Associations between <i>TAB2</i> Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population

Huang, Xingming; Shen, Can; Zhang, Yan; Li, Qin; Li, Kai; Wang, Yanyun; Song, Yaping; Su, Minggang; Zhou, Bin; Wang, Wei

doi:10.1155/2019/8012979

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…The key genes identified in subtype IV are: TAB3 gene forms a ternary complex with protein kinase MAPK3K7/ TAK1 leading to the stimulation of pro-inflammatory cytokine and NFkappa signaling activation (Figure 8d). TAB2 gene exhibits polymorphism and is associated with ovarian cancer susceptibility [72]. TAB3 gene overexpression is associated with poor survival in human esophageal squamous cell carcinoma [73].…”

Section: Subtype IV -Stroma (Microenvironment Of Tumor) Genesmentioning

confidence: 99%

Unsupervised subtyping and methylation landscape of pancreatic ductal adenocarcinoma

Roy¹,

Singh²,

Gupta

2021

Heliyon

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Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive form of pancreatic cancer that typically manifests itself at an advanced stage and does not respond to most treatment modalities. The survival rate of a PDAC patient is less than 5%, with a median survival of just a couple of months. A better understanding of the molecular pathology of PDAC is needed to guide research for the development of better clinical treatment modalities for PDAC patients. Gene expression studies performed to date have identified different subtypes of PDAC with prognostic and clinical relevance. Subtypes identified to date are highly heterogeneous since pancreatic cancer is heterogeneous cancer. Tumor microenvironment and stroma constitute a major chunk of PDAC and contribute to the heterogeneity. Better subtyping methods are need of the hour for better prognosis and classification of PDAC for future personalized treatment. In this work, we have performed an integrated analysis of DNA methylation and gene expression datasets to provide better mechanistic and molecular insights into Pancreatic cancers, especially PDAC. The use of varied and diverse datasets has provided valuable insights into different cancer types and can play an integral role in revealing the complex nature of underlying biological mechanisms. We performed subtyping of TCGA-PAAD gene expression and methylation datasets into different subtypes using state-of-the-art normalization methods and unsupervised clustering methods that reveal latent hidden factors, leading to additional insights for subtyping. Differential expression and differential methylation were performed for each of the subtypes obtained from clustering. Our analysis gave a consensus of five cluster solution with relevant pathways like MAPK, MET. The five subtypes corresponded to the tumor and stromal subtypes. This analysis helps in distinguishing and identifying different subtypes based on enriched putative genes. These results help propose novel experimentally-verifiable PDAC subtyping and demonstrate that using varied data sets and integrated methods can contribute to disease prognostication and precision medicine in PDAC treatment.

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Section: Subtype IV -Stroma (Microenvironment Of Tumor) Genesmentioning

confidence: 99%

Unsupervised subtyping and methylation landscape of pancreatic ductal adenocarcinoma

Roy¹,

Singh²,

Gupta

2021

Heliyon

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“…More pervasively, binding with TAB2 will promote cardiovascular development and maintain extracellular matrix (ECM) homeostasis [ 21 , 22 ]. It has been reported to participate in activating transcription factor NF- κ B signaling pathway, which makes it contribute to the initiation of epithelial ovarian cancer [ 23 ]. Moreover, TAB2 functions as a mediator of drug resistance and might be a potential new target for reversing drug resistance and enhancing antiestrogen effects in breast cancer [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway

et al. 2022

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Background. Transforming growth factor β1-activated kinase 1 binding protein 2 (TAB2) mediates a variety of biological processes through activated nuclear factor κ-light-chain-enhancer of activated B cell (NF-κB) signaling pathways. TAB2 has been reported to be upregulated in a variety of tumors. However, little is known about its potential role in oral squamous cell carcinoma (OSCC). Material and Methods. Patients’ clinicopathological and transcription data were obtained from The Cancer Genome Atlas (TCGA) database. Immunohistochemistry staining was used to determine TAB2 expression in OSCC tissues (IHC). The expression of TAB2 in OSCC cell lines was detected by western blotting. The CCK-8 test and flow cytometry assay were utilized to evaluate cell proliferation, apoptosis, and cell cycle in OSCC cell lines. Enrichment analysis and identification of predicted signaling pathways were performed by Gene Ontology and KEGG analysis. Finally, the expression of downstream signal molecules was performed using western blotting to validate the mechanism investigations. Results. TAB2 expression level was aberrantly upregulated in OSCC patients. TAB2 expression was shown to be inversely associated to prognosis. The phenotypic of OSCC cells was considerably impacted by TAB2. OSCC cells with deleted TAB2 exhibit decreased proliferation and increased apoptosis. Additionally, OSCC progression is aided by TAB2 overexpression. Further mechanism studies showed that TAB2 could regulate the progression of OSCC by mediating the upregulation of EMT and PI3K-AKT signaling pathways. Conclusion. This study sheds light on the carcinogenic role of TAB2 in OSCC and provides a potential therapeutic strategy.

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“…TAB2 is also indispensable for B cell activation leading to Ag-specific Ab responses [ 18 ]. Additionally, TAB2 gene polymorphism was associated with Epithelial ovarian cancer susceptibility [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population

et al. 2021

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Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected companies with 588 cases and 537 healthy control subjects. Five selected single nucleotide polymorphisms (SNPs) in TAB2,incoluding rs2744434, rs521845, rs652921, rs7896, rs9485372, were genotyped after a collection of DNA samples. Evident differences in participants between the case group and the control group reveals the result that people with the TAB2 has a high probability of getting NIHL. The results show that rs521845 is deeply associated with the risk of NIHL and is available for the diagnosis in the future.

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Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population

Cited by 4 publications

References 31 publications

Unsupervised subtyping and methylation landscape of pancreatic ductal adenocarcinoma

Unsupervised subtyping and methylation landscape of pancreatic ductal adenocarcinoma

TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway

Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population

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