Associations between organophosphate esters and sex hormones among 6–19-year old children and adolescents in NHANES 2013–2014

Luo, Kai; Liu, Jihong; Wang, Yuqing; Aimuzi, Ruxianguli; Luo, Fei; Ao, Junjie; Zhang, Jun

doi:10.1016/j.envint.2020.105461

Cited by 81 publications

(24 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A population-based study published earlier this year reported that exposure to OPEs is associated with decreased levels of sex hormones (TT and E2) in adolescents and pubertal individuals, and it was indicated that this phenomenon was sex-dependent (a stronger inverse association with TT was observed in males and a stronger association with E2 in females). 31 This observation, however, was not entirely in line with our study. None of the metabolites in this previous study showed a significant association with TT in male adolescents.…”

Section: Discussioncontrasting

confidence: 61%

Association of urinary organophosphate esters level with sex steroid hormones levels in adult males: A nationwide study, NHANES 2013–2014

et al. 2022

View full text Add to dashboard Cite

Background: Exposure to environmental pollution via different mechanisms is associated with multiple endocrine dysfunctions. Organophosphate esters (OPEs) are endocrine-disrupting chemicals that affect sex steroid hormones. Purpose:We aimed to study the effect of OPEs and their metabolites, such as diphenyl phosphate (DPHP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), bis(2-chloroethyl) phosphate (BCEP), and dibutyl phosphate (DBUP), on sex steroid hormones in males. Design, setting, participants, and intervention: This cross-sectional analytical study analyzed data from the 2013-2014 National Health and Nutrition Examination Survey among 763 male participants aged ≥20 years. Main outcome measures:The relationships between the metabolites of OPEs and total testosterone, estradiol, sex hormone-binding globulin, and the ratio of total testosterone to estradiol (a parameter derived from total testosterone and estradiol) were evaluated using multivariate linear regression models that were adjusted for potential confounders.Results: A total of 763 participants, with a mean age of 44.59 (±15.59) years, were enrolled. Of these, 65.7% participants had non-Hispanic white ancestry, 9.83% had non-Hispanic black ancestry, and 15.97% had Hispanic ancestry. Participants with higher urinary level of DPHP had a lower level of total testosterone and estradiol. Moreover, higher urinary levels of BDCPP were associated with higher estradiol. Conclusion:According to our study, which is based on a representative population of US adults, exposure to OPEs was significantly associated with altered sex hormone levels (total testosterone and estradiol). Further studies focused on the underlying mechanisms regarding the association between each metabolite and sex steroid hormones are required.

show abstract

Section: Discussioncontrasting

confidence: 61%

Association of urinary organophosphate esters level with sex steroid hormones levels in adult males: A nationwide study, NHANES 2013–2014

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Potential confounding factors were considered according to previous researches (Juonala et al 2019 ; Luo et al 2020 ), including gender, age, ethnicity/race, ratio of family income to poverty (PIR), body mass index (BMI), tobacco products use, dietary vitamin D intakes, alcohol use, physical activity, kidney health, and NHANES cycle. Specifically, PIR represents the social economic status of the family (or individual), and is a ratio of family income to poverty guidelines specific to the survey year, family size, and geographic location.…”

Section: Methodsmentioning

confidence: 99%

The association between tobacco smoke exposure and vitamin D levels among US general population, 2001–2014: temporal variation and inequalities in population susceptibility

Yuan

2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

Tobacco smoking is endocrine-disrupting and may interfere with vitamin D endocrine systems (VDES), but supporting evidence is limited and inconsistent. Also, there is a lack of evidence on whether the association between tobacco smoke exposure and VD levels exhibit temporal variation. Data from the National Health and Nutrition Examination Survey was used to evaluate the association between tobacco smoke exposure and VD levels among US general participants from 2001 to 2014. We examined the linear association between serum cotinine and 25(OH)D concentrations, as well as relationship between tobacco smoke exposure categories (active, passive, non-smoking) with VD status (deficiency, inadequacy, sufficiency, intoxication), and assessed whether specific gender, age (3–11, 12–19, 20–59, ≥ 60 years), ethnicity/race, or body mass index (BMI) groups were disproportionately impacted. During 2001–2004, a decrease in both serum cotinine and passive smoking prevalence was observed, with a stabilized active smoking rate. The estimates for the association between tobacco smoke exposure and suboptimal VD levels increased over the study period. Overall results indicated that serum cotinine was negatively associated with 25(OH)D in all participants. Tobacco smoke exposure, including both active and passive smoking exposure, was associated with increased risk of VD deficiency. Moreover, active smoking was additionally related to enhanced risk of VD inadequacy. These associations showed some age and gender differences, with consistent and stronger associations observed in female adults. In contrast, effects of tobacco smoke exposure on VD levels were mostly negative or non-significant among children and adolescents aged 3–19 years. The percentage of US general population with active smoking exposure stabilized over the 14-year period and was still high. Tobacco smoke exposure may disrupt vitamin D levels with an increasing temporal trend in the risk. Our results also provided initial evidence of smoking exposure on VD intoxication, which needs to be further verified. Convincing studies have linked tobacco use exposure, to dysfunctional VDES accompanied with declined serum levels of VD metabolites. However, evidence on the association between tobacco smoke exposure and VD status was rather limited and inconsistent, and there were no researches to date that estimated the temporal variation of the association as well as the effects of smoke exposure on VD intoxication. This study analyzed national survey data, to evaluate the temporal trends in effects of tobacco smoke exposure on VD levels over a decade, and to comprehensively assess the impacts of tobacco smoke exposure on VD levels across specific subgroups. The evidence suggests that the prevalence of active smoking exposure stabilized over the 14-year period and was still high. Moreover, tobacco smoke exposure may disrupt vitamin D levels among general population, with an increasing temporal trend and age-, gender-differences in risk. Supplementary Information...

show abstract

“…Considering the pubertal status may distort the associations between DII and sex hormones, pubertal condition was also included in our analysis. We defined puberty as TT ≥ 50 ng/dl for males according to previous studies (9,41,42). All detailed measurement processes of these variable were publicly available at www.cdc.gov/nchs/nhanes/.…”

Section: Covariatesmentioning

confidence: 99%

“…Previous studies have demonstrated that TT, SHBG and E2 not only play essential roles in reproduction, such as onset of puberty and the subsequent sexual maturation, including spermatogenesis and secondary sex characteristic formation and maintenance, etc., but also non-sexual biological process, including bone growth, body composition, and the metabolism of glucose, lipid and protein (4)(5)(6). A lack of sex steroid may lead to delay of puberty, reduced bone density and size, obesity, impaired insulin sensitivity, and increased risk of dyslipidemia, hypertension, metabolic syndrome and cardiovascular diseases (6)(7)(8)(9). Accumulative studies have suggested that sex hormones play a key role in the development and growth in children and adolescents and the disorder of sex hormones may result in a heavy disease burden (10).…”

Section: Introductionmentioning

confidence: 99%

“…, but also non-sexual biological process, including bone growth, body composition, and the metabolism of glucose, lipid and protein ( 4 – 6 ). A lack of sex steroid may lead to delay of puberty, reduced bone density and size, obesity, impaired insulin sensitivity, and increased risk of dyslipidemia, hypertension, metabolic syndrome and cardiovascular diseases ( 6 – 9 ). Accumulative studies have suggested that sex hormones play a key role in the development and growth in children and adolescents and the disorder of sex hormones may result in a heavy disease burden ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Association Between Dietary Inflammatory Potential and Sex Hormones in Male Children and Adolescents Aged 6–19 Years

et al. 2021

View full text Add to dashboard Cite

AimsThis study aimed to assess the relationship between dietary inflammatory index (DII) and sex hormones in male children and adolescents aged 6-19 years.MethodsWe obtained data from the 2013-2016 National Health and Nutrition Examination Survey (NHANES). Male participants aged 6-19 years old with the complete data of DII and sex hormones were included. Weighted multiple regression analysis and subgroup analysis were preformed to estimate the independent relationship between DII and sex hormones.ResultsA total of 1717 male participants with the average age of 13.02 ± 3.82 years were enrolled, of whom 41.3% (n=713) were children and 58.47% (n=1004) were adolescents. In children, mean DII was 0.18 ± 1.67, with scores ranging from -4.53 to 4.08. As for adolescents, the mean DII was 0.36 ± 1.98, mean total testosterone (TT) was 376.94 ± 206.69 ng/dl overall. A negative association between DII with TT and estradiol (E2) was observed (TT: β=-11.97, P=0.0006; E2: β=-0.45, P=0.0108) in male adolescent. Subgroup analysis and interaction test results indicated that this association was similar in male adolescents with different body mass index. No statistically significant association was observed in children.ConclusionsPro-inflammatory diet was associated with lower TT and E2 level in male adolescent, while no association with statistical significance between them was observed in male children. However, more studies are still needed to validate the causal relationship between DII and sex hormones.

show abstract

Associations between organophosphate esters and sex hormones among 6–19-year old children and adolescents in NHANES 2013–2014

Cited by 81 publications

References 49 publications

Association of urinary organophosphate esters level with sex steroid hormones levels in adult males: A nationwide study, NHANES 2013–2014

Association of urinary organophosphate esters level with sex steroid hormones levels in adult males: A nationwide study, NHANES 2013–2014

The association between tobacco smoke exposure and vitamin D levels among US general population, 2001–2014: temporal variation and inequalities in population susceptibility

The Association Between Dietary Inflammatory Potential and Sex Hormones in Male Children and Adolescents Aged 6–19 Years

Contact Info

Product

Resources

About