Associations between APOE-, COMT Val108/158Met- and BDNF Val66Met polymorphisms and variations in depressive and anxiety symptoms, sense of coherence and vital exhaustion in the real-life setting of mandatory basic military training

Alexopoulos, Panagiotis; Papanastasiou, Anastasios D.; Economou, Polychronis; Beis, Pavlos; Niforas, Michail; Dassios, Theodore; Kormpaki, Aggeliki; Zarkadis, Ioannis K.; Reichel, Martin; Kornhuber, Johannes; Perneczky, Robert; Gourzis, Philippos

doi:10.1007/s00702-020-02280-1

Cited by 4 publications

(2 citation statements)

References 62 publications

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“…Among military veterans, ε4 allele carriage correlates with PTSD symptom severity [66,67]. Opposite results were obtained in an assessment of subclinical symptoms of anxiety during a 19-day military training; APOE ε4 noncarriers showed significant changes in anxiety and depressive symptoms and in their sense of coherence, unlike ε4 carriers [68]. It is possible that an APOE genotype interacts differently with acute and chronic stress.…”

Section: Introductionmentioning

confidence: 97%

Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis

Mikhailova,

Ivanoshchuk,

Orlov

et al. 2023

Genes

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Background: A socioeconomic crisis in Russia lasted from 1991 to 1998 and was accompanied by a sharp drop in the birth rate. The main factor that influenced the refusal to have children during this period is thought to be prolonged social stress. Methods: comparing frequencies of common gene variants associated with stress-induced diseases among generations born before, after, and during this crisis may show which genes may be preferred under the pressure of natural selection during periods of increased social stress in urban populations. Results: In the “crisis” group, a statistically significant difference from the other two groups was found in rs6557168 frequency (p = 0.001); rs4522666 was not in the Hardy–Weinberg equilibrium in this group, although its frequency did not show a significant difference from the other groups (p = 0.118). Frequencies of VNTRs in SLC6A3 and MAOA as well as common variants rs17689918 in CRHR1, rs1360780 in FKBP5, rs53576 in OXTR, rs12720071 and rs806377 in CNR1, rs4311 in ACE, rs1800497 in ANKK1, and rs7412 and rs429358 in APOE did not differ among the groups. Conclusions: a generation born during a period of prolonged destructive events may differ from the rest of the gene pool of the population in some variants associated with personality traits or stress-related disorders.

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Section: Introductionmentioning

confidence: 97%

Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis

Mikhailova,

Ivanoshchuk,

Orlov

et al. 2023

Genes

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“…In addition, the symptoms experienced may limit participation in health-promoting behaviors. Military personnel of different countries, of both genders, of different religions, of different nationalities and races, have increased risks of psychological disorders, although there is variability in their manifestations [4][5][6][7][8][9][10]. In Ukraine, such studies have increased in connection with the psychological consequences of the presence of military personnel in the combat zone, starting from 2014.…”

Section: Introductionmentioning

confidence: 99%

Complex psychophysiological approach to the diagnostic of anxiety and depressive states for military personnel

Babak,

Petrachkov,

Biloshitskiy

2023

Fiziol Zh

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The specifics of military activity under certain environmental conditions can become an indicator of hidden anxiety disorders and depressive states of the personality. Timely detection of those states in military personnel is very important for providing them with appropriate professional assistance. In Ukraine today, given the military realities, this topic is quite relevant. The presence of anxiety and depression was studied in 48 male servicemen aged 19-22 years. Psychophysiological and psychological methods were used: the Hospital Anxiety and Depression Scale and the Hamilton Anxiety Rating Scale. To assess the adaptation potential, the method of determining the index of functional changes was used, which takes into account both functional reserves and the degree of tension of homeostasis regulatory mechanisms. The predominance of a certain department of the autonomic nervous system was determined by Kerdo’s Vegetative index. Ruffier functional test provides an opportunity to evaluate the functional capabilities of the cardiovascular system, and the Robinson index characterizes systolic work of the heart. The projective “House-Tree-Person” test provides an opportunity to find out the self-perception and stereotyped reactions of a person. To identify the relationship between the methods, the Pearson correlation coefficient was calculated. Correlations between psychophysiological and psychological research methods of anxiety and depression presence have been determined. It can be argued that the use of psychological projective methods in combination with psychophysiological research provides extensive information about the presence of conscious and unconscious symptom complexes and about the probability of the presence of such personality traits as insecurity, anxiety, aggressiveness, depression, difficulties in self-expression, etc. Early detection of these traits may prevent impairments of military activities in critical periods.

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Association of Gastrointestinal Symptoms with Depression and Anxiety in Recruits: A Validation Cross-Sectional Study

Liu,

et al. 2024

Adv Ther

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Associations between APOE-, COMT Val108/158Met- and BDNF Val66Met polymorphisms and variations in depressive and anxiety symptoms, sense of coherence and vital exhaustion in the real-life setting of mandatory basic military training

Cited by 4 publications

References 62 publications

Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis

Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis

Complex psychophysiological approach to the diagnostic of anxiety and depressive states for military personnel

Association of Gastrointestinal Symptoms with Depression and Anxiety in Recruits: A Validation Cross-Sectional Study

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