Associations between labial and whole salivary flow rates, systemic diseases and medications in a sample of older people

Smidt, D.; Torpet, Lis Andersen; Nauntofte, Birgitte; Heegaard, Karen Margrethe; Pedersen, Anne Marie Lynge

doi:10.1111/j.1600-0528.2010.00554.x

Cited by 85 publications

(117 citation statements)

References 53 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…Smidt et al included the question, 'Have you had a daily sensation of dry mouth for more than 3 months?' in their assessment of xerostomia in a study of 668 community dwelling elderly (over 65 years) subjects [ 12 ]. The rates of xerostomia were lower than the above studies, 12.3 % overall and rising to 16.6 % in those taking two to three medications.…”

Section: Dose Duration and Number Of Medicationsmentioning

confidence: 91%

Medication-Induced Dry Mouth

Proctor

2014

Dry Mouth

View full text Add to dashboard Cite

A wide range of medications have been found to be associated with xerostomia, the subjective symptom of dry mouth. The assessment of medication-induced xerostomia (MIX) is usually made through a subject's responses to relevant questions or the use of visual analogue scales whereby the subject is asked to rate the severity of their oral dryness. It is uncertain how much MIX is accompanied or can be ascribed to medication-induced salivary gland hypofunction and reduced secretion of saliva. MIX in older age groups is associated with the number of medications being taken and is higher than seen in the younger subjects. Many medications cause xerostomia as a side effect, but some of these, for example, selective serotonin reuptake inhibitors, do not appear to cause salivary gland hypofunction. However, there have been relatively few studies assessing objective changes in salivary fl ow in response to medications. The salivary refl ex has peripheral and central components which can be the targets of medications, leading to interruption of the refl ex and medication-induced salivary gland dysfunction (MISGD) characterized by reduced production of saliva. The principal peripheral target is the cholinergic muscarinic (M3) receptor of salivary gland acinar cells which is blocked by antimuscarinic drugs used in the treatment of, for example, irritable bladder and chronic obstructive pulmonary disease. Tricyclic antidepressants not only have targets in the central nervous system but interact with and block muscarinic receptors in the periphery. Sympathetic nervemediated stimuli enhance salivary secretion, and there is no peripheral inhibition. Although adrenergic antagonists cause MIX, there is no evidence that they reduce salivary secretion. However, antihypertensive β-adrenoceptor blockers

show abstract

Section: Dose Duration and Number Of Medicationsmentioning

confidence: 91%

Medication-Induced Dry Mouth

Proctor

2014

Dry Mouth

View full text Add to dashboard Cite

show abstract

“…Among the drugs associated with decreased salivary flow, which can cause dry mouth, there are psycholeptics, psychoanaleptics, oral antidiabetics, respiratory agents, quinine, antihypertensive agents, urinary antispasmodics, glucosamine, non-steroidal anti-inflammatory drugs, opioids, ophthalmologic drugs and magnesium hydroxide [45]. Thus, it is possible that the prevalence of xerostomia found in in people with diabetes may be related, additionally, to the medications used to treat diabetes mellitus, its comorbidities and complications.…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of Prevalence of Xerostomia in Diabetes Mellitus

Lessa

Pires²,

Ceretta

et al. 2015

Int Arch Med

View full text Add to dashboard Cite

Background: As with other complications of diabetes mellitus, the occurrence of dry mouth can lead to a poor quality of life. Therefore, this study aimed to identify the prevalence of xerostomia in patients with diabetes mellitus through a systematic review and meta-analysis. Method: Systematic review and meta-analysis.Results: After the screening process, 23 studies were included in the meta-analysis. Overall, the incidence of dry mouth was investigated in 1979 people with diabetes (cases) and 1225 controls. The global prevalence of diabetes in xerostomia was 42.22% (95% CI: 33.97%-50.92%). In the analysis by specific subtype, the overall prevalence was 37.42% (95% CI: 22.33%-55.44%) among individuals with Type 1 diabetes and 46.09% (95% CI: 23.99%-69.85%) among those with type 2 diabetes. The prevalence of xerostomia found in Asia (49.01%; 95% CI: 32.08%-66.16%) was higher than that found in Europe (40.04%; 95% CI: 29.58%-51.50%) and America (38.39%; 95% CI: 23.63%-55.65%). Analysis of the case-control studies showed a statistically significant association between xerostomia and diabetes mellitus (OR=3.15; 95% CI: 2.11-4.70; p<0.001).

show abstract

Section: Introductionunclassified

“…Os ácinos da glândula parótida produzem mais fluido seroso rico em proteí-nas, as glândulas sublingual e submandibular tem produção de fluido mais rico em mucinas 2. A produção salivar é controlada pelo sistema nervoso autô-nomo e muitos fármacos podem a alterá-la qualitativa e quantitativamente 3 , aumentando o risco de desenvolvimento de lesões bucais 4,5 . Um estudo em idosos sugere que as estatinas estão entre as medicações associadas à redução do fluxo salivar 5 . Linfonodos cervicais fazem parte dos órgãos linfoides periféricos e participam da imunidade adaptativa, os antígenos são apresentados aos linfócitos pelas células apresentadoras de antígenos e proteínas do maior complexo de histocompatibilidade, iniciando assim a ativação de linfócitos e expansão clonal 6 .…”

Section: Introductionunclassified

Efeito da sinvastatina em dose imunossupressora sobre as glândulas salivares e linfonodos cervicais de ratos Wistar

Higashi

Xavier

Ramos

2015

Rev. da Fac. de Odontologia, UPF

View full text Add to dashboard Cite

IntroduçãoA saliva é uma mistura complexa e tem um papel fundamental na manutenção da integridade e proteção dos tecidos bucais e vias aéreas superiores, preparação do bolo alimentar, deglutição e fala 1 . A secreção, em sua grande parte, é realizada pelas glândulas salivares maiores 2 , que são formadas por células acinares e ductos. Os ácinos da glândula parótida produzem mais fluido seroso rico em proteí-nas, as glândulas sublingual e submandibular tem produção de fluido mais rico em mucinas 2. A produção salivar é controlada pelo sistema nervoso autô-nomo e muitos fármacos podem a alterá-la qualitativa e quantitativamente 3 , aumentando o risco de desenvolvimento de lesões bucais 4,5 . Um estudo em idosos sugere que as estatinas estão entre as medicações associadas à redução do fluxo salivar 5 . Linfonodos cervicais fazem parte dos órgãos linfoides periféricos e participam da imunidade adaptativa, os antígenos são apresentados aos linfócitos pelas células apresentadoras de antígenos e proteínas do maior complexo de histocompatibilidade, iniciando assim a ativação de linfócitos e expansão clonal 6 . As estatinas são inibidores da 3-hidroxi -3-metilglutaril coenzima A reductase (HMG-CoA) uma

show abstract

Associations between labial and whole salivary flow rates, systemic diseases and medications in a sample of older people

Cited by 85 publications

References 53 publications

Medication-Induced Dry Mouth

Medication-Induced Dry Mouth

Meta-Analysis of Prevalence of Xerostomia in Diabetes Mellitus

Efeito da sinvastatina em dose imunossupressora sobre as glândulas salivares e linfonodos cervicais de ratos Wistar

Contact Info

Product

Resources

About