Associations between personal exposure to air pollutants and lung function tests and cardiovascular indices among children with asthma living near an industrial complex and petroleum refineries

Smargiassi, Audrey; Goldberg, Mark S.; Wheeler, Amanda; Plante, Céline; Valois, Marie‐France; Mallach, Gary; Kauri, Lisa Marie; Shutt, Robin; Bartlett, Susan J.; Raphoz, Marie; Liu, Ling

doi:10.1016/j.envres.2014.03.030

Cited by 82 publications

(45 citation statements)

References 35 publications

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“…Most previous longitudinal studies of air pollution effects on asthma have relied solely on central monitoring stations to estimate the exposure of an entire community. A small number of studies have utilized personal air pollution sensors, but due to the bulky nature of the monitoring equipment, the follow‐up duration has necessarily been limited. We have for the first time demonstrated the feasibility of long‐term personal air pollution exposure monitoring.…”

Section: Discussionmentioning

confidence: 99%

Effects of personal air pollution exposure on asthma symptoms, lung function and airway inflammation

Chambers

Finch

Edwards

et al. 2018

Clin Experimental Allergy

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Section: Discussionmentioning

confidence: 99%

Effects of personal air pollution exposure on asthma symptoms, lung function and airway inflammation

Chambers

Finch

Edwards

et al. 2018

Clin Experimental Allergy

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“…Children with physician-diagnosed cases of asthma were identified from records at a paediatric asthma clinic in a tertiary-care adult Montreal hospital (Maisonneuve-Rosemont), the main centre for referrals for childhood asthma in the area (details described previously [34]). To meet sample size requirements, additional children were recruited in the latter half of the study from local schools.…”

Section: Methodsmentioning

confidence: 99%

“…This finding was the motivation for the present study that was designed as a panel study among asthmatic children who lived near these petroleum refinery facilities. The objective was to determine whether acute, personal exposures to selected air pollutants were associated with selected health endpoints [32–34]. In a previous paper, we measured daily variations in personal exposure to fine particulates and estimated oxidative burden from samples of PM 2.5 [35].…”

Section: Introductionmentioning

confidence: 99%

Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children

et al. 2016

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BackgroundChildren with asthma experience increased susceptibility to airborne pollutants. Exposure to traffic and industrial activity have been positively associated with exacerbation of symptoms as well as emergency room visits and hospitalisations. The effect of trace metals contained in fine particulate matter (aerodynamic diameter 2.5 μm and lower, PM2.5) on acute health effects amongst asthmatic children has not been well investigated. The objective of this panel study in asthmatic children was to determine the association between personal daily exposure to ambient trace metals and airway inflammation, as measured by fractional exhaled nitric oxide (FeNO).MethodsDaily concentrations of trace metals contained on PM2.5 were determined from personal samples (n = 217) collected from 70 asthmatic school aged children in Montreal, Canada, over ten consecutive days. FeNO was measured daily using standard techniques.ResultsA positive association was found between FeNO and children’s exposure to an indicator of vehicular non-tailpipe emissions (8.9 % increase for an increase in the interquartile range (IQR) in barium, 95 % confidence interval (CI): 2.8, 15.4) as well as exposure to an indicator of industrial emissions (7.6 % increase per IQR increase in vanadium, 95 % CI: 0.1, 15.8). Elevated FeNO was also suggested for other metals on the day after the exposure: 10.3 % increase per IQR increase in aluminium (95 % CI: 4.2, 16.6) and 7.5 % increase per IQR increase in iron (95 % CI: 1.5, 13.9) at a 1-day lag period.ConclusionsExposures to ambient PM2.5 containing trace metals that are markers of traffic and industrial-derived emissions were associated in asthmatic children with an enhanced FeNO response.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-016-0173-5) contains supplementary material, which is available to authorized users.

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“…Because B[a]P is ubiquitous in the environment and in many diets (Howsam and Jones, 1998), human contact is unavoidable. Adverse effects of B[a]P include carcinogenicity, mutagenicity, cardiovascular disease, impaired lung function, neurological effects in children and adults, decreased oxygen saturation levels, artery thickness and blood pressure (Perera et al , 1999; Perera et al , 2006; Gunes et al , 2007; Tang et al , 2007; Geerts et al , 2008; McCallister et al , 2008; D Jung, 2009; Edwards et al , 2010; Incardona et al , 2011; Genies, 2013; Jung et al , 2014; Smargiassi et al , 2014; Gerger et al , 2015; Huang et al , 2015). B[a]P has been detected in human placenta, umbilical cord blood, maternal blood and breast milk samples worldwide (Madhavan and Naidu, 1995; Perera et al , 1998; Perera et al , 2006) and B[a]P exposures produce developmental and reproductive toxicity, and behavior effects in multiple generation animal studies (Tracey et al , 2013; Corrales et al , 2014b; Vignet et al , 2015).…”

Section: Introductionmentioning

confidence: 99%

Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish

Knecht

Truong

Marvel

et al. 2017

Toxicology and Applied Pharmacology

118

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Benzo[a]pyrene (B[a]P) is a well-known genotoxic polycylic aromatic compound whose toxicity is dependent on signaling via the aryl hydrocarbon receptor (AHR). It is unclear to what extent detrimental effects of B[a]P exposures might impact future generations and whether transgenerational effects might be AHR-dependent. This study examined the effects of developmental B[a]P exposure on 3 generations of zebrafish. Zebrafish embryos were exposed from 6 – 120 hours post fertilization (hpf) to 5 and 10 μM B[a]P and raised in chemical- free water until adulthood (F0). Two generations were raised from F0 fish to evaluate transgenerational inheritance. Morphological, physiological and neurobehavioral parameters were measured at two life stages. Juveniles of the F0 and F2 exhibited hyper locomotor activity, decreased heartbeat and mitochondrial function. B[a]P exposure during development resulted in decreased global DNA methylation levels and generally reduced expression of DNA methyltransferases in wild type zebrafish, with the latter effect largely reversed in an AHR2-null background. Adults from the F0 B[a]P exposed lineage displayed social anxiety-like behavior. Adults in the F2 transgeneration manifested gender-specific increased body mass index (BMI), increased oxygen consumption and hyper-avoidance behavior. Exposure to benzo[a]pyrene during development resulted in transgenerational inheritance of neurobehavioral and physiological deficiencies. Indirect evidence suggested the potential for an AHR2-dependent epigenetic route.

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Associations between personal exposure to air pollutants and lung function tests and cardiovascular indices among children with asthma living near an industrial complex and petroleum refineries

Cited by 82 publications

References 35 publications

Effects of personal air pollution exposure on asthma symptoms, lung function and airway inflammation

Effects of personal air pollution exposure on asthma symptoms, lung function and airway inflammation

Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children

Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish

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