Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies

Moon, Shinje; Chung, Haegeun; Yu, Jae Myung; Yoo, Hyung Joon; Park, Jung Hwan; Kim, Dong Sun; Park, Young Joo

doi:10.3803/enm.2018.33.4.473

Cited by 80 publications

(82 citation statements)

References 85 publications

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“…In the meta-analysis conducted by Lee et al involving a group of 10,648 PTC cases, it was shown that AIT was substantially more frequent in patients with PTC, compared to patients with benign tumours [18]. Another meta-analysis of 71 articles (44,034 patients with PTC) also indicated the relationship between PTC and AIT [19]. Moreover, Niedziela et al…”

Section: Casementioning

confidence: 97%

Papillary thyroid cancer in three children

Szmit-Domagalska

Horodnicka‐Józwa

Petriczko

et al. 2019

pedm

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Introduction: Thyroid cancers (TC) are rare diseases in the pediatric population and represents 0.5-3% of all malignant tumors in children. Differentiated thyroid cancer (DTC) is a major TC in children. Every patient under 18 years of age diagnosed with a thyroid nodule should undergo a detailed medical examination. The screening test for children with an increased risk for DTC is ultrasound examination of the neck. Both ultrasound and clinical images of a tissue lesion are more important than its size. It should also be emphasized that autoimmune thyroiditis (AIT), a comorbid condition for TC, is increasingly often diagnosed in young patients. Because of the rare incidence of this kind of cancer, we present 3 case studies of patients with papillary thyroid carcinoma, hospitalized in the

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Section: Casementioning

confidence: 97%

Papillary thyroid cancer in three children

Szmit-Domagalska

Horodnicka‐Józwa

Petriczko

et al. 2019

pedm

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“…Some studies suggest that HT is the result of the combined action of genetic susceptibility and environmental factors, but the exact mechanism is still unclear (2). Clinical studies have suggested that HT is associated with the occurrence of papillary thyroid carcinoma (3). One study suggested that in normal thyroid function, HT can also cause neuroinflammation, leading to emotional alterations (4).…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Hashimoto's Thyroiditis–Related Thyroid Hormone Levels and 25-Hydroxyvitamin D

2020

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The purpose of this study was to further clarify the association of Hashimoto's thyroiditis (HT) and vitamin D deficiency, and to seek the connection between them and related influencing factors. Methods: Data were obtained from subjects who underwent health examinations from January 2018 to December 2018. The diagnosis of HT was based on: antithyroid peroxidase antibody (TPO-Ab) levels >35 IU/ml and/or antithyroglobulin antibody (Tg-Ab) levels >40 IU/ml. Based on the Endocrine Society guidelines, 25-hydroxyvitamin D [25(OH)D] levels ≥30.0 ng/ml were classified as a vitamin D sufficiency; those between 20 and 29.9 ng/ml, as an insufficiency; and those <20 ng/ml, as a deficiency. All statistical analysis was performed by software R. Results: Of a total of 75,436 individuals who were physically examined, 5,656 of them had 25(OH)D levels tested at the same time; 5,230 were enrolled. The level of 25(OH)D in the non-HT group was higher than that in the HT group. Multiple regression analysis showed that HT was statistically significantly correlated with being male, body mass index (BMI), waist circumference, and thyroid-stimulating hormone (TSH). TSH levels in the insufficiency group and deficiency group were higher than those in the sufficiency group. Free triiodothyronine (FT3) and thyroxine (FT4) levels in the insufficiency group and deficiency group were lower than those in the sufficiency group. 25(OH)D increased by 1 ng/ml at the normal reference level, with an increase of 2.78 ng/dl in FT4 concentration and a decrease of 0.17 mIU/L in TSH. Conclusions: Patients with HT present with a reduced 25(OH)D level, and TSH is an independent risk factor for HT. TSH is negatively correlated with 25(OH)D level. FT3 and FT4 levels were positively correlated with 25(OH)D levels.

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“…The female prevalence observed in most of the thyroid lesions is also dominant in PTC w/ HT where cancer incidence is approximately five times higher in females than in males [15]. A meta-analysis on 71 observational studies reported that PTCs w/ HT are more likely to be multifocal but in general have favorable clinicopathological features including less extrathyroid extension, lymph node and distant metastases, and recurrence than PTCs w/o HT [16].…”

Section: Introductionmentioning

confidence: 99%

Genetic relationship between Hashimoto`s thyroiditis and papillary thyroid carcinoma with coexisting Hashimoto`s thyroiditis

et al. 2020

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Hashimoto's thyroiditis (HT) is present in the background of around 30% of papillary thyroid carcinomas (PTCs). The genetic predisposition effect of this autoimmune condition is not thoroughly understood. We analyzed the microarray expression profiles of 13 HT, eight PTCs with (w/) coexisting HT, six PTCs without (w/o) coexisting HT, six micro PTCs (mPTCs), and three normal thyroid (TN) samples. Based on a false discovery rate (FDR)adjusted p-value � 0.05 and a fold change (FC) > 2, four comparison groups were defined, which were HT vs. TN; PTC w/ HT vs. TN; PTC w/o HT vs. TN; and mPTC vs. TN. A Venn diagram displayed 15 different intersecting and non-intersecting differentially expressed gene (DEG) sets, of which a set of 71 DEGs, shared between the two comparison groups HT vs. TN \ PTC w/ HT vs. TN, harbored the relatively largest number of genes related to immune and inflammatory functions; oxidative stress and reactive oxygen species (ROS); DNA damage and DNA repair; cell cycle; and apoptosis. The majority of the 71 DEGs were upregulated and the most upregulated DEGs included a number of immunoglobulin kappa variable genes, and other immune-related genes, e.g., CD86 molecule (CD86), interleukin 2 receptor gamma (IL2RG), and interferon, alpha-inducible protein 6 (IFI6). Upregulated genes preferentially associated with other gene ontologies (GO) were, e.g., STAT1, MMP9, TOP2A, and BRCA2. Biofunctional analysis revealed pathways related to immunogenic functions. Further data analysis focused on the set of non-intersecting 358 DEGs derived from the comparison group of HT vs. TN, and on the set of 950 DEGs from the intersection of all four comparison groups. In conclusion, this study indicates that, besides immune/ inflammation-related genes, also genes associated with oxidative stress, ROS, DNA

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Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies

Cited by 80 publications

References 85 publications

Papillary thyroid cancer in three children

Papillary thyroid cancer in three children

Correlation Between Hashimoto's Thyroiditis–Related Thyroid Hormone Levels and 25-Hydroxyvitamin D

Genetic relationship between Hashimoto`s thyroiditis and papillary thyroid carcinoma with coexisting Hashimoto`s thyroiditis

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