Associations between lower urinary tract dysfunction and glycemic control in women with type 2 diabetes: A cross-sectional study

Tai, Huai‐Ching; Tai, Tong-Yuan; Yang, Wei‐Shiung; Wang, Shin-Wei; Yu, Hong-Jeng

doi:10.1016/j.jdiacomp.2016.01.002

Cited by 11 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diabetic bladder dysfunction found detrusor contractility altered with parasympathetic impairment [ 33 ]. Diabetic neuropathy with autonomic impairment causes lower urinary tract symptoms, rather than HbA1c being a predictor in females with DM [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Females with Diabetes Mellitus Increased the Incidence of Premenstrual Syndrome

Huang

Chien

Cheng

et al. 2022

Life

View full text Add to dashboard Cite

Background: Premenstrual syndrome (PMS) is a multifactorial disorder caused by hormone and autonomic imbalance. In our study, hyperglycemia-induced insulin secretion increased progesterone secretion and progressive autonomic imbalance. The young patients with diabetes mellitus (DM) revealed hypo-parasympathetic function and hypersympathetic function compared with nondiabetic controls. Young female patients with DM with higher blood sugar and autonomic malfunction may be associated with PMS. However, there is a lack of evidence about DM in females related to PMS. We evaluated female patients with DM who subsequently followed PMS in a retrospective cohort study. Methods: We retrieved data from the National Health Insurance Research Database in Taiwan. Female patients with DM between 20 and 50 years old were assessed by the International Classification of Disease, 9 Revision, Clinical Modification (ICD-9-CM) disease code of 250. Patients who were DM-free females were fourfold matched to the control group by age and disease index date. The ICD-9-CM disease code of 625.4 identified the incidence of PMS followed by the index date as events. The possible risk factors associated with PMS were detected with a Cox proportional regression. Results: DM was a significant risk factor for PMS incidence with an adjusted hazard ratio of 1.683 (95% confidence interval: 1.104–2.124, p < 0.001) in females after adjusting for age, other comorbidities, season, urbanization status of patients and the hospital status of visiting. Conclusion: This study noted an association between DM and PMS in female patients. Healthcare providers and female patients with DM must be aware of possible complications of PMS, aggressive glycemic control, decreased hyperglycemia and autonomic dysfunction to prevent this bothersome disorder.

show abstract

Section: Discussionmentioning

confidence: 99%

Females with Diabetes Mellitus Increased the Incidence of Premenstrual Syndrome

Huang

Chien

Cheng

et al. 2022

Life

View full text Add to dashboard Cite

show abstract

“…In women, diabetic neuropathy was significantly associated with LUTS. 97 In men, prostatic growth is stimulated by elevated activity of the sympathetic nerve, which is caused by elevated insulin levels. 98 Studies did not always collect data on comorbidities such as cardiovascular disease or T2D.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome is associated with prostate enlargement: a systematic review, meta-analysis, and meta-regression on patients with lower urinary tract symptom factors

Omran

Leca

Oštarijaš

et al. 2021

Therapeutic Advances in Endocrinology

View full text Add to dashboard Cite

Background: Metabolic syndrome (MetS) is defined by at least three of the following five criteria: blood pressure ⩾130/85 mmHg, fasting blood glucose ⩾5.6 mmol/l, triglycerides concentration ⩾1.7 mmol/l, waist circumference ⩾102 cm (for men), and high-density lipoprotein cholesterol concentration <1.03 mmol/l (for men). MetS has been associated with worse lower urinary tract symptoms (LUTS) and higher International Prostate Symptom questionnaire scores. Materials and Methods: MEDLINE, Cochrane, ClinicalTrials.gov, and SCOPUS were critically appraised for all peer-reviewed manuscripts that suitably fulfilled our protocol’s inclusion criteria established a priori. Meta-analytical and meta-regression calculations were performed in R using the Sidik–Jonkman and Hartung–Knapp random effects model and predefined covariates. Results: A total of 70 studies ( n = 90,206) were included in qualitative synthesis. From these, 60 studies focused on MetS and LUTS: 44 reported positive correlations, 5 reported negative correlations, 11 reported no association, and 10 studies focused on MetS and total prostate volume (TPV). MetS positively correlated with moderate LUTS [odds ratio (OR) = 1.56, 95% confidence interval (CI) = 1.35–1.80], severe LUTS (OR = 2.35, 95% CI = 1.82–3.03), overactive bladder (OAB; OR = 3.2, 95% CI = 1.6–5.8), and nocturia severity (OR = 2.509, 95% CI = 1.571–4.007) at multivariate analysis. A total of 30 studies ( n = 22,206) were included in meta-analysis; MetS was significantly associated with higher TPV (mean differences = 4.4450 ml, 95% CI = 2.0177–6.8723), but no significant predictive factors for effect sizes were discovered. Conclusion: Our meta-analysis demonstrates a significant association between the aggravating effects of MetS, which commonly coexists with obesity and benign prostate enlargement.

show abstract

“…We did not find biomarkers most commonly associated with DM, including HgbA1c, fasting glucose, and fasting insulin, to be predictive of LUTS in the DM population, as has been suggested in other cross-sectional studies. 10,25 However, HgbA1c levels were predictive of LUTS in the general population—a population that presumably has not been influenced by medical management of serum glucose. It is unclear what this means clinically, as simply asking our patients with DM-related LUTS to improve their DM control may not immediately improve LUTS.…”

Section: Discussionmentioning

confidence: 99%