Associations between Dietary Nutrient Intakes and Hepatic Lipid Contents in NAFLD Patients Quantified by 1H-MRS and Dual-Echo MRI

Cheng, Yi-Peng; Zhang, Kewei; Yang, Chen; Li, Yanchuan; Li, Yuzheng; Fu, Kexue; Feng, Rennan

doi:10.3390/nu8090527

Cited by 46 publications

(51 citation statements)

References 39 publications

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“…A case-control study conducted in 36 Chinese participants also suggested that there is , and BMI e Adjusted for age, sex (only for all participants), BMI, type 2 diabetes, hypertension, hyperlipidaemia, physical activity, educational level, household income, smoking status, drinking status, employment status, energy intake (kcal/d), total carbohydrate intake (g/d), total fat intake (g/d), sweet foods intake (g/d), red meat intake (g/d), white meat intake (g/d), DHA + EPA intake (g/d), and family history of CVD, hypertension, and diabetes no difference in DF intake between NAFLD patients and healthy controls [22]. The mean (standard deviation) intake of DF in cases and control were 21.45 (6.21) and 19.67 (5.47) grams per day [22]. Another study which included 140 Iranians explored the associations between DF intake and NAFLD with adjustments of energy intake, age, and sex [12].…”

Section: Discussionmentioning

confidence: 99%

Insoluble dietary fibre intake is associated with lower prevalence of newly-diagnosed non-alcoholic fatty liver disease in Chinese men: a large population-based cross-sectional study

Yang

Zhang

et al. 2020

Nutr Metab (Lond)

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Background: The health benefits of dietary fibre (DF) intake on non-alcoholic fatty liver disease (NAFLD) are controversial. Thus, this large cross-sectional study aimed to determine the associations between DF intake and the prevalence of newly-diagnosed NAFLD in a large general population. Methods: A total of 23,529 participants were enrolled in the analyses. Newly-diagnosed NAFLD was diagnosed according to liver ultrasonography and history of alcohol intake. DF intake was assessed using a validated selfadministered food frequency questionnaire. Logistic regression analysis was applied to estimate the associations between DF intake and NAFLD. Results: In total, 18.81% (n = 4426) of the participants were newly diagnosed with NAFLD. Compared with the participants in the lowest quartile of DF intake, the ORs (95% CI) for the participants in the highest quartile were 0.81 (0.67, 0.97), 0.78 (0.62, 0.99), and 0.85 (0.62, 1.17) for all participants, men, and women, respectively. Compared with the participants in the lowest quartile of insoluble DF intake, the ORs (95% CI) for the participants in the highest quartile were 0.70 (0.58, 0.85), 0.60 (0.47, 0.76), and 0.95 (0.68, 1.32) in all participants, men, and women, respectively. No association was observed between soluble DF intake and NAFLD. DF from whole grain, soy foods, vegetables, and nuts but not fruits were negatively associated with NAFLD. Conclusions: A higher intake of insoluble DF is associated with lower prevalence of newly-diagnosed NAFLD in men. Moreover, intake DF from whole grain, soy foods, vegetables, and nuts, but not fruits have favorable effect on the prevalence of newly diagnosed NAFLD. Further cohort studies and randomized controlled trials are needed to validate this finding.

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Section: Discussionmentioning

confidence: 99%

Insoluble dietary fibre intake is associated with lower prevalence of newly-diagnosed non-alcoholic fatty liver disease in Chinese men: a large population-based cross-sectional study

Yang

Zhang

et al. 2020

Nutr Metab (Lond)

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“…Regarding the protein content of the diet, several studies have reported a significantly higher protein intake in patients with NAFLD compared to controls [ 10 , 39 , 40 , 41 ], while other studies found no difference [ 11 , 45 ]. In 2016, Kobayashi, et al [ 46 ] compared the dietary intake of Japanese patients with NAFLD and T2D.…”

Section: Observations Of Dietary Composition and Patterns In Nafldmentioning

confidence: 99%

“…In a study from Japan, patients with NAFLD had a lower vegetable intake and a higher consumption of fruits and sweets compared to T2D patients [ 46 ]. In 2016, Cheng and colleagues [ 45 ] assessed the relationship between dietary intake and hepatic lipid content in NAFLD, and showed that fiber intake was inversely associated with hepatic fat fraction and intrahepatic lipid.…”

Section: Observations Of Dietary Composition and Patterns In Nafldmentioning

confidence: 99%

Dietary Composition Independent of Weight Loss in the Management of Non-Alcoholic Fatty Liver Disease

2017

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Poor dietary composition is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). The majority of NAFLD patients follow diets with overconsumption of simple carbohydrates, total and saturated fat, with reduced intake of dietary fiber and omega-3 rich foods. Although lifestyle modifications including weight loss and exercise remain the keystone of NAFLD management, modifying dietary composition with or without a calorie-restricted diet may also be a feasible and sustainable strategy for NAFLD treatment. In the present review article, we highlight the potential therapeutic role of a “high quality healthy diet” to improve hepatic steatosis and metabolic dysfunction in patients with NAFLD, independent of caloric restriction and weight loss. We provide a literature review evaluating the evidence behind dietary components including fiber-, meat- and omega-3-rich diets and, pending further evidence, we concur with the EASL-EASD-EASO Clinical Guidelines recommendation of the Mediterranean diet as the diet of choice in these patients.

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“…In these circumstances, a nutritional supplement designed to address the specific metabolic issues associated with the condition may provide unique benefits. A variety of nutritional supplements targeting some aspect of the AUD responses are available or have been proposed [8][9][10][11][12][13][14][15][16][17][18][19][20]. However, none have corrected the disruptions in macronutrient metabolism that lead to hepatic steatosis [11].…”

Section: Introductionmentioning

confidence: 99%

Essential Amino Acid Supplement Lowers Intrahepatic Lipid despite Excess Alcohol Consumption

et al. 2020

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Excess alcohol consumption is a top risk factor for death and disability. Fatty liver will likely develop and the risk of liver disease increases. We have previously demonstrated that an essential amino acid supplement (EAAS) improved protein synthesis and reduced intrahepatic lipid in the elderly. The purpose of this exploratory pilot study was to initiate the evaluation of EAAS on intrahepatic lipid (IHL), body composition, and blood lipids in individuals with mild to moderate alcohol use disorder (AUD). Following consent, determination of eligibility, and medical screening, 25 participants (18 males at 38 ± 15 years/age and 7 females at 34 ± 18 years/age) were enrolled and randomly assigned to one of two dosages: a low dose (LD: 8 g of EAAS twice/day (BID)) or high dose (HD: 13 g of EAAS BID). Five of the twenty-five enrolled participants dropped out of the intervention. Both groups consumed the supplement BID for 4 weeks. Pre- and post-EAAS administration, IHL was determined using magnetic resonance imaging/spectroscopy, body composition was analyzed using dual-energy X-ray absorptiometry, and blood parameters were measured by LabCorp. T-tests were used for statistical analysis and considered significant at p < 0.05. While there was no significant change in IHL in the LD group, there was a significant 23% reduction in IHL in the HD group (p = 0.02). Fat mass, lean tissue mass, bone mineral content, and blood lipids were not altered. Post-EAAS phosphatidylethanol was elevated and remained unchanged in LD at 407 ± 141 ng/mL and HD at 429 ± 196 ng/mL, indicating chronic and excess alcohol consumption. The HD of the proprietary EAAS formulation consumed BID seemed to lower IHL in individuals with mild to moderate AUD. We suggest that further studies in a larger cohort be conducted to more completely address this important area of investigation.

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Associations between Dietary Nutrient Intakes and Hepatic Lipid Contents in NAFLD Patients Quantified by 1H-MRS and Dual-Echo MRI

Cited by 46 publications

References 39 publications

Insoluble dietary fibre intake is associated with lower prevalence of newly-diagnosed non-alcoholic fatty liver disease in Chinese men: a large population-based cross-sectional study

Insoluble dietary fibre intake is associated with lower prevalence of newly-diagnosed non-alcoholic fatty liver disease in Chinese men: a large population-based cross-sectional study

Dietary Composition Independent of Weight Loss in the Management of Non-Alcoholic Fatty Liver Disease

Essential Amino Acid Supplement Lowers Intrahepatic Lipid despite Excess Alcohol Consumption

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