Associations between anemia and insomnia or excessive daytime sleepiness in older adults

Kara, Osman; Elibol, Tayfun; Okudur, Saadet Koç; Smith, Lee; Soysal, Pınar

doi:10.1080/17843286.2022.2116895

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…However, there was no difference between the groups in terms of left ventricular wall thicknesses and diameters, suggesting that insomnia in older patients impairs myocardial functions by accelerating catabolic processes. There is compelling evidence that even short‐term reductions in sleep duration or quality may have detrimental effects on glucose regulation, inhibiting the secretion of anabolic hormones (growth hormone, 18 prolactin, 19 testosterone 20 ); changing the amount and timing of catabolic hormones glucocorticoids, 6 catecholamines 21 ; changing food regulation (food preferences, 22 timing of food consumption, 23 quantity of food); and having effects on the immune system. Zhang et al .…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, excessive daytime sleepiness (EDS), defined as the state of sleepiness during the day when the individual should be active and awake, is the second most common sleep disorder among the sleep disorders of increasing importance in recent years. EDS is associated with malnutrition, dysphagia, vitamin D deficiency, sarcopenia, falls, and anaemia 5,6 . Therefore, both insomnia and EDS are very important in geriatric practice.…”

Section: Introductionmentioning

confidence: 99%

“…EDS is associated with malnutrition, dysphagia, vitamin D deficiency, sarcopenia, falls, and anaemia. 5,6 Therefore, both insomnia and EDS are very important in geriatric practice.…”

Section: Introductionmentioning

confidence: 99%

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Effect of insomnia and excessive daytime sleepiness on cardiac functions in older adults

Fotbolcu

Soysal

2023

Psychogeriatrics

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BackgroundWe investigated the potential harmful effect in older adults of insomnia and excessive daytime sleepiness (EDS) on myocardial functions and electrophysiologic changes of the heart in terms of heart rate and QT intervals corrected for heart rate (QTc).MethodsThe study included 32 insomnia patients and 30 control subjects. An Insomnia Severity Index score of ≥15 indicated insomnia, while a score of <8 was accepted as the control group. The Epworth Sleepiness Scale was used to assess EDS, with a score of ≥11/24 points indicating EDS. Diastolic and systolic functions were evaluated in each patient by transthoracic two‐dimensional, conventional and tissue Doppler echocardiography. Heart rate and QTc were calculated for electrophysiologic changes.ResultsThe mean age was 73.2 ± 7.9 years, with 59.7% being female. Biventricular systolic and diastolic functions were impaired in the insomnia patients. The E' value for diastolic function was lower in the patients with insomnia than the controls (5.99 ± 1.59 vs. 6.88 ± 0.97, P = 0.053). Furthermore, values for the systolic function parameters Lateral‐S (7.41 ± 1.92 vs. 9.37 ± 1.83, P < 0.001), Septal‐S (6.69 ± 1.40 vs. 8.10 ± 1.30, P = 0.001), and Tricuspid‐S (12.25 ± 2.00 vs. 14.37 ± 3.13, P = 0.004) were lower for insomnia patients than for controls. In the case of EDS coexistence, the heart rate and QTc values were higher than the controls (76.47 ± 7.18 vs. 71.03 ± 10.95, P = 0.001, and 413.72 ± 28.24 vs. 394.67 ± 24.47, P = 0.015, respectively).ConclusionInsomnia is associated with impaired systolic‐diastolic functions, independent of EDS. The co‐existence of insomnia and EDS may lead to electrophysiological changes in older adults, including increased heart rate and longer QTc.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of insomnia and excessive daytime sleepiness on cardiac functions in older adults

Fotbolcu

Soysal

2023

Psychogeriatrics

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“…In this study, the main aim of which was to investigate the relationship between hypomagnesemia with insomnia and EDS, it was important to eliminate the influence of the factors mentioned above and other confounders, because factors such as diabetes mellitus, impaired blood sugar regulation, metabolic syndrome, CAD, multiple drug use, and anemia, which are excessive in hypomagnesemics, also affect sleep disorders [36,37]. Indeed, the present study demonstrated that hypomagnesemia was not associated with insomnia, but increased EDS by 1.9 times.…”

Section: Discussionmentioning

confidence: 99%

Hypomagnesemia Is Associated with Excessive Daytime Sleepiness, but Not Insomnia, in Older Adults

Tunc,

Soysal,

Pasin

et al. 2023

Nutrients

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The aim of this study was to investigate associations between serum magnesium levels with insomnia and excessive daytime sleepiness (EDS) in older adults. A total of 938 older outpatients were included in the study. Hypomagnesemia was defined as serum magnesium concentration below <1.6 mg/dL. Patients were divided into two groups: hypomagnesemia and normomagnesia (1.6–2.6 mg/dL). The Epworth Sleepiness Scale was implemented and scores of ≥11 points were categorized as EDS. The Insomnia Severity Index was implemented and scores of ≥8 indicated insomnia. The mean age was 81.1 ± 7.6 years. While the presence of EDS, hypertension, diabetes mellitus, and coronary artery disease were more common in the hypomagnesemia group than the normomagnesia group, Parkinson’s disease was less common (p < 0.05). Hemoglobin and HDL cholesterol were lower, whereas HbA1c, triglyceride, and number of drugs used were higher in the hypomagnesemia group compared to the normomagnesia group (p < 0.05). In both univariate analysis and multivariate analysis adjusted for gender, age and all confounders, there were significant associations between hypomagnesemia and EDS [odds ratio (OR):1.7; 95% confidence interval (CI): 1.6–2.6, and OR: 1.9; 95%CI: 1.2–3.3, respectively (p < 0.05)]. There was no significant relationship between hypomagnesemia and insomnia (p > 0.05). The present study identified an association between hypomagnesemia and EDS in older adults. Therefore, it may be prudent to consider hypomagnesemia when evaluating older adults with EDS and vice versa.

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“…2,3 Literature has shown that those with anemia report a lower quality of life, exclusion from social activities owing to reasons such as chronic diseases, decreased functional capacity, cognitive impairments, gait and balance problems, malnutrition, muscle weakness and the other geriatric syndromes. 4,5 Moreover, it is well known that anemia increases the severity of all these conditions in older adults or facilitates their occurrence.…”

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confidence: 99%

Comment on “association between hemoglobin level and cognitive profile in old adults: A cross‐sectional survey”

Soysal

Kara

2023

Int J Geriat Psychiatry

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Associations between anemia and insomnia or excessive daytime sleepiness in older adults

Cited by 4 publications

References 23 publications

Effect of insomnia and excessive daytime sleepiness on cardiac functions in older adults

Effect of insomnia and excessive daytime sleepiness on cardiac functions in older adults

Hypomagnesemia Is Associated with Excessive Daytime Sleepiness, but Not Insomnia, in Older Adults

Comment on “association between hemoglobin level and cognitive profile in old adults: A cross‐sectional survey”

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