Associations between occupational inhalation risks and FeNO levels in airway obstruction patients: results from the National Health and Nutrition Examination Survey, 2007&amp;ndash;2012

Huang, Yen-Hsiang; Yang, Mei‐Chen

doi:10.2147/copd.s146168

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…Only two studies were specifically dedicated to occupational obstructive pulmonary disease (See Supplementary Table 3, Additional File 3 ). A large, population study [ 37 ] and one from a nanoparticles research team [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

The value of fractional exhaled nitric oxide in occupational diseases – a systematic review

Oțelea

Fell

Handra

et al. 2022

J Occup Med Toxicol

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Fractional exhaled nitric oxide (FeNO) is a non-invasive biomarker of respiratory tract inflammation, originally designated to identify eosinophilic airway inflammation and to predict steroid response. The main field of application of this biomarker is asthma, but FeNO has also been used for other allergic and non-allergic pulmonary disorders such as chronic obstructive pulmonary disease, hypersensitivity pneumonitis and interstitial lung disease. A substantial part of respiratory diseases are related to work, and FeNO, a safe and easy measure to conduct, is a potential valid examination in an occupational setting.This systematic review assesses the value of measuring FeNO related to three types of airborne exposures: allergens, irritants, and respiratory particles inhaled during occupational activities. The review covers results from longitudinal and observational clinical studies, and highlights the added value of this biomarker in monitoring effects of exposure and in the diagnostic criteria of occupational diseases. This review also covers the possible significance of FeNO as an indicator of the efficacy of interventions to prevent work-related respiratory diseases.Initially, 246 articles were identified in PUBMED and SCOPUS. Duplicates and articles which covered results from the general population, symptoms (not disease) related to work, non-occupational diseases, and case reports were excluded. Finally, 39 articles contributed to this review, which led to the following conclusions:a) For occupational asthma there is no consensus on the significant value of FeNO for diagnosis, or on the magnitude of change needed after specific inhalation test or occupational exposure at the workplace. There is some consensus for the optimal time to measure FeNO after exposure, mainly after 24 h, and FeNO proved to be more sensitive than spirometry in measuring the result of an intervention. b) For other occupational obstructive respiratory diseases, current data suggests performing the measurement after the work shift. c) For interstitial lung disease, the evaluation of the alveolar component of NO is probably the most suitable.

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Section: Resultsmentioning

confidence: 99%

The value of fractional exhaled nitric oxide in occupational diseases – a systematic review

Oțelea

Fell

Handra

et al. 2022

J Occup Med Toxicol

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show abstract

“…Sólo dos estudios se dedicaron específicamente a la enfermedad pulmonar obstructiva ocupacional (véase la Tabla Suplementaria 3, Archivo Adicional 3): un gran estudio poblacional [37] y otro de un equipo de investigación sobre nanopartículas [38].…”

Section: Resultsunclassified

Utilidad de la fracción exhalada de óxido nítrico en las enfermedades profesionales: una revisión sistemática

et al. 2022

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La fracción exhalada de óxido nítrico (FeNO) es un biomarcador no-invasivo de la inflamación de las vías respiratorias, concebido originalmente para identificar la inflamación eosinofílica de las vías respiratorias y para predecir la respuesta a los esteroides. El principal campo de aplicación de este biomarcador es el asma, pero la FeNO también se ha utilizado para otros trastornos pulmonares alérgicos y no-alérgicos, como la enfermedad pulmonar obstructiva crónica, la neumonitis por hipersensibilidad y la enfermedad pulmonar intersticial. Una parte importante de las enfermedades respiratorias se relacionan con el trabajo, y la FeNO, una medida segura y fácil de realizar, es un examen potencialmente valioso en el entorno laboral. Esta revisión sistemática evalúa la utilidad de la medición de la FeNO en relación con tres tipos de exposición aérea: alérgenos, irritantes y partículas respiratorias inhaladas durante las actividades laborales. La revisión abarca los resultados de estudios clínicos longitudinales y observacionales, y destaca el valor añadido de este biomarcador en el seguimiento de los efectos de la exposición y en los criterios de diagnóstico de las enfermedades profesionales. Esta revisión también abarca la posible importancia de la FeNO como indicador de la eficacia de las intervenciones para prevenir enfermedades respiratorias relacionadas con el trabajo. Inicialmente se identificaron 246 artículos en PUBMED y SCOPUS. Se excluyeron duplicados y artículos que presentaban resultados de la población general, síntomas (no enfermedad) relacionados con el trabajo, enfermedades no-ocupacionales e informes de casos. Finalmente, se eligieron 39 artículos para esta revisión, lo que llevó a las siguientes conclusiones: a) Para el asma ocupacional no hay consenso sobre la utilidad significativa de la FeNO para el diagnóstico, ni sobre la magnitud del cambio necesario tras una prueba de inhalación específica o la exposición ocupacional en el lugar de trabajo. Existe cierto consenso sobre el momento óptimo para medir la FeNO después de la exposición, principalmente después de 24 h, y la FeNO resultó más sensible que la espirometría para medir el resultado de una intervención. b) Para otras enfermedades respiratorias obstructivas ocupacionales, los datos sugieren realizar la medición después de la jornada laboral. c) Para la enfermedad pulmonar intersticial, la evaluación del componente alveolar del NO podría ser la más adecuada.

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“…There are few studies dedicated to a specific occupational exposure potentially generating COPD [ 80 ]. Some of them assessed the acute effect of potential COPD agents by measuring FeNO and other markers of inflammation before and after a work shift.…”

Section: Ocopd: Diagnostic Challengesmentioning

confidence: 99%

Challenges in Diagnosing Occupational Chronic Obstructive Pulmonary Disease

et al. 2021

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Occupational chronic obstructive pulmonary disease (oCOPD) represents 15–20% of the global burden of this disease. Even if industrial bronchitis has long been known, new occupational hazards continue to emerge and enlarge the number of people exposed to risk. This review discusses the challenges related to the early detection of oCOPD, in the context of new exposures and of limited usage of methods for an efficient disease occupational screening. It underlines that a better translation into clinical practice of the new methods for lung function impairment measurements, imaging techniques, or the use of serum or exhaled breath inflammation biomarkers could add significant value in the early detection of oCOPD. Such an approach would increase the chance to stop exposure at an earlier moment and to prevent or at least slow down the further deterioration of the lung function as a result of exposure to occupational (inhaled) hazards.

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Associations between occupational inhalation risks and FeNO levels in airway obstruction patients: results from the National Health and Nutrition Examination Survey, 2007–2012

Cited by 4 publications

References 26 publications

The value of fractional exhaled nitric oxide in occupational diseases – a systematic review

The value of fractional exhaled nitric oxide in occupational diseases – a systematic review

Utilidad de la fracción exhalada de óxido nítrico en las enfermedades profesionales: una revisión sistemática

Challenges in Diagnosing Occupational Chronic Obstructive Pulmonary Disease

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