005;Szreder and Zwierzchowski, 2007;Wu et al, 2014). The objectives of this study were to detect the polymorphism in five regions (exons 1, 2, 4, 8 and intron 1) of ESR gene in quail populations (the yellow-feather and chestnut-feather quails), which are bred in China and have relatively high laying performance and mature early (about 45 days), and to investigate its association with laying traits of two populations and further search the possibility of ESR1 gene being used as molecular genetic markers for laying traits.…”