Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study

Boonpor, Jirapitcha; Parra‐Soto, Solange; Petermann‐Rocha, Fanny; Ferrari, Gérson; Welsh, Paul; Pell, Jill P.; Sattar, Naveed; Gill, Jason M.R.; Ho, Frederick K.; Gray, Stuart R.; Celis‐Morales, Carlos

doi:10.1136/bmjdrc-2020-001865

Cited by 32 publications

(24 citation statements)

References 33 publications

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“…34 Therefore, our findings support this negative association but with a longer follow-up time. On top of this, the current work confirmed the negative association between relative grip strength and incident T2D, seen previously, 35 in the largest prospective cohort study so far.…”

Section: Discussionsupporting

confidence: 90%

Combined association of walking pace and grip strength with incident type 2 diabetes

Boonpor

Parra‐Soto

Petermann‐Rocha

et al. 2022

Scandinavian Med Sci Sports

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The current study aims to investigate the combined association of walking pace and grip strength with incident type 2 diabetes (T2D). A total of 205 738 participants (mean age 56.6 ± 8.1 years, 115 139 [56.0%] women) without diagnosed or unknown diabetes at baseline from the UK Biobank study were included in this prospective study. Walking pace was self-reported as slow, average, or brisk. Grip strength was measured using a dynamometer and classified as weak, average, and strong. The combined association of walking pace and grip strength with incident T2D was investigated using Cox-proportional hazards models with a 2year landmark analysis. The additive interaction was conducted by estimating relative excess risk due to interaction (RERI). After the median follow-up period of 5.4 years (interquartile range: 4.8-6.5), 5082 (2.5%) participants were diagnosed with T2D. Compared to brisk-strong individuals (reference group), people who were slow-weak had a higher risk of T2D (hazard ratio: 1.64 [95% CI, 1.42-1.89]) after adjusting for all covariates. There were dose-response gradients across both walking pace and grip strength variables. There was a modest amount of negative additive interaction (RERI; −0.06 [95% CI, −0.16; −0.01]. To conclude, slower pace and weaker grip strength were associated with a higher risk of developing T2D, independent of sociodemographics, lifestyle, and adiposity. Combining walking pace and grip strength might be a practical approach to screening people who are at increased risk of developing T2D.

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Section: Discussionsupporting

confidence: 90%

Combined association of walking pace and grip strength with incident type 2 diabetes

Boonpor

Parra‐Soto

Petermann‐Rocha

et al. 2022

Scandinavian Med Sci Sports

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“…This study also found a strong relationship between type 2 DM and age and body mass index. 5 Increases in fasting glucose are inversely correlated with grip strength, according to earlier research. A study with 1664 people conducted in the US found no correlation between grip strength and 2hPG in either men or women, but a significant inverse association between fasting glucose and grip strength in males but not in women.…”

Section: Discussionmentioning

confidence: 79%

Risk factors for decreased hand grip strength in type 2 diabetes mellitus patients at the Tabanan Public Health Center II

Darmawan¹,

Paramitha

Putrawan³

2022

IJBS

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Introduction: The condition of decreased muscle mass and function in people with type 2 diabetes mellitus (DMT2) will lead to a significant effect on the decline in quality of life. A commonly found manifestation of sarcopenia is the presence of a decrease in the strength of the hand grip. Other research showed a significant inverse relationship between the strength of the hand grip and DMT2. But to date, there are still few studies that assess the factors that cause a decrease in the strength of the hand grip in DMT2 patients. This study aims to evaluate risk factors that are related to the strength of the decrease in the strength of the hand grip in patients with DMT2. Methods: Cross-sectional analytical research. The data was taken through interviews, physical examinations and data collection of laboratory examination results at the general polyclinic of the Tabanan Public Health Center II. The bivariate test used chi-square and the multivariate analysis with logistic regression was used in assessing the magnitude of influence between variables that have a meaningful relationship with HGS and looking for the magnitude of the adjusted odd ratio (AOR) value. Results: The study discovered a strong correlation between age (p=0.002), body mass index (p=0.002), and fasting blood sugar levels (p=0.001) and hand grip strength. In the multivariate analysis, it was found that the relationship of age more than 50 years to the decrease in hand grip strength was greater than high fasting blood sugar levels, while no significant relationship was found on excess nutritional status in this multivariate analysis (p=0.44). Conclusion: Age, body mass index, and fasting blood sugar levels are the risk factors for decreased hand grip strength in type 2 diabetes mellitus patients.

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“…In a cohort study, the relationship between relative muscle mass (i.e., total skeletal muscle mass per body weight) and the risk of incident type 2 DM was stronger in young and middle-aged adults (<50 years) [ 4 ]. In a UK biobank prospective cohort study, the association between low grip strength per body weight and the risk of type 2 DM incidence was stronger in individuals aged <55 years [ 20 ]. A Japanese study on the relationship between relative HGS and prediabetes incidence showed a stronger inverse relationship in young adults (<40 years) than in older adults [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Low relative hand grip strength is associated with a higher risk for diabetes and impaired fasting glucose among the Korean population

Lee

Khang

et al. 2022

PLoS ONE

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Objective This study investigated the association between relative hand grip strength (HGS) and glycemic status, such as impaired fasting glucose (IFG) and diabetes, using data from the Korea National Health and Nutrition Examination Survey (KNHANES). Methods We performed a cross-sectional study using the data from the KNHANES of 27,894 individuals from 2014 to 2019. Relative HGS was defined as the absolute HGS divided by body mass index and divided into quartiles in men and women. Odds ratios (OR) for diabetes and IFG were calculated using multivariate logistic regression analysis. All analyses were stratified by sex, and subgroup analysis was age-stratified. Results The lowest relative HGS quartile had a significant increase in the risk for diabetes (men: OR 2.72, 95% confidence interval [CI] 2.12–3.50; women: OR 3.38, 95% CI 2.70–4.24) and IFG (men: OR 1.35, 95% CI 1.15–1.59; women: OR 1.60, 95% CI 1.40–1.84). The ORs for diabetes and IFG according to the decreasing quartiles of relative HGS gradually increased in both sexes (P for trend <0.001). ORs and 95% CI of the lowest relative HGS quartile for diabetes were higher in the younger age group than that of the older age group (men: 4.47 and 2.80–7.14 for young adults; 2.41 and 1.37–4.25 for older adults; women: 5.91 and 3.06–9.38 for young adults; 1.47 and 0.92–2.33 for older adults). ORs and 95% CI for IFG was similar with the trend of ORs for diabetes (men: 1.80 and 1.43–2.26 for young adults; 1.17 and 0.75–1.84 for older adults; women: 2.20 and 1.77–2.72 for young adults; 1.33 and 0.86–2.07 for older adults). Conclusion Lower relative HGS was associated with a higher risk of not only diabetes but also IFG in both sexes. These trends were stronger in younger adults than in older adults.

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Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study

Cited by 32 publications

References 33 publications

Combined association of walking pace and grip strength with incident type 2 diabetes

Combined association of walking pace and grip strength with incident type 2 diabetes

Risk factors for decreased hand grip strength in type 2 diabetes mellitus patients at the Tabanan Public Health Center II

Low relative hand grip strength is associated with a higher risk for diabetes and impaired fasting glucose among the Korean population

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