Associations between exposure to different heavy metals and self-reported erectile dysfunction: a population-based study using data from the 2001-2004 National Health and Nutrition Examination Survey

Liu, Chunhui; Mao, Weipu; You, Zonghao; Xu, Bin; Chen, Shuqiu; Wu, Jianping; Sun, Chao; Chen, Ming

doi:10.1007/s11356-022-20910-x

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…According to Massachusetts Male Aging Study (MMAS) ( 20 ), trained interviewers asked male participants 20 years and older a single question to assess their ability to maintain an erection: “Many men experience problems with sexual intercourse. How would you describe your ability to get and keep an erection adequate for satisfactory intercourse?” Participants had the following options to describe their erectile response: “always able or almost always able to get and keep an erection,” “usually able to get and keep an erection,” “sometimes able to get and keep an erection,” “never able to get and keep an erection.” We define “sometimes able or never able” as having erectile dysfunction and “always or almost always able and usually able” as not having erectile dysfunction, which is consistent with previous studies ( 12 , 13 , 21 , 22 ).…”

Section: Methodssupporting

confidence: 86%

“…Participants had the following options to describe their erectile response: "always able or almost always able to get and keep an erection, " "usually able to get and keep an erection, " "sometimes able to get and keep an erection, " "never able to get and keep an erection." We define "sometimes able or never able" as having erectile dysfunction and "always or almost always able and usually able" as not having erectile dysfunction, which is consistent with previous studies (12,13,21,22).…”

Section: Erectile Dysfunction Assessmentsupporting

confidence: 89%

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Dietary metal intake and the prevalence of erectile dysfunction in US men: Results from National Health and Nutrition Examination Survey 2001–2004

Liu

Zhang

et al. 2022

Front. Nutr.

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BackgroundErectile dysfunction (ED) mainly affects men over 40 years of age and is a common clinical condition. In addition to hypertension and diabetes, environment, and lifestyle are also significantly associated with erectile dysfunction. The relationship between dietary trace metal intake and ED has not been studied.Materials and methodsData on participants were obtained from the National Health and Nutrition Examination Survey for this study, and those with incomplete information on clinical variables were excluded. Dose-response curve analysis was used to investigate the relationship between dietary trace metal intake and ED prevalence. Multivariate logistic regression analysis was used to adjust for confounders to further investigate the relationship between dietary trace metal intake and ED prevalence. 1:1 propensity score matching (PSM) was performed to adjust for differences between clinical variables for data reanalysis to confirm the reliability of the results.ResultsA total of 3,745 individuals were included in the study, including 1096 ED patients and 2,649 participants without ED. Dietary intake of trace metals (Mg, Zn, Cu, and Se) was significantly higher in participants without ED than in ED patients (all P < 0.001). Dose-response curve analysis showed a significant negative association between these dietary metal intakes and ED prevalence (all P < 0.001). Multivariate logistic regression analysis adjusted for confounders (age, education, BMI, annual household income, hypertension, diabetes, marital status, race, and current health status) revealed that increased dietary metal intake reduced the odds ratio of ED. 1:1 PSM reanalysis further confirmed the validity of the results.ConclusionIncreasing dietary intake of trace metals (magnesium, zinc, copper, and selenium) within the upper limit is beneficial in reducing the prevalence of ED.

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Section: Methodssupporting

confidence: 86%

Section: Erectile Dysfunction Assessmentsupporting

confidence: 89%

Dietary metal intake and the prevalence of erectile dysfunction in US men: Results from National Health and Nutrition Examination Survey 2001–2004

Liu

Zhang

et al. 2022

Front. Nutr.

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“…And the Massachusetts Male Aging Study (MMAS) single question was used, as it has been shown to be a validated tool for population-based studies [29]. ED was defined as those who kept the answer options "sometimes able" or "never able", and non-ED was defined as those who kept the answer options "usually able" or "almost or almost always able" [30][31][32][33].…”

Section: Main Outcomesmentioning

confidence: 99%

Higher oxidative balance score was associated with decreased risk of erectile dysfunction: a population-based study

Xu,

Chu,

Lei

et al. 2024

Nutr J

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Background Erectile dysfunction (ED) is a prevalent condition that is thought to be significantly impacted by oxidative stress. The oxidative balance score (OBS) has been built to characterize the state of antioxidant/pro-oxidant balance. There is less known regarding the relationship of OBS with ED. Methods This study conducted cross-sectional analyses on 1860 males who participated in the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2004. OBS was constructed by the 16 dietary components and 4 lifestyle factors. Self-reported ED was defined as men who indicated that they “never” or “sometimes” could achieve or keeping an erection adequate for satisfactory intercourse. Multivariate logistic regression models were applied to examine the association between OBS and the risk of ED. Results Among 1860 participants, the median OBS was 20 (IQR 15–26), and OBS was lower in males with ED vs. those without ED (P = 0.001). The results of our analyses indicated a negative correlation between OBS and ED among male subjects. Specifically, each one-unit increase in the continuous OBS was relate to 3% reduction in the odds of ED after full adjustment. Moreover, when extreme OBS quartiles were compared, the adjusted odds ratio (95% confidence interval) for the 4th OBS category was 0.53 (0.32 to 0.88) after full adjustment (P for trend < 0.05). There was also statistical significance in the relationships between dietary/lifestyle OBS with ED, and the association between lifestyle OBS and ED may be even tighter. For each unit increase in lifestyle OBS, the odds of ED decreased by 11% after full adjustment. Conclusion Higher OBS was associated with reduced risk of ED in U.S. males. These findings suggested that adopting an antioxidant-rich diet and engaging in antioxidant-promoting lifestyle behaviors may contribute to a lower incidence of ED. These results provided recommendations for a comprehensive dietary and lifestyle antioxidants for ED patients.

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Prenatal exposure to dibutyl phthalate contributes to erectile dysfunction in offspring male rats by activating the RhoA/ROCK signalling pathway

Liu,

Li,

Wang

et al. 2024

Toxicology

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Associations between exposure to different heavy metals and self-reported erectile dysfunction: a population-based study using data from the 2001-2004 National Health and Nutrition Examination Survey

Cited by 4 publications

References 39 publications

Dietary metal intake and the prevalence of erectile dysfunction in US men: Results from National Health and Nutrition Examination Survey 2001–2004

Dietary metal intake and the prevalence of erectile dysfunction in US men: Results from National Health and Nutrition Examination Survey 2001–2004

Higher oxidative balance score was associated with decreased risk of erectile dysfunction: a population-based study

Prenatal exposure to dibutyl phthalate contributes to erectile dysfunction in offspring male rats by activating the RhoA/ROCK signalling pathway

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