Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children’s Study (JECS)

Abstract

Background Placenta previa and placenta accreta associate with high morbidity and mortality for both mothers and fetus. Metal exposure may have relationships with placenta previa and placenta accreta. This study analyzed the associations between maternal metal (cadmium [Cd], lead [Pb], mercury [Hg], selenium [Se], and manganese [Mn]) concentrations and placenta previa and placenta accreta. Methods We recruited 17,414 women with singleton pregnancies. Data from a self-administered questionnaire regarding the first trimester and medical records after delivery were analyzed. Maternal blood samples were collected to measure metal concentrations. The subjects were classified into four quartiles (Q1, Q2, Q3, and Q4) according to metal concentrations. Results The odds ratio for placenta previa was significantly higher among subjects with Q4 Cd than those with Q1 Cd. The odds ratio for placenta previa was significantly higher for subjects with Q2 Pb than those with Q1 Pb. Conclusion Participants with placenta previa had higher Cd concentrations. However, this study was cross-sectional and lacked important information related to Cd concentration, such as detailed smoking habits and sources of Cd intake. In addition, the subjects in this study comprised ordinary pregnant Japanese women, and it was impossible to observe the relationship between a wide range of Cd exposure and placenta previa. Therefore, epidemiological and experimental studies are warranted to verify the relationship between Cd exposure and pregnancy abnormalities. Electronic supplementary material The online version of this article (10.1186/s12199-019-0795-7) contains supplementary material, which is available to authorized users.

Ameliorating potency of Chenopodium album Linn. and vitamin C against mercuric chloride-induced oxidative stress in testes of Sprague Dawley rats

“…In previous literature, variable effects of Mercury on animal growth have been reported [7]. Our results are in agreement with the reports of Mehboob and coworkers, who reported a decrease in body weight in Mercury-intoxicated group [7, 39]. In the current investigation, we observed that C. album and vitamin C ameliorated mercury-induced weight loss.…”

“…Approximately 2200 metric tons of mercury have been assessed to be released into the atmosphere annually [4]. Elevated levels of mercury can impair the brain, nerves, kidneys, muscles of adults, and the developing fetus [5–7]. Bronchitis, asthma, and temporary respiratory problems have been occurred due to inhalation or exposure to mercury vapors [8].…”

Effect of previous placenta previa on outcome of next pregnancy: a 10-year retrospective cohort study

“…Anderson-Bagga et al reported that prior placenta previa was a risk factor for placenta previa during subsequent pregnancies [15]. Placenta accreta and placenta previa have some common risk factors, such as disruption of the uterine endometrium, manual removal of the placenta, and uterine scarring due to intrauterine or intraoperative procedures or other gynecological surgeries [20]. Jauniaux et al reported that the complication of placenta previa was present in more than 90% of patients with placenta accreta [12,21].…”

“…The area of scarring will exhibit poor vascularization, deficient tissue oxygenation, and inflammation, which may inhibit reepithelialization and decidualization, leading to abnormal placental anchoring villi and invasion of trophoblasts [23]. Inappropriate implantation and placental development have been found during the subsequent pregnancy in women with a history of placenta previa [20]. In our study, the risk of PPH in women with a history of placenta previa was 2.25 times that in women without this history in the cesarean delivery group, but in the vaginal delivery group, a history of placenta previa did not increase the risk of PPH.…”

Elimination of marginal and partial placenta previa from clinical perspective: is it rational?

“…previa placenta, category, ultrasound, maternal outcome, perinatal outcome preterm delivery, or may have low birth weight or congenital defects [5].…”