Associations between Cigarette Smoking and Each of 21 Types of Cancer: A Multi-Site Case-Control Study

Siemiatycki, Jack; Krewski, Daniel; Franco, Eduardo L.; Kaiserman, Murray

doi:10.1093/ije/24.3.504

Cited by 131 publications

(68 citation statements)

References 32 publications

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“…Out of the 11 reporting an increased risk (Hammond and Horn, 1958;Paffenbarger Jr et al, 1977;Williams and Horm, 1977;Matthews et al, 1984;McLaughlin et al, 1995;Siemiatycki et al, 1995;Adami et al, 1998;Stagnaro et al, 2001;Briggs et al, 2002;Glaser et al, 2004;Nieters et al, 2005), three presented significant results (McLaughlin et al, 1995;Briggs et al, 2002;Nieters et al, 2005), among which one is part of our research (Nieters et al, 2005). These studies were characterised by small sample size, 10 of the 15 studies being based on less than 200 case -control pairs.…”

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confidence: 84%

“…Sixteen epidemiological studies have investigated the effect of tobacco smoking on HL (Hammond and Horn, 1958;Newell et al, 1973;Paffenbarger Jr et al, 1977;Williams and Horm, 1977;Abramson et al, 1978;Matthews et al, 1984;Bernard et al, 1987;McLaughlin et al, 1995;Siemiatycki et al, 1995;Adami et al, 1998;Miligi et al, 1999;Stagnaro et al, 2001;Briggs et al, 2002;Gallus et al, 2004;Glaser et al, 2004;Nieters et al, 2005). Out of the 11 reporting an increased risk (Hammond and Horn, 1958;Paffenbarger Jr et al, 1977;Williams and Horm, 1977;Matthews et al, 1984;McLaughlin et al, 1995;Siemiatycki et al, 1995;Adami et al, 1998;Stagnaro et al, 2001;Briggs et al, 2002;Glaser et al, 2004;Nieters et al, 2005), three presented significant results (McLaughlin et al, 1995;Briggs et al, 2002;Nieters et al, 2005), among which one is part of our research (Nieters et al, 2005).…”

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confidence: 99%

“…Although an association between smoking and HL has been reported or suggested by several studies (Hammond and Horn, 1958;Paffenbarger Jr et al, 1977;Williams and Horm, 1977;Matthews et al, 1984;McLaughlin et al, 1995;Siemiatycki et al, 1995;Adami et al, 1998;Stagnaro et al, 2001;Briggs et al, 2002;Glaser et al, 2004), HL has not been regarded as a smoking-related cancer (Jaffe et al, 2001;IARC, 2002). Out of the five previous investigations stratifying the analyses by age or restricting inclusion to subjects over 35 years old, two American studies reported significant increased risks of HL owing to smoking (McLaughlin et al, 1995;Briggs et al, 2002).…”

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confidence: 99%

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Tobacco smoking, alcohol drinking and Hodgkin's lymphoma: a European multi-centre case–control study (EPILYMPH)

et al. 2006

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We analysed the effects of tobacco and alcohol in the aetiology of Hodgkin's lymphoma (HL), based on 340 cases and 2465 controls enrolled in Spain, France, Italy, Germany, Ireland and Czech Republic, between 1998 and2004. Current smokers showed a significantly increased odds ratio (OR) of HL of 1.39 (95% confidence interval (CI) ¼ 1.04 -1.87). Analyses were also conducted separately for subjects younger than 35 years (179 cases) and for older subjects (161 cases). For subjects below age 35, no association was observed between tobacco and HL, whereas for older subjects, ever-smokers experienced a doubled risk of HL as compared to never smokers and the OR of HL for current smoking was 2.35 (95% CI ¼ 1.52 -3.61), with suggestion of a doseresponse relationship. A protective effect of alcohol was observed in both age groups. The OR for ever-regular drinking was 0.58 (95% CI ¼ 0.38 -0.89) for younger subjects and 0.50 (95% CI ¼ 0.34 -0.74) for older subjects. There was no evidence of interaction between tobacco and alcohol. Our results are consistent with previous studies, suggesting a protective effect of alcohol on HL. An effect of tobacco was suggested for HL occurring in middle and late age, although this finding might have occurred by chance.

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confidence: 84%

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confidence: 99%

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Tobacco smoking, alcohol drinking and Hodgkin's lymphoma: a European multi-centre case–control study (EPILYMPH)

et al. 2006

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“…The majority of lung cancer patients are smokers (4). Cigarette smoke is known to increase the carcinogen DNA-adduct levels, which in turn form aggressive tumors by mutating and thus inactivating tumor suppressor genes, such as TP53, and thereby decrease the survival rates of patients with NSCLC (5,6).…”

Section: Introductionmentioning

confidence: 99%

Xenobiotic/drug metabolizing enzyme and TP53 polymorphisms and clinical outcome in advanced nonsmall cell lung cancer patients

et al. 2017

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Background/aim: The association between polymorphisms of xenobiotic/drug metabolizing enzymes and TP53 and response to chemotherapy and survival of patients with nonsmall cell lung cancer (NSCLC) are limited and inconclusive. In this study, CYP2E1*5B, CYP2E1*6, CYP2E1*7B, GSTO1 (A140D), and TP53 (Arg72Pro) polymorphisms and response to platinum-based chemotherapy and survival in 137 advanced stage NSCLC patients were investigated.Materials and methods: Genetic polymorphism analyses were determined by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). Results:The patients with TP53 Pro/Pro variant were more likely to be resistant to chemotherapy than those with Arg/Arg variants with marginal significance (P = 0.066). We also analyzed these gene variants in combination with CYP1A1 (Ile462Val), CYP1B1 (Asn453Ser), GSTM1, GSTP1 exon 5 (Ile105Val), and GSTP1 exon 6 (Ala114Val) and GSTT1 polymorphic genes that we have previously genotyped in the same patients (Ada et al., Neoplasma, 57, 512-527, 2010). The multivariate analysis revealed that adjusted hazard ratio (HR) of death of the combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile462Val, Val462Val) increased significantly as compared to wild-type genotypes (HR,

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“…3,4,[9][10][11][12] Increased risks were observed also for other NHL subtypes, including low-grade 6 or high-grade NHL. 5,6 However, other prospective 4,13 and case-controls studies [14][15][16][17][18][19][20][21][22] found no consistent association between tobacco and NHL risk.…”

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confidence: 99%

Smoking and non‐Hodgkin lymphoma: Case‐control study in Italy

Talamini

Polesel

Montella

et al. 2005

Intl Journal of Cancer

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Tobacco smoking is a well-documented risk factor for several cancers, but the role of cigarette smoking in the etiology of non-Hodgkin lymphoma (NHL) is inadequately understood. Hepatitis C virus (HCV) has been associated with NHL, but the interaction between HCV and smoking habits has not yet been studied. Between 1999 and 2002, we conducted a case-control study on the association of HCV, smoking habits and NHL in 2 areas of northern and southern Italy. Cases were 225 consecutive patients (median age, 59 years) with a new diagnosis of NHL that were admitted to reference and general hospitals. Controls were 504 patients (median age, 63 years) admitted to the same hospitals as cases, for a wide spectrum of acute, nonneoplastic, nonimmune-, nor tobacco-related conditions. Current, heavy smokers (!20 cigarettes/day) had an odds ratio (OR) of NHL of 2.10 (95% confidence interval, CI: 1.07-4.12) compared to never smokers. The association between smoking and NHL was consistent across strata of sex and age. Compared to never smokers, current smokers of !20 cigarettes/day had ORs of 1.14 (95% CI: 0.37-3.56) for B-cell-low-grade, 2.10 (95% CI: 0.94-4.67) for B-cell-intermediate and high-grade, and 25.84 (95% CI: 1.95-342.17) for T-cell NHL. The effect of tobacco smoking and HCV were independent on the relative risk, leading a 4-fold elevated risk in current smokers HCV positive subjects. Tobacco smoking and hepatitis C virus (HCV) have been associated to non-Hodgkin lymphoma (NHL), but the interaction between HCV and smoking habits has not yet been studied. Our study confirms that tobacco is related to NHL, and reports on the combined effect of tobacco smoking and HCV. Infection acted together according to a multiplicative model, leading to a 4-fold elevated risk in current smokers HCV positive subjects. ' 2005 Wiley-Liss, Inc.

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Associations between Cigarette Smoking and Each of 21 Types of Cancer: A Multi-Site Case-Control Study

Cited by 131 publications

References 32 publications

Tobacco smoking, alcohol drinking and Hodgkin's lymphoma: a European multi-centre case–control study (EPILYMPH)

Tobacco smoking, alcohol drinking and Hodgkin's lymphoma: a European multi-centre case–control study (EPILYMPH)

Xenobiotic/drug metabolizing enzyme and TP53 polymorphisms and clinical outcome in advanced nonsmall cell lung cancer patients

Smoking and non‐Hodgkin lymphoma: Case‐control study in Italy

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