Associations between exposure to polycyclic aromatic hydrocarbons and glucose homeostasis as well as metabolic syndrome in nondiabetic adults

Hu, Hui; Kan, Haidong; Kearney, Gregory D.; Xu, Xiaohui

doi:10.1016/j.scitotenv.2014.09.085

Cited by 78 publications

(36 citation statements)

References 68 publications

(62 reference statements)

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“…There is increasing evidence that early-life exposure to environmental chemicals may play a significant role in the global obesity epidemic 37–41. It is important to note that currently, efforts are being made to reduce the exposure to some of these chemicals.…”

Section: Resultsmentioning

confidence: 99%

“…The goal of this review is to highlight evidence linking early-life exposure to chemicals in our environment with MetS in the progeny into adulthood. There is considerable evidence linking exposure to polyaromatic hydrocarbons, bisphenol A, phthalates, per-fluorinated chemicals, polychlorinated biphenyls (PCBs), organochlorine pesticides, and organotins to metabolic perturbations; these chemicals have been recently reviewed in detail elsewhere 37–41. In this review, we focus on a suite of chemicals that are common contaminants associated with food production (pesticides) and processing (acrylamides), in addition to chemicals ubiquitously found in our household goods (flame retardants) and drinking water (heavy metals).…”

Section: Environmental Chemical Exposures During Pregnancy and The Dementioning

confidence: 99%

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Early-life chemical exposures and risk of metabolic syndrome

Long

Holloway

2017

DMSO

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The global prevalence of obesity has been increasing at a staggering pace, with few indications of any decline, and is now one of the major public health challenges worldwide. While obesity and metabolic syndrome (MetS) have historically thought to be largely driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease trends. There is now increasing evidence to suggest that exposure to synthetic chemicals in our environment may also play a key role in the etiology and pathophysiology of metabolic diseases. Importantly, exposures occurring in early life (in utero and early childhood) may have a more profound effect on life-long risk of obesity and MetS. This narrative review explores the evidence linking early-life exposure to a suite of chemicals that are common contaminants associated with food production (pesticides; imidacloprid, chlorpyrifos, and glyphosate) and processing (acrylamide), in addition to chemicals ubiquitously found in our household goods (brominated flame retardants) and drinking water (heavy metals) and changes in key pathways important for the development of MetS and obesity.

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Section: Resultsmentioning

confidence: 99%

Section: Environmental Chemical Exposures During Pregnancy and The Dementioning

confidence: 99%

Early-life chemical exposures and risk of metabolic syndrome

Long

Holloway

2017

DMSO

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“…The values of TEF for each PAH are shown in Table 1. Furthermore, the adverse effects of PAHs have been highlighted not only for a variety of cancers but also for the nongenotoxic diseases (such as diabetes mellitus (DM) and cardiovascular disorders) (Burstyn et al, 2005;Grant, 2009;Hu et al, 2015). The incremented incidence of dietary intake of PAHs has resulted in the metabolism defects due to their persistent bioaccumulation in food chain.…”

Section: Classification Of Pah and Their Toxicitymentioning

confidence: 99%

“…The PAHs' resistance against degradation hinders the metabolic activity of glucose homeostasis and β-cell function to act as the potential cause of the Type 2 diabetes (T2DM) (Andersen et al, 2012;Raaschou-Nielsen et al, 2013;Alshaarawy et al, 2014). These non-genotoxic effects of the continuous environmental and dietary (charred and broiled meat) exposure has become one of the significant casual factors contribution to the development of metabolic syndrome in terms of dyslipidemia and raised blood pressure (Hu et al, 2015).…”

Section: Classification Of Pah and Their Toxicitymentioning

confidence: 99%

Review of PAH contamination in food products and their health hazards

Bansal

Kim

2015

Environment International

302

113

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“…Consequently the European Food Safety Authority has made a detailed assessment of human exposure from dietary sources (EFSA, 2008). In addition to the cancer risk, PAH exposure has been linked to the onset of diabetes mellitus (Yang et al 2014;Alshaarawy, et al 2014), metabolic syndrome (Brocato et al 2014;Hu et al 2015), and cardiovascular conditions (Xu et al 2010;Feng et al 2014). Since all exposure sources can contribute to the body burden of PAH, quantitative evaluation of exposure pathways is important if health risk is to be minimised.…”

Section: Introductionmentioning

confidence: 99%

Urinary metabolites of polycyclic aromatic hydrocarbons in Saudi Arabian schoolchildren in relation to sources of exposure

Alghamdi

Alam

Stark

et al. 2015

Environmental Research

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Polycyclic aromatic hydrocarbons contain a number of known carcinogenic compounds, and urinary biomarkers have been widely used as a measure of exposure but quantitative relationships with exposure variables have proved elusive. This study aimed to quantify the relationship between exposures to phenanthrene and pyrene from atmospheric and dietary sources with the excretion of 1-hydroxypyrene and hydroxyphenanthrenes in urine as biomarkers of exposure. The study population consisted of 204 male schoolchildren attending three schools in different parts of Jeddah, Saudi Arabia who provided urine samples on each of three consecutive days. Outdoor air measurements of polycyclic aromatic hydrocarbons were made at the schools and the children provided information on diet, exposure to environmental tobacco smoke and incense, and various lifestyle factors through a questionnaire. Mixed models with random effects for subjects nested within site were fitted in order to examine the relationship between exposure variables and urinary PAH metabolites. A unit increase (1 ng m(-3)) in ambient pyrene (particulate plus gaseous phase) was associated with a 3.5% (95% CI: 1.01%, 5.13%) increase in urinary 1-hydroxypyrene concentration. A unit increase in ambient phenanthrene was associated with a 1.01% (95% CI: 0.03%, 2.02%) increase in total hydroxyphenanthrene concentrations. Consumption of chargrilled food increased the 1-hydroxypyrene and hydroxyphenanthrene concentrations by 24% (95% CI: 11%, 37%) and 17% (95% CI: 8%, 26%) respectively. We did not find evidence of association for environmental tobacco smoke exposure or incense burning. It is concluded that both respiratory exposure and consumption of chargrilled food are considerable sources of PAH exposure in this population as reflected by concentrations of urinary biomarkers.

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Associations between exposure to polycyclic aromatic hydrocarbons and glucose homeostasis as well as metabolic syndrome in nondiabetic adults

Cited by 78 publications

References 68 publications

Early-life chemical exposures and risk of metabolic syndrome

Early-life chemical exposures and risk of metabolic syndrome

Review of PAH contamination in food products and their health hazards

Urinary metabolites of polycyclic aromatic hydrocarbons in Saudi Arabian schoolchildren in relation to sources of exposure

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