Associations between Body Mass Index and Visual Impairment of School Students in Central China

Yang, Fang; Yang, Chongming; Liu, Yuzhong; Peng, Shuzhen; Liu, Bei; Gao, Xudong; Tan, Xiaodong

doi:10.3390/ijerph13101024

Cited by 24 publications

(21 citation statements)

References 46 publications

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“…Although disease duration and HbA1C were not predictive of BCVA in type 2 diabetics with or without BRB leakage, baseline BMI was negatively correlated with BCVA at 12 and 24 months only in the group of type 2 diabetics with established BRB leakage, which is another subtle difference that we noted between the 2 groups. A previous study in Central China showed that overweight children are more likely to have visual impairment compared to normal weight children . Although that study agrees partially with our findings, we could not find any recent study in the literature that could explain why this relationship was only observed in type 2 diabetics with established BRB leakage.…”

Section: Discussionsupporting

confidence: 86%

Occipital blood‐brain barrier permeability is an independent predictor of visual outcome in type 2 diabetes, irrespective of the retinal barrier: A longitudinal study

Abuhaiba

Cordeiro

Amorim

et al. 2018

J Neuroendocrinology

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Blood‐brain barrier (BBB) permeability in type 2 diabetic patients has been previously shown to be altered in certain brain regions such as the basal ganglia and the hippocampus. Because of the histological and functional similarities between the BBB) and the blood‐retinal barrier (BRB), we aimed to investigate how the permeability of both barriers predicts visual outcome. We included 2 control groups (acute unilateral stroke patients, n = 9; type 2 diabetics without BRB leakage n = 10) and a case study group of type 2 diabetics with established BRB leakage (n = 17). We evaluated sex, age, disease duration, metabolic impairment, retinopathy grade and BBB permeability as predictors of visual acuity at baseline, 12 and 24 months in the type 2 diabetics without BRB leakage group and the case study group. We have also explored differences in BBB permeability in the occipital lobe and frontal lobe in the 3 different groups. Ktrans (volume transfer coefficient) and Vp (fractional plasma volume) were estimated. The BBB permeability parameter Vp was higher in the case study group compared to the unaffected hemisphere of the stroke patient control group, suggesting vascular dynamics were changed in the occipital lobe of type 2 diabetics with established BRB leakage. These patients showed a significant correlation between glycated hemoglobin (HbA1C) levels and occipital and frontal Ktrans. We report for the first time that occipital BBB permeability is an independent predictor of visual acuity at baseline, as well as at 12 and 24 months, in type 2 diabetics with established BRB leakage. Our results suggest that occipital BBB permeability might be an independent biomarker for visual impairment in patients with established BRB leakage.

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Section: Discussionsupporting

confidence: 86%

Occipital blood‐brain barrier permeability is an independent predictor of visual outcome in type 2 diabetes, irrespective of the retinal barrier: A longitudinal study

Abuhaiba

Cordeiro

Amorim

et al. 2018

J Neuroendocrinology

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“…Findings from the present study support previous literature showing that obesity is negatively associated with ocular health including an increased risk of cataracts [7][8][9][10] and trouble seeing (eg, visual impairment [11][12] and poor visual acuity 13 ). For example, a US study including 87 682 women and 45 549 men followed for at least 10 years found that obesity was a risk factor for any type of cataract (relative risk = 1.36) after adjusting for several potential confounders (eg, age, smoking, and lutein/zeaxanthin intake), and that this association was the strongest for posterior subcapsular cataract.…”

Section: Interpretation Of the Findingssupporting

confidence: 90%

“…This increasing trend is of concern as obesity is an important risk factor for many chronic conditions such as cardiovascular disease, 2 diabetes, 3 cancer, 4 osteoarthritis, 5 and depression. 6 Importantly, in addition to the commonly recognized health outcomes associated with obesity, there is an increasing body of literature suggesting that overweight and obesity are associated with poor ocular health (eg, cataract, [7][8][9][10] visual impairment, 11,12 and poor visual acuity 13 ). For example, an Australian study of 3654 participants aged ≥49 years identified obesity as a risk factor for both cortical (odds ratio…”

Section: Introductionmentioning

confidence: 99%

Associations between obesity and ocular health in Spanish adults

et al. 2020

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Introduction: Obesity has been associated with poor vascular health, but not in a Spanish population. Therefore, the study aimed to investigate associations between obesity and cataract, wearing glasses or contact lenses, and trouble seeing in a large representative sample of the Spanish adult population. Methods: Cross-sectional data from the Spanish National Health Survey 2017 were analyzed. Body mass index (BMI) was calculated and obesity was defined as BMI ≥ 30 kg/m 2. Ocular health included three dichotomous variables (presence vs absence): self-reported cataract, wearing glasses or contact lenses, and trouble seeing. Multivariable logistic regressions were used to assess associations between obesity (independent variable) and ocular health outcomes (dependent variables). Covariates included in the analysis were sex, age, marital status, education, smoking, alcohol, and diabetes. Results: A total of 23 089 participants were included (54.1% female; mean [SD] age = 53.4 [18.9] years). After adjusting for sex, age, marital status, education, smoking, alcohol, diabetes, and wearing glasses or contact lenses (for the trouble seeing analysis only), obesity was found to be a risk factor for cataract (odds ratio [OR] = 1.22; 95% confidence interval [CI], 1.09-1.37) and trouble seeing (OR = 1.20; 95% CI, 1.09-1.32) but not for wearing glasses or contact lenses (OR = 0.99; 95% CI, 0.91-1.08). These findings were corroborated in participants ≥64 years. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Threshold effect analysis was conducted using Empower (R) (www.empowerstats.com, X & Y Solutions, Boston, MA). 24 P < 0.05 was the threshold for statistical significance. GraphPad Prism (6.01, San Diego, CA) and SPSS for Windows (13.0, Chicago, IL) were used for all statistical analyses and graphics.…”

Section: Discussionmentioning

confidence: 99%

“…Threshold effect analysis was conducted using Empower (R) (http://www.empowerstats.com, X & Y Solutions, Boston, MA) . P < 0.05 was the threshold for statistical significance.…”

Section: Methodsmentioning

confidence: 99%

Spatiotemporal variations of magnetic susceptibility in the deep gray matter nuclei from 1 month to 6 years: A quantitative susceptibility mapping study

Ning

Liu

et al. 2018

Magnetic Resonance Imaging

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Background Quantitative susceptibility mapping (QSM) is emerging as a technique that quantifies the paramagnetic nonheme iron in brain tissue. Brain iron quantification during early development provides insights into the underlying mechanism of brain maturation. Purpose To quantify the spatiotemporal variations of brain iron‐related magnetic susceptibility in deep gray matter nuclei during early development by using QSM. Study Type Retrospective. Subjects Eighty‐seven infants and children aged 1 month to 6 years. Field Strength/Sequence Enhanced T2*‐weighted angiography using a 3D gradient‐echo sequence at 3.0T. Assessment QSM was calculated by modified sophisticated harmonic artifact reduction for phase data and sparse linear equations and sparse least squares‐based algorithm. Means of susceptibility in deep gray matter nuclei (caudate nucleus, putamen, globus pallidus, thalamus) relative to that in splenium of corpus callosum were measured. Statistical Tests Relationships of mean susceptibility with age and referenced iron concentration were tested by Pearson correlation. Differences of mean susceptibility between the selected nuclei in each age group were compared by one‐way analysis of variance (ANOVA) and Fisher's Linear Significant Difference (LSD) test. Results Positive correlations of susceptibility with both referenced iron concentration and age were found (P < 0.0001); particularly, globus pallidus showed the highest correlation with age (correlation coefficient, 0.882; slope, 1.203; P < 0.001) and greatest susceptibility (P < 0.05) among the selected nuclei. Data Conclusion QSM allows the feasible quantification of iron deposition in deep gray matter nuclei in infants and young children, which exhibited gradual accumulation at different speeds. The fastest and highest iron accumulation was observed in the globus pallidus with increasing age during early development. Level of Evidence: 4 Technical Efficacy:Stage 2 J. Magn. Reson. Imaging 2018.

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Associations between Body Mass Index and Visual Impairment of School Students in Central China

Cited by 24 publications

References 46 publications

Occipital blood‐brain barrier permeability is an independent predictor of visual outcome in type 2 diabetes, irrespective of the retinal barrier: A longitudinal study

Occipital blood‐brain barrier permeability is an independent predictor of visual outcome in type 2 diabetes, irrespective of the retinal barrier: A longitudinal study

Associations between obesity and ocular health in Spanish adults

Spatiotemporal variations of magnetic susceptibility in the deep gray matter nuclei from 1 month to 6 years: A quantitative susceptibility mapping study

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