Association with serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris

Abstract

Association between serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris Objective: Dilation of one or more coronary artery segments to a diameter at least 1.5 times that of a normal adjacent segment is referred to as coronary artery ectasia (CAE). Adropin is a protein involved in endothelial function and is shown to have a protective effect on the regulation of cardiac functions. Atherosclerosis and endothelial dysfunction play an important role in the development of CAE. The aim of this study was to investigate the association between serum adropin levels and isolated CAE. Methods: Patients with stable angina pectoris who underwent coronary angiography (CAG) between August 2017 and July 2018 were evaluated prospectively. A total of 92 subjects were included in the study-40 patients over 18 years old and diagnosed with isolated CAE based on CAG findings and a control group of 52 patients. Results: Serum adropin level was found to be significantly lower in the isolated CAE group compared to the control group (1019.57 pg/mL and 1151.10 pg/mL, respectively, p=0.010). The isolated CAE group also exhibited a significantly higher mean platelet volume than that in the control group (10.75 fL and 10.17 fL, respectively, p=0.011). Conclusion: Our results show that there is an association between low serum adropin level and isolated CAE.

Association of Lymphocyte-to-Monocyte Ratio, Mean Diameter of Coronary Arteries, Uric Acid with Coronary Slow Flow in Isolated Coronary Artery Ectasia

“…As the detailed pathogenesis of CAE and CSF are still uncertain, hypothesis including chronic in ammation, atherosclerosis, endothelial dysfunction and oxidative stress may have participated in the pathological processes of the two diseases [1][2][3][4][5][6][7][8][9][10][11][12]14] . Many studies focused on in ammation; however, other aspects of research were relatively few.…”

“…The rst limitation relates to its retrospective design. Some risk factors, such as the matrix metalloproteinase family, tissue inhibitors of metalloproteinases [29,30] and adropin [3] , which have a signi cant role in CAE development, couldn't be collected. Second, multivariable logistic regression analyses were performed to identify independent predictors of CSF in CAE; however, it was impossible to control for unknown confounders.…”

“…Isolated coronary artery ectasia (CAE) refers to the local diameter of a coronary artery being dilated more than 1.5 times the adjacent normal vessels and having no obvious obstruction [1][2][3][4] , with a morbidity of less than 0.32% [5] . Coronary slow ow (CSF) phenomenon is coronary angiography that has no obvious stenosis but slow forward ow perfusion [6,7] .…”

Association of the lymphocyte-to-monocyte ratio, mean diameter of coronary arteries, and uric acid level with coronary slow flow in isolated coronary artery ectasia

“…The first limitation relates to its retrospective design. Some risk factors, such as the matrix metalloproteinase family, tissue inhibitors of metalloproteinases [ 34 , 35 ] and adropin [ 2 ], which play a significant role in CAE development, could not be examined. Second, multivariable logistic regression analyses were performed to identify independent predictors of CSF in CAE; however, it was impossible to control for unknown confounders.…”

The association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross‑sectional study

“…Adropin has an important role in maintaining energy homeostasis and insulin sensitivity, which has been proved to attenuated the development of atherogenesis in animal experiment [6][7][8]. Low serum adropin level was also associated with stable angina pectoris, acute myocardial infarction and the severity of coronary atherosclerosis [9][10][11][12][13][14]. Fujie S et al also found a negative correlation between serum adropin level and carotid arterial stiffness [15].…”