Associations between liver function parameters and poor clinical outcomes in peritoneal dialysis patients

Song, Xiyu; Zha, Yang; Liu, Jing; He, Peng; He, Lijie

doi:10.1111/1744-9987.13926

Cited by 6 publications

(2 citation statements)

References 56 publications

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“…GGT resulted in being independent foretelling indicator of cardiovascular disease. In addition to that, GGT also occurred as an independent and strong indicator for cardiovascular related mortality in patients undergoing dialysis 10 . On the other hand, only a few studies are found related to the association of GGT with the risk of cardiovascular disease in predialysis chronic kidney disease patients.…”

Section: Resultsmentioning

confidence: 90%

Relationship Between Liver Function Tests & Cardiovascular Risk Factors in Stage 3-5 Pre-Dialysis Chronic Kidney Disease

Rehman¹,

Khan²,

Khattak³

et al. 2022

PJMHS

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Objectives: The main objective of this study was to evaluate the relation between liver function tests and biochemical cardiovascular risk factors in chronic kidney disease patients. Methodology: this study was conducted in Khyber Teaching Hospital Peshawar, from Ist May 2022 till 31st Oct, 2022. 250 patients in total were included in this study. All the people included in this study were chronic kidney disease patients at pre dialysis stage 3 to 5. Data collected included demographic information, liver function tests and biochemical cardiovascular risk factors. CKD-EPI equation was used to calculate glomerular filtration rate. Results: This study resulted in ALT being negatively correlated with C reactive protein and intact level of parathyroid hormone and positively correlated with glomerular filtration rate, triglyceride, calcifediol and albumin. Gamma-glutamyl transferase was negatively correlated with HDL cholesterol and positively correlated with glomerular filtration rate, triglycerides and C reactive protein. AST was negatively correlated with C reactive protein and intact level of parathyroid hormone and positively correlated with glomerular filtration rate, HDL cholesterol, albumin and calcifediol. In diabetic patients AST and ALT were positively correlated with glomerular filtration rate, additionally AST was also positively correlated with HDL cholesterol but negatively with intact parathyroid hormone. Gamma-glutamyl transferase had no correlation. In total population of the study and in diabetic group correlation analysis was run between glomerular filtration rate and biochemical cardiovascular risk factors, it resulted in GFR being negatively correlated with albuminuria, C reactive protein and intact parathyroid hormone and positively correlated with triglyceride, calcifediol and albumin. A partial correlation analysis, controlled for GFR, was also run between cardiovascular risk factors and LFTs. It resulted in no correlation between both. Practical implication: this study could be useful when planning the treatment of CKD patients with cardiovascular risk factors. Also in predicting the risk of cardiovascular disease in CKD patients based on the LFTs. It could also help initiate further reseach on related topics like the role of LFTs in predicting cardiovascular disease in CKD patients. Conclusion: this study concluded that relation between liver function tests and biochemical cardiovascular risk factors in chronic kidney disease patients could be the function of compromised glomerular filtration rate. Keywords: cardiovascular risk factors, chronic kidney disease, aspartate transaminase, gamma-glutamyl transferase, alanine transaminase

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Section: Resultsmentioning

confidence: 90%

Relationship Between Liver Function Tests & Cardiovascular Risk Factors in Stage 3-5 Pre-Dialysis Chronic Kidney Disease

Rehman¹,

Khan²,

Khattak³

et al. 2022

PJMHS

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“…36 PAB, a substance synthesized by the liver, and its associated markers provide insight into the nutritional status of the patient and highlight abnormalities in liver cell synthesis and metabolic functions. 63,64 The significant correlation between AST, T-BIL, D-BIL, G, A/G, PAB, and CDRV undersores the complex relationship between VPA and liver damage.…”

Section: Discussionmentioning

confidence: 99%

Factors Influencing Plasma Concentrations of Valproic Acid in Pediatric Patients With Epilepsy and the Clinical Significance of CYP2C9 Genotypes in Personalized Valproic Acid Therapy

Ma,

Yang,

et al. 2024

Therapeutic Drug Monitoring

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Background: The aim of this study was to investigate the factors affecting plasma valproic acid (VPA) concentration in pediatric patients with epilepsy and the clinical significance of CYP2C9 gene polymorphisms in personalized dosing using therapeutic drug monitoring and pharmacogenetic testing. Methods: The medical records of children with epilepsy who underwent therapeutic drug monitoring at our institution between July 2022 and July 2023 and met the inclusion criteria were reviewed. Statistical analysis was performed to determine whether age, sex, blood ammonia, liver function, kidney function, and other characteristics affected the concentration-to-dose ratio of VPA (CDRV) in these patients. To investigate the effect of CYP2C9 polymorphisms on CDRV, DNA samples were collected from patients and the CYP2C9 genotypes were identified using real-time quantitative PCR. Results: The mean age of 208 pediatric patients with epilepsy was 5.50 ± 3.50 years. Among these patients, 182 had the CYP2C9 *1/*1 genotype, with a mean CDRV (mcg.kg/mL.mg) of 2.64 ± 1.46, 24 had the CYP2C9 *1/*3 genotype, with a mean CDRV of 3.28 ± 1.74, and 2 had the CYP2C9 *3/*3 genotype, with a mean CDRV of 6.46 ± 3.33. There were statistical differences among these 3 genotypes (P < 0.05). The CDRV in these patients were significantly influenced by age, aspartate aminotransferase, total bilirubin, direct bilirubin, globulin, albumin/globulin ratio, prealbumin, creatinine, and CYP2C9 polymorphisms. In addition, multivariate linear regression analysis identified total bilirubin, direct bilirubin, and CYP2C9 polymorphisms as independent risk factors for high CDRV. Conclusions: Liver problems and mutations in the CYP2C9 gene increase VPA levels. This underscores the importance of considering these factors when prescribing VPA to children with epilepsy, thereby enhancing the safety and efficacy of the therapy.

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Clinical implications of persistent joint pain after gout flare

Liu,

Dong,

et al. 2024

Reumatología Clínica

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Associations between liver function parameters and poor clinical outcomes in peritoneal dialysis patients

Cited by 6 publications

References 56 publications

Relationship Between Liver Function Tests & Cardiovascular Risk Factors in Stage 3-5 Pre-Dialysis Chronic Kidney Disease

Relationship Between Liver Function Tests & Cardiovascular Risk Factors in Stage 3-5 Pre-Dialysis Chronic Kidney Disease

Factors Influencing Plasma Concentrations of Valproic Acid in Pediatric Patients With Epilepsy and the Clinical Significance of CYP2C9 Genotypes in Personalized Valproic Acid Therapy

Clinical implications of persistent joint pain after gout flare

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