Purpose:The aim of the study is to identify the relationships between quality of life and physical activity levels in urban adults from single-person households. Design/Methodology/Approach: The cross-sectional study involved 1828 single respondents, 1000 women and 828 men, from Wrocław, Poland. The diagnostic tools included the World Health Organization Quality of Life-BREF and International Physical Activity Questionnaire -Short Version. Respondents' physical activity was assessed following WHO recommendations. The main statistical method was logistic regression analysis. Findings: Most respondents assessed their overall quality of life, perceived health condition and quality of life in the physical, psychological, social, and environmental domains as average or above average. The majority of single female (73.2%) and male (77.3%) respondents also met the WHO physical activity recommendations. The level of physical activity had a statistically significant impact on men's overall quality of life, women's perceived health condition, and men's quality of life in the psychological and environmental domains. Practical Implications: The study results suggest that the assessment of quality of life and physical activity in people of different marital status should be continued. This will make it possible to take effective preventive and therapeutic measures in relation to groups at the highest risk of hypokinesia, which can also be important for their quality of life. Originality/value: The results of the conducted research make it possible to diagnose and forecast human behaviors, especially those related to psychophysical activity.