Background COVID‐19 due to SARS‐CoV‐2 was first described in the city of Wuhan in China and spread around the world turning into a pandemic. COVID‐19 can affect different organ systems, including the oral mucosa. Aims Although cutaneous involvement has been defined in association with COVID‐19, the number of case reports about mucosal involvement by SARS‐CoV‐2 is limited. Hereby, we report a case of hemorrhagic necrosis on the lip in a patient with paroxysmal nocturnal hemoglobinuria (PNH) and COVID‐19 infection and briefly discuss its possible mechanism. Patients The clinical features and causes of hemorrhagic necrosis on the lip in a woman are presented. Results In our patient, we think that PNH‐associated dermal micro‐occlusions caused extensive painful necrosis of the lip. Additionally, COVID‐19‐induced endothelial damage helped to develop exaggerated hemorrhagic necrosis. Conclusion This current case presentation will contribute to the literature as another case with COVID‐19 triggering mucosal involvement.

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Objective: Chronic Neutrophilic Leukemia (CNL) is a rarely seen myeloproliferative neoplasia (MPN) in which the BCR-ABL1 gene mutation is negative, and is characterized by persistent neutrophilic proliferation in the bloodstream and granulocytic hyperplasia in the bone marrow. CNL is usually diagnosed incidentally in asymptomatic individuals with persistent neutrophilic leukocytosis. When genetically examined, BCR-ABL1 fusion gene, JAK-2 V617F, and exon12 mutations, CALR mutations, PDGFRA-B, FGRF1 mutations are all not detected, while CSF3R mutation is observed in most of the cases. The WHO-2016 classification determined the presence of CSF3R T618I and other activating CSF3R mutations as diagnostic criteria. While the prognosis is poor in CNL cases with the CSF3R T618I mutation, it is more moderate in the presence of other CSF3R mutations. The average life expectancy is 21-30 months, and 5-year survival rates are around 28%. Although no treatment modality provides an average survival advantage other than hematopoietic stem cell transplantation (HSCT), there is no accepted 'standard of care' consensus. HSCT procedures performed in CNL cases are limited in the literature. Case: In this study, we presented two cases of CNL who were successfully treated with allogeneic stem cell transplantation and cured.

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ÖzetAmaç: Obezite diğer hastalıkları da beraberinde getiren önemli bir sağlık sorunudur. Çalışmamızda tip 2 diabetes mellitus (DM) tanısı olan normal, fazla kilolu ve obez olguları ayırıp, obezitenin inflamatuvar bir belirteç olan Hs-CRP üzerine etkisini incelemeyi amaçladık. Yöntem:Çalışma Abs tractAim: Obesity is a major health problem causing major illnesses and diseases. In this study, we aimed to differentiate type 2 diabetic normal, overweight and obese people to investigate the relationship of obesity with C-reactive protein (Hs-CRP), an inflammatory identifier. Methods:The study was conducted on a total of 129 patients (64 female, 65 male) with type 2 diabetes mellitus between May 2010 and September 2010. Study consisted of three groups, classified according to body mass; 16 normal weight, 55 overweight and 58 obese patient. Hs-CRP levels were measured by immunoassay chemiluminescence. All data were statistically analyzed. Results:A significant difference in hs-CRP levels was determined between the groups (p<0.05). Hs-CRP levels in subjects with normal body weight were found to be significantly lower than in obese ones (p<0.05). There was no significant difference in age, cholesterol parameters and HbA1c between the groups. No significant difference was observed in BMI between genders (p<0.05). Based on BMI, the rate of obese women was considerably higher than the rate of overweight and normal women (p<0.05). Similarly, the rate of overweight and normal men was significantly higher than the rate of obese men (p<0.05). Conclusion: Hs-CRP levels in people with normal body weight were confirmed to be significantly lower than those in obese people (p<0.05). Hs-CRP levels were observed to be increased with weight gain. GirişGünümüz insanının en önemli sağlık sorunlarından birihaline gelen obezite, dünyadaki hızlı prevalans artışı ve beraberinde getirdiği hastalık riskleri nedeniyle güncelliğini korumakta olan bir konudur. Besin maddelerinin çeşitliliği ve ulaşılabilirliğinin daha kolay hale gelmesiyle birlikte fazla