Associations between prenatal exposure to air pollution, small for gestational age, and term low birthweight in a state-wide birth cohort

Vinikoor-Imler, Lisa; Davis, Jerry; Meyer, Robert E.; Messer, Lynne C.; Luben, Thomas J.

doi:10.1016/j.envres.2014.03.040

Cited by 71 publications

(48 citation statements)

References 38 publications

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“…Although some of these significant associations might be pure chance findings, this is not likely to explain the consistent and significant associations observed across the four different metrics used to assess fetal growth. Our results are in line with some recent studies also reporting a decreased risk of low birth weight at term or higher birth weights associated with prenatal exposure to NO 2 (Laurent et al, 2013;Kashima et al, 2011;Hannam et al, 2014) or other air pollutants (Vinikoor-Imler et al, 2014;Laurent et al, 2013;Sellier et al, 2014;Madsen et al, 2010). In a recent meta-analysis on this topic, Stieb et al observed a high degree of heterogeneity among studies as measured by the I² value (Stieb et al, 2012).…”

Section: Discussionsupporting

confidence: 95%

“…Urban-rural status may also influence the relation between air pollution and fetal growth because it may increase exposure contrasts and pollutant mixtures but also because characteristics of populations may vary substantially from urban to rural settings; these differences, which may include health behaviors as well as time spent both outdoors and commuting, may increase confounding or mediating biases (Malmqvist et al, 2011). However, to our knowledge, only one previous study has explored the influence of air pollution on fetal growth according to urban-rural status (Vinikoor-Imler et al, 2014).…”

Section: Introductionmentioning

confidence: 84%

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Sex-specific differences in fetal growth in newborns exposed prenatally to traffic-related air pollution in the PELAGIE mother–child cohort (Brittany, France)

Bertin¹,

Serrano²,

Monfort³

et al. 2015

Environmental Research

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Section: Discussionsupporting

confidence: 95%

Section: Introductionmentioning

confidence: 84%

Sex-specific differences in fetal growth in newborns exposed prenatally to traffic-related air pollution in the PELAGIE mother–child cohort (Brittany, France)

Bertin¹,

Serrano²,

Monfort³

et al. 2015

Environmental Research

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“…Combined with ground-level monitoring, the “space-time fusion” model increased spatial and temporal resolution of air quality compared to using monitors alone, and thus allowed us to study a geographically dispersed population. The HBM has recently been successfully used to study associations with birth defects and low birth weight outcomes [8, 9]. We utilized the model to conduct a retrospective analysis of whether or not air pollution influences cognitive performance among participants of the national Alzheimer's Disease Center (ADC) program.…”

Section: Introductionmentioning

confidence: 99%

Association of Low-Level Ozone with Cognitive Decline in Older Adults

Cleary

Cifuentes

Grinstein

et al. 2017

JAD

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Increasing evidence points to an association of airborne pollutant exposure with respiratory, cardiovascular, and neurological pathology. We examined whether or not ground-level ozone or fine particulate matter ≤ 2.5 μm in diameter (PM2.5) was associated with accelerated cognitive decline. Using repeated measures mixed regression modeling, we analyzed cognitive performance of a geographically diverse sampling of individuals from the National Alzheimer's Coordinating Center between 2004–2008. Ambient air concentrations of ozone and PM2.5 were established using a space-time Hierarchical Bayesian Model that statistically merged air monitor data and modeled air quality estimates. We then compared the ambient regional concentrations of ozone and PM2.5 with the rate of cognitive decline in residents within those regions. Increased levels of ozone correlated with an increased rate of cognitive decline, following adjustment for key individual and community-level risk factors. Furthermore, individuals harboring one or more APOE4 alleles exhibited a faster rate of cognitive decline. The deleterious association of ozone was confined to individuals with normal cognition who eventually became cognitively impaired as opposed to those who entered the study with baseline impairment. In contrast to ozone, we did not observe any correlation between ambient PM2.5 and cognitive decline at regulatory limits set by the Environmental Protection Agency. Our findings suggest that prolonged exposure to ground-level ozone may accelerate cognitive decline during the initial stages of dementia development.

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“…Further, air pollution has been associated with other adverse birth outcomes such as low birth weight, small for gestational age, and birth defects (Ha et al,2014; Harris et al,2014; Hwang et al,2011; Vinikoor-Imler et al,2014). …”

Section: Introductionmentioning

confidence: 99%

Ambient air pollutant PM10 and risk of preterm birth in Lanzhou, China

Zhao

Qiu

Zhang³

et al. 2015

Environment International

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Importance Exposure to ambient particulate matter during pregnancy has been suggested as a risk factor for preterm birth. However results from limited epidemiologic studies have been inconclusive. Very few studies have been conducted in areas with high air pollution levels. Objective We investigated the hypothesis that high level exposure to particulate matter with aerodynamic diameter no larger than 10µm (PM10) during pregnancy increases the risk of preterm birth. Methods A birth cohort study was carried out between 2010–2012 in Lanzhou, China, including 8,969 singleton live births with available information on daily PM10 levels from four monitoring stations, individual exposures during pregnancy were calculated using inverse-distance weighting based on both home and work addresses. Unconditional logistic regression modeling was used to examine the associations between PM10 exposure and risk of preterm birth and its clinical subtypes. Results Increased risk of very preterm birth was associated with exposure to PM10 during the last two months of pregnancy (OR, 1.07; 95%CI, 1.02–1.13 per 10µg/m3 increase for last four weeks before delivery; 1.09; 1.02–1.15 for last six weeks before delivery; 1.10; 1.03–1.17 for last eight weeks before delivery). Compared to the U.S. National Ambient Air Quality Standard (150µg/m3), higher exposure level (≥150µg/m3) of PM10 during entire pregnancy was associated with an increased risk of preterm birth (1.48; 1.22–1.81) and the association was higher for medically indicated preterm birth (1.80, 1.24–2.62) during entire pregnancy and for very preterm during last 6 weeks before delivery (2.03, 1.11–3.72). Conclusions and relevance Our study supports the hypothesis that exposure to high levels of ambient PM10 increases the risk of preterm birth. Our study also suggests that the risk may vary by clinical subtypes of preterm birth and exposure time windows. Our findings are relevant for health policy makers from China and other regions with high levels of air pollution to facilitate the efforts of reducing air pollution level in order to protect public health.

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Associations between prenatal exposure to air pollution, small for gestational age, and term low birthweight in a state-wide birth cohort

Cited by 71 publications

References 38 publications

Sex-specific differences in fetal growth in newborns exposed prenatally to traffic-related air pollution in the PELAGIE mother–child cohort (Brittany, France)

Sex-specific differences in fetal growth in newborns exposed prenatally to traffic-related air pollution in the PELAGIE mother–child cohort (Brittany, France)

Association of Low-Level Ozone with Cognitive Decline in Older Adults

Ambient air pollutant PM10 and risk of preterm birth in Lanzhou, China

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